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Erschienen in:
Engineering in Translational Medicine: An Introduction Kapitel lesen Erstes Kapitel lesen

2014 | OriginalPaper | Buchkapitel

35. Engineering AApeptides for Translational Medicine

verfasst von : Haifan Wu, Jianfeng Cai

Erschienen in: Engineering in Translational Medicine

Verlag: Springer London

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Abstract

Peptidomimetics, designed to mimic the structure and function of bioactive peptides, have found enormous application in the development of translational medicine. The emergence of novel peptidomimetics will continue to expand their biological applications. We recently have developed a new class of peptidomimetics termed “AApeptides” in order to advance the field of peptidomimetics. AApeptides have unnatural backbones and are resistant to protease degradation. In addition, they have limitless ability for derivatization. Their synthesis is also straightforward, augmenting their potential in biomedical applications. In this chapter, we try to summarize the chemical development of AApeptides and highlight examples of AApeptides as new unnatural peptidomimetics in the identification of potential therapeutics for translational medicine, such as antimicrobial agents and anticancer agents. At the end, a perspective is also discussed on the future development of AApeptides to fulfill their biological applications.

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Vorheriges Kapitel Engineering of Photomanipulatable Hydrogels for Translational Medicine
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Metadaten
Titel
Engineering AApeptides for Translational Medicine
verfasst von
Haifan Wu
Jianfeng Cai
Copyright-Jahr
2014
Verlag
Springer London
Buch
Engineering in Translational Medicine

Print ISBN: 978-1-4471-4371-0

Electronic ISBN: 978-1-4471-4372-7

Copyright-Jahr: 2014

DOI
https://doi.org/10.1007/978-1-4471-4372-7_35

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