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Journal of Nanoparticle Research

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01.10.2012 | Research Paper

Development of a gold-nanostructured surface for amperometric genosensors

Erschienen in: Journal of Nanoparticle Research | Ausgabe 10/2012

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Abstract

A gold-nanostructured surface has been obtained by stable deposition of chemically synthesized gold nanoparticles (2.1–5.5 nm size range) on a gold substrate through a dithiol linker. The method proposed for the obtainment of the nanostructure is suitable for the further stable anchoring of a peptide nucleic acid oligomer through four amine groups of lysine terminal residues, leading to fairly reproducible systems. The geometric area of the nanostructured surface is compared with those of a smooth and of an electrochemically generated nanostructured surface by depositing a probe bearing an electrochemically active ferrocene residue. Despite the area of the two nanostructures being quite similar, the response toward a 2 nM target oligonucleotide sequence is particularly high when using the surface built up by nanoparticle deposition. This aspect indicates that morphologic details of the nanostructure play a key role in conditioning the performances of the genosensors.

Vorheriger Artikel Fluorescence quantum efficiency of CdSe/ZnS quantum dots functionalized with amine or carboxyl groups

Nächster Artikel Iron-based bimagnetic core/shell nanostructures in SiO2: a TEM, MEIS, and energy-resolved XPS analysis

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Titel: Development of a gold-nanostructured surface for amperometric genosensors
Publikationsdatum: 01.10.2012
Erschienen in: Journal of Nanoparticle Research / Ausgabe 10/2012
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-012-1148-2

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