Concomitant Radiation, Mitomycin C And 5 Flourouracil Infusion in Gastrointestinal Cancer - A Preliminary Report

For a decade, concomitant radiation and chemotherapy with 5-Fluoro- uracil and Mitomycin C has been used in treating carcinoma of anal canal with favourable results (Nigro1, Cummings2, Byfield3). Similar encouraging results have been reported with esophageal carcinoma (Byfield4, Franklin5, Keane6). To date, this combination therapy has been used chiefly in squamous cell carcinoma. It’s efficacy in adenocarcinoma is not well documented, though felt to be ineffective by some authors. Wassif7 has employed similar combination in patients with advanced stages of rectal carcinoma, and reported local response rate of 79–85%.