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Journal of Polymer Research

Erschienen in:

01.04.2015 | Original Paper

Electrospinning and antibacterial activity of chitosan-blended poly(lactic acid) nanofibers

verfasst von: Andri Hardiansyah, Hartanto Tanadi, Ming-Chien Yang, Ting-Yu Liu

Erschienen in: Journal of Polymer Research | Ausgabe 4/2015

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Abstract

In this study, chitosan-blended poly(lactic acid) (PLA) nanofibers were fabricated via electrospinning process by using a solvent composing of chloroform, water, acetic acid, and ethanol. In particular, the introduction of ethanol made acetic acid/water and chloroform miscible. The resultant chitosan-blended PLA nanofibers were subject to characterization including scanning electron microscope (SEM), UV-visible spectroscopy, fluorescence microscope and Fourier transform infrared (FTIR) spectroscopy. The average diameter of chitosan-blended PLA nanofibers decreased with increasing chitosan content. The minimum inhibitory concentration (MIC) of chitosan-blended PLA nanofibers against Eschericia coli was 0.015 g/mL when chitosan to PLA ratio was 4 wt%. Furthermore, chitosan-blended PLA nanofibers exhibited no cytotoxicity to the L-929 cells, suggesting cytocompatibility. These results show that chitosan and PLA can be blended without using highly-toxic solvent and the electrospun chitosan-blended PLA nanofibers can potentially be employed for biomedical applications.

Vorheriger Artikel Generation of stable carbocations in polydiphenylenesulfophthalide and ortho-substituted polytriarylcarbinols upon water desorption

Nächster Artikel Photo-induced atom transfer radical polymerization in ionic liquid

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Titel: Electrospinning and antibacterial activity of chitosan-blended poly(lactic acid) nanofibers
verfasst von: Andri Hardiansyah
Hartanto Tanadi
Ming-Chien Yang
Ting-Yu Liu
Publikationsdatum: 01.04.2015
Verlag: Springer Netherlands
Erschienen in: Journal of Polymer Research / Ausgabe 4/2015
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-015-0704-8

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