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Erschienen in:
2010 | OriginalPaper | Buchkapitel
Efficient Computation of Approximate Gene Clusters Based on Reference Occurrences
verfasst von : Katharina Jahn
Erschienen in: Comparative Genomics
Verlag: Springer Berlin Heidelberg
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Whole genome comparison based on the analysis of gene cluster conservation has become a popular approach in comparative genomics. While gene order and gene content as a whole randomize over time, it is observed that certain groups of genes which are often functionally related remain co-located across species. However, the conservation is usually not perfect which turns the identification of these structures, often referred to as approximate gene clusters, into a challenging task. In this paper, we present a polynomial time algorithm that computes approximate gene clusters based on reference occurrences. We show that our approach yields highly comparable results to a more general approach and allows for approximate gene cluster detection in parameter ranges currently not feasible for non-reference based approaches.