Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Erschienen in:
RVE Procedure for Estimating the Elastic Properties of Inhomogeneous Microstructures Such as Bone Tissue Kapitel lesen Erstes Kapitel lesen

2015 | OriginalPaper | Buchkapitel

Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts: A Finite Element Investigation

verfasst von : Martin Weidling, Silke Besdo, Tobias Schilling, Michael Bauer, Thomas Hassel, Friedrich-Wilhelm Bach, Hans Jürgen Maier, Jacques Lamon, Axel Haverich, Peter Wriggers

Erschienen in: Biomedical Technology

Verlag: Springer International Publishing

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these grafts and gradually lose their function as the graft develops its strength are a possible solution. We are developing magnesium alloy scaffolds for this purpose. The finite element method was used to perform simulations wherein scaffolds are deformed according to the heart movement. This allows us to identify highly stressed regions within the implant that need design changes. Preformed scaffolds were determined to have significantly lower stresses in comparison to flat ones. The method of tensile triangles suggests shape changes for notable stress reduction. Furthermore, new scaffold shapes were developed and simulated. Two of them are recommended for further examinations through in vitro and in vivo tests. A completely new alternative scaffold concept is also proposed.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Jetzt informieren
Vorheriges Kapitel On the Role of Phase Change in Modelling Drug-Eluting Stents
Nächstes Kapitel Finite Element Analysis of Transcatheter Aortic Valve Implantation in the Presence of Aortic Leaflet Calcifications
Fußnoten
1
Computer Aided Engineering.
 
2
Computer Aided Design.
 
Literatur
1.
Athanasuleas, C.L., Stanley, A.W., Buckberg, G.D., et al.: Surgical anterior ventricular endocardial restoration (SAVER) in the dilated remodeled ventricle after anterior myocardial infarction. RESTORE group. Reconstructive Endoventricular Surgery, returning Torsion Original Radius Elliptical Shape to the LV. J. Am. Coll. Cardiol. 37(5), 1199–1209 (2001)CrossRef
2.
Cooley, D.A.: Ventricular endoaneurysmorrhaphy: results of an improved method of repair. Tex. Heart Inst. J. 16(2), 72–75 (1989)MathSciNet
3.
Dor, V.: Surgery for left ventricular aneurysm. Curr. Opin. Cardiol. 5(6), 773–780 (1990)CrossRef
4.
Adhyapak, S.M., Parachuri, V.R.: Architecture of the left ventricle: insights for optimal surgical ventricular restoration. Heart Fail. Rev. 15(1), 73–83 (2010)CrossRef
5.
Anderson, R.H., Ho, S.Y., Redmann, K., et al.: The anatomical arrangement of the myocardial cells making up the ventricular mass. Eur. J. Cardiothorac. Surg. 28(4), 517–525 (2005)CrossRef
6.
Williams, A.R., Hatzistergos, K.E., Addicott, B., et al.: Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. Circulation 127(2), 213–223 (2013)CrossRef
7.
Schilling, T., Cebotari, S., Tudorache, I., et al.: Tissue engineering of vascularized myocardial prosthetic tissue. Chirurg 82(4), 319–324 (2011). in GermanCrossRef
8.
Badylak, S.F.: The extracellular matrix as a scaffold for tissue reconstruction. Semin. Cell Dev. Biol. 13(5), 377–383 (2002)CrossRef
9.
Wei, H., Liang, H., Lee, M., et al.: Construction of varying porous structures in acellular bovine pericardia as a tissue-engineering extracellular matrix. Biomaterials 26(14), 1905–1913 (2005)CrossRef
10.
Taheri, S.A., Ashraf, H., Merhige, M., et al.: Myoangiogenesis after cell patch cardiomyoplasty and omentopexy in a patient with ischemic cardiomyopathy. Tex Heart Inst. J. 32(4), 598–601 (2005)
11.
Wang, B., Borazjani, A., Tahai, M., et al.: Fabrication of cardiac patch with decellularized porcine myocardial scaffold and bone marrow mononuclear cells. J. Biomed. Mater. Res. 94(4), 1100–1110 (2010)
12.
Tudorache, I., Kostin, S., Meyer, T., et al.: Viable vascularized autologous patch for transmural myocardial reconstruction. Eur. J. Cardiothorac. Surg. 36(2), 306–311 (2009)CrossRef
13.
Badylak, S.F., Kochupura, P.V., Cohen, I.S., et al.: The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium. Cell Transplant. 15(Suppl 1), 29–40 (2006)CrossRef
14.
Wiltfang, J., Merten, H.A., Schlegel, K.A., et al.: Degradation characteristics of \({\alpha }\) and \({\beta }\) tri-calcium-phosphate (TCP) in minipigs. J. Biomed. Mater. Res. 63(2), 115–121 (2002)CrossRef
15.
Nair, L.S., Laurencin, C.T.: Biodegradable polymers as biomaterials. Prog. Polym. Sci.32(8–9), 762–798 (2007)
16.
Pietrzak, W.S., Sarver, D., Verstynen, M.: Bioresorbable implants – practical considerations. Bone 19(1), 109–119 (1996)CrossRef
17.
van der Giessen, W.J., Lincoff, A.M., Schwartz, R.S., et al.: Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries. Circulation 94(7), 1690–1697 (1996)CrossRef
18.
Atrens, A., Song, G., Cao, F., et al.: Advances in Mg corrosion and research suggestions. J. Magnes. Alloy. 1(3), 177–200 (2013)
19.
Witte, F., Hort, N., Vogt, C., et al.: Degradable biomaterials based on magnesium corrosion. Curr. Opin. Solid State Mater. Sci. 12(5–6), 63–72 (2008)CrossRef
20.
Kirkland, N., Lespagnol, J., Birbilis, N., et al.: A survey of bio-corrosion rates of magnesium alloys. Corros. Sci. 52(2), 287–291 (2010)CrossRef
21.
Staiger, M.P., Pietak, A.M., Huadmai, J., et al.: Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials 27(9), 1728–1734 (2006)CrossRef
22.
Bach, F., Haverich, A., Cebotari. S., Biskup, C., Schuster, B.: Supporting element for tissue implants (Patent WO 2011/101142 A1)
23.
Walker, J., Shadanbaz, S., Woodfield, T.B.F., et al.: The in vitro and in vivo evaluation of the biocompatibility of Mg alloys. Biomed. Mater. 9(1), 15006 (2014)CrossRef
24.
Schilling, T., Brandes, G., Tudorache, I., et al.: In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model. BiomedizinischeTechnik/Biomedical Engineering 58(5), 407–416 (2013)
25.
Bauer, M., Schilling, T., Weidling, M., et al.: Geometric adaption of biodegradable magnesium alloy scaffolds to stabilise biological myocardial grafts, Part I. J. Mater. Sci. Mater. Med. 25(3), 909–916 (2014)CrossRef
26.
Bonora, P., Andrei, M., Eliezer, A., et al.: Corrosion behaviour of stressed magnesium alloys. Corros. Sci. 44(4), 729–749 (2002)CrossRef
27.
Hoffmeister, B.K., Handley, S.M., Wickline, S.A., et al.: Ultrasonic determination of the anisotropy of Young’s modulus of fixed tendon and fixed myocardium. J. Acoust. Soc. Am. 100(6), 3933–3940 (1996)CrossRef
28.
Weidling, M., Besdo, S., Schilling, T., et al.: Finite element simulation of myocardial stabilising structures and development of new designs. Biomedical Engineering/BiomedizinischeTechnik. 58 (Suppl. 1)(2013)
29.
Biskup, C., Hepke, M., Grittner, N., et al.:AWIJ cutting of structures made of magnesium alloys for the cardiovascular surgery. In: American WJTA Conference and Expo (2009)
30.
Mattheck, C.: Secret Design Rules of Nature. Überw. Ill, 1st edn. Forschungszentrum Karlsruhe, Karlsruhe (2007)
31.
Feng, B., Veress, A., Sitek, A., et al.: Estimation of mechanical properties from gated SPECT and cine MRI data using a finite-element mechanical model of the left ventricle. IEEE Trans. Nucl. Sci. 48(3), 725–733 (2001)CrossRef
32.
Feng, L., Weixue, L., Ling, X., et al.: The construction of three-dimensional composite finite element mechanical model of human left ventricle. JSME Int. J. Ser C 44(1), 125–133 (2001)CrossRef
33.
Wong, J., Kuhl, E.: Generating fibre orientation maps in human heart models using Poisson interpolation. Comput. Methods Biomech. Biomed. Eng.: 1–10 (2012)
34.
Watanabe, H., Sugiura, S., Kafuku, H., et al.: Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method. Biophys. J. 87(3), 2074–2085 (2004)CrossRef
35.
Song, G., Atrens, A.: Recent insights into the mechanism of magnesium corrosion and research suggestions. Adv. Eng. Mater. 9(3), 177–183 (2007)CrossRef
36.
Winzer, N., Atrens, A., Song, G., et al.: A critical review of the stress corrosion cracking (SCC) of Magnesium alloys. Adv. Eng. Mater. 7(8), 659–693 (2005)CrossRef
37.
Tokaji, K., Kamakura, M., Ishiizumi, Y., et al.: Fatigue behaviour and fracture mechanism of a rolled AZ31 Magnesium alloy. Int. J. Fatigue 26(11), 1217–1224 (2004)CrossRef
38.
Mayer, H., Papakyriacou, M., Zettl, B., et al.: Influence of porosity on the fatigue limit of die cast magnesium and aluminium alloys. Int. J. Fatigue 25(3), 245–256 (2003)CrossRef
Metadaten
Titel
Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts: A Finite Element Investigation
verfasst von
Martin Weidling
Silke Besdo
Tobias Schilling
Michael Bauer
Thomas Hassel
Friedrich-Wilhelm Bach
Hans Jürgen Maier
Jacques Lamon
Axel Haverich
Peter Wriggers
Copyright-Jahr
2015
Buch
Biomedical Technology

Print ISBN: 978-3-319-10980-0

Electronic ISBN: 978-3-319-10981-7

Copyright-Jahr: 2015

DOI
https://doi.org/10.1007/978-3-319-10981-7_6

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise