Anzeige
Erschienen in:
2008 | OriginalPaper | Buchkapitel
Computational Pathology Analysis of Tissue Microarrays Predicts Survival of Renal Clear Cell Carcinoma Patients
verfasst von : Thomas J. Fuchs, Peter J. Wild, Holger Moch, Joachim M. Buhmann
Erschienen in: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008
Verlag: Springer Berlin Heidelberg
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
Renal cell carcinoma (RCC) can be diagnosed by histological tissue analysis where exact counts of cancerous cell nuclei are required. We propose a completely automated image analysis pipeline to predict the survival of RCC patients based on the analysis of immunohistochemical staining of MIB-1 on tissue microarrays. A random forest classifier detects cell nuclei of cancerous cells and predicts their staining. The classifier training is achieved by expert annotations of 2300 nuclei gathered from tissues of 9 different RCC patients. The application to a test set of 133 patients clearly demonstrates that our computational pathology analysis matches the prognostic performance of expert pathologists.