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2014 | OriginalPaper | Buchkapitel

31. Engineering Small Animal Conformal Radiotherapy Systems

verfasst von : Magdalena Bazalova, Edward E. Graves

Erschienen in: Engineering in Translational Medicine

Verlag: Springer London

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Abstract

Small animal conformal radiotherapy platforms are important tools for translational research in the field of radiation oncology. It is crucial that the effects of radiotherapy on small animals are studied under the same conditions under which clinical radiotherapy is delivered. In this chapter, the engineering aspects of small animal radiotherapy systems, including the sources of radiation, beam collimation, and imaging techniques are described. An overview of the principal existing systems is given, and their current and future applications are discussed.

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Literatur
2.
Zurück zum Zitat Adler JR, Chang SD, Murphy MJ, Doty J, Geis P, Hancock SL (1997) The cyberknife: a frameless robotic system for radiosurgery. Stereotact Funct Neurosurg 69(1–4):124–128CrossRef Adler JR, Chang SD, Murphy MJ, Doty J, Geis P, Hancock SL (1997) The cyberknife: a frameless robotic system for radiosurgery. Stereotact Funct Neurosurg 69(1–4):124–128CrossRef
3.
Zurück zum Zitat Graves EE, Zhou H, Chatterjee R, Keall PJ, Gambhir SS, Contag CH, Boyer AL (2007) Design and evaluation of a variable aperture collimator for conformal radiotherapy of small animals using a microCT scanner. Med Phys 34(11):4359–4367. doi:10.1118/1.2789498 CrossRef Graves EE, Zhou H, Chatterjee R, Keall PJ, Gambhir SS, Contag CH, Boyer AL (2007) Design and evaluation of a variable aperture collimator for conformal radiotherapy of small animals using a microCT scanner. Med Phys 34(11):4359–4367. doi:10.​1118/​1.​2789498 CrossRef
5.
Zurück zum Zitat Yan G, Tian J, Zhu S, Dai Y, Qin C (2008) Fast cone-beam CT image reconstruction using GPU hardware. J X-Ray Sci Tech 16(4):225–234 Yan G, Tian J, Zhu S, Dai Y, Qin C (2008) Fast cone-beam CT image reconstruction using GPU hardware. J X-Ray Sci Tech 16(4):225–234
7.
Zurück zum Zitat Stojadinovic S, Low DA, Hope AJ, Vicic M, Deasy JO, Cui J, Khullar D, Parikh PJ, Malinowski KT, Izaguirre EW, Mutic S, Grigsby PW (2007) MicroRT: small animal conformal irradiator. Med Phys 34(12):4706–4716. doi:10.1118/1.2799887 CrossRef Stojadinovic S, Low DA, Hope AJ, Vicic M, Deasy JO, Cui J, Khullar D, Parikh PJ, Malinowski KT, Izaguirre EW, Mutic S, Grigsby PW (2007) MicroRT: small animal conformal irradiator. Med Phys 34(12):4706–4716. doi:10.​1118/​1.​2799887 CrossRef
8.
Zurück zum Zitat Tryggestad E, Armour M, Iordachita I, Verhaegen F, Wong JW (2009) A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform. Phys Med Biol 54(17):5341–5357. doi:10.1088/0031-9155/54/17/017 CrossRef Tryggestad E, Armour M, Iordachita I, Verhaegen F, Wong JW (2009) A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform. Phys Med Biol 54(17):5341–5357. doi:10.​1088/​0031-9155/​54/​17/​017 CrossRef
9.
Zurück zum Zitat Kawrakow I, Rogers DWO (2003) The EGSnrc code system: Monte Carlo simulation of electron and photon transport. NRCC Report PIRS-701, National Research Council, Ottawa, Canada Kawrakow I, Rogers DWO (2003) The EGSnrc code system: Monte Carlo simulation of electron and photon transport. NRCC Report PIRS-701, National Research Council, Ottawa, Canada
10.
Zurück zum Zitat Agostinelli S, Allison J, Amako K, Apostolakis J, Araujo H, Arce P, Asai M, Axen D, Banerjee S, Barrand G, Behner F, Bellagamba L, Boudreau J, Broglia L, Brunengo A, Burkhardt H, Chauvie S, Chuma J, Chytracek R, Cooperman G, Cosmo G, Degtyarenko P, Dell’Acqua A, Depaola G, Dietrich D, Enami R, Feliciello A, Ferguson C, Fesefeldt H, Folger G, Foppiano F, Forti A, Garelli S, Giani S, Giannitrapani R, Gibin D, Cadenas JJG, Gonzalez I, Abril GG, Greeniaus G, Greiner W, Grichine V, Grossheim A, Guatelli S, Gumplinger P, Hamatsu R, Hashimoto K, Hasui H, Heikkinen A, Howard A, Ivanchenko V, Johnson A, Jones FW, Kallenbach J, Kanaya N, Kawabata M, Kawabata Y, Kawaguti M, Kelner S, Kent P, Kimura A, Kodama T, Kokoulin R, Kossov M, Kurashige H, Lamanna E, Lampen T, Lara V, Lefebure V, Lei F, Liendl M, Lockman W, Longo F, Magni S, Maire M, Medernach E, Minamimoto K, de Freitas PM, Morita Y, Murakami K, Nagamatu M, Nartallo R, Nieminen P, Nishimura T, Ohtsubo K, Okamura M, O’Neale S, Oohata Y, Paech K, Perl J, Pfeiffer A, Pia MG, Ranjard F, Rybin A, Sadilov S, Di Salvo E, Santin G, Sasaki T, Savvas N, Sawada Y, Scherer S, Seil S, Sirotenko V, Smith D, Starkov N, Stoecker H, Sulkimo J, Takahata M, Tanaka S, Tcherniaev E, Tehrani ES, Tropeano M, Truscott P, Uno H, Urban L, Urban P, Verderi M, Walkden A, Wander W, Weber H, Wellisch JP, Wenaus T, Williams DC, Wright D, Yamada T, Yoshida H, Zschiesche D (2003) GEANT4-a simulation toolkit. Nucl Instrum Method Phys Res Sect A: Acceler Spectrom Det Assoc Equip 506(3):250–303. doi:10.1016/s0168-9002(03)01368-8 CrossRef Agostinelli S, Allison J, Amako K, Apostolakis J, Araujo H, Arce P, Asai M, Axen D, Banerjee S, Barrand G, Behner F, Bellagamba L, Boudreau J, Broglia L, Brunengo A, Burkhardt H, Chauvie S, Chuma J, Chytracek R, Cooperman G, Cosmo G, Degtyarenko P, Dell’Acqua A, Depaola G, Dietrich D, Enami R, Feliciello A, Ferguson C, Fesefeldt H, Folger G, Foppiano F, Forti A, Garelli S, Giani S, Giannitrapani R, Gibin D, Cadenas JJG, Gonzalez I, Abril GG, Greeniaus G, Greiner W, Grichine V, Grossheim A, Guatelli S, Gumplinger P, Hamatsu R, Hashimoto K, Hasui H, Heikkinen A, Howard A, Ivanchenko V, Johnson A, Jones FW, Kallenbach J, Kanaya N, Kawabata M, Kawabata Y, Kawaguti M, Kelner S, Kent P, Kimura A, Kodama T, Kokoulin R, Kossov M, Kurashige H, Lamanna E, Lampen T, Lara V, Lefebure V, Lei F, Liendl M, Lockman W, Longo F, Magni S, Maire M, Medernach E, Minamimoto K, de Freitas PM, Morita Y, Murakami K, Nagamatu M, Nartallo R, Nieminen P, Nishimura T, Ohtsubo K, Okamura M, O’Neale S, Oohata Y, Paech K, Perl J, Pfeiffer A, Pia MG, Ranjard F, Rybin A, Sadilov S, Di Salvo E, Santin G, Sasaki T, Savvas N, Sawada Y, Scherer S, Seil S, Sirotenko V, Smith D, Starkov N, Stoecker H, Sulkimo J, Takahata M, Tanaka S, Tcherniaev E, Tehrani ES, Tropeano M, Truscott P, Uno H, Urban L, Urban P, Verderi M, Walkden A, Wander W, Weber H, Wellisch JP, Wenaus T, Williams DC, Wright D, Yamada T, Yoshida H, Zschiesche D (2003) GEANT4-a simulation toolkit. Nucl Instrum Method Phys Res Sect A: Acceler Spectrom Det Assoc Equip 506(3):250–303. doi:10.​1016/​s0168-9002(03)01368-8 CrossRef
11.
Zurück zum Zitat Pelowitz DB (2008) MCNPX User's Manual, Version 2.6.0. Los Alamos National Laboratory Report No. LA-CP-07-1473, Los Alamos, NM Pelowitz DB (2008) MCNPX User's Manual, Version 2.6.0. Los Alamos National Laboratory Report No. LA-CP-07-1473, Los Alamos, NM
12.
Zurück zum Zitat Bazalova M, Zhou H, Keall PJ, Graves EE (2009) Kilovoltage beam Monte Carlo dose calculations in submillimeter voxels for small animal radiotherapy. Med Phys 36(11):4991–4999. doi:10.1118/1.3238465 CrossRef Bazalova M, Zhou H, Keall PJ, Graves EE (2009) Kilovoltage beam Monte Carlo dose calculations in submillimeter voxels for small animal radiotherapy. Med Phys 36(11):4991–4999. doi:10.​1118/​1.​3238465 CrossRef
13.
Zurück zum Zitat Bazalova M, Graves EE (2011) The importance of tissue segmentation for dose calculations for kilovoltage radiation therapy. Med Phys 38(6):3039–3049. doi:10.1118/1.3589138 CrossRef Bazalova M, Graves EE (2011) The importance of tissue segmentation for dose calculations for kilovoltage radiation therapy. Med Phys 38(6):3039–3049. doi:10.​1118/​1.​3589138 CrossRef
14.
Zurück zum Zitat Motomura AR, Bazalova M, Zhou H, Keall PJ, Graves EE (2010) Investigation of the effects of treatment planning variables in small animal radiotherapy dose distributions. Med Phys 37(2):590–599. doi:10.1118/1.3276738 CrossRef Motomura AR, Bazalova M, Zhou H, Keall PJ, Graves EE (2010) Investigation of the effects of treatment planning variables in small animal radiotherapy dose distributions. Med Phys 37(2):590–599. doi:10.​1118/​1.​3276738 CrossRef
15.
Zurück zum Zitat Ma CM, Coffey CW, DeWerd LA, Liu C, Nath R, Seltzer SM, Seuntjens JP (2001) AAPM protocol for 40–300 kV x-ray beam dosimetry in radiotherapy and radiobiology. Med Phys 28(6):868–893. doi:10.1118/1.1374247 CrossRef Ma CM, Coffey CW, DeWerd LA, Liu C, Nath R, Seltzer SM, Seuntjens JP (2001) AAPM protocol for 40–300 kV x-ray beam dosimetry in radiotherapy and radiobiology. Med Phys 28(6):868–893. doi:10.​1118/​1.​1374247 CrossRef
16.
17.
Zurück zum Zitat Wong J, Armour E, Kazanzides P, Iordachita U, Tryggestad E, Deng H, Matinfar M, Kennedy C, Liu ZJ, Chan T, Gray O, Verhaegen F, McNutt T, Ford E, DeWeese TL (2008) High-resolution, small animal radiation research platform with X-ray tomographic guidance capabilities. Int J Rad Oncol Biol Phys 71(5):1591–1599. doi:10.1016/j.ijrobp.2008.04.025 CrossRef Wong J, Armour E, Kazanzides P, Iordachita U, Tryggestad E, Deng H, Matinfar M, Kennedy C, Liu ZJ, Chan T, Gray O, Verhaegen F, McNutt T, Ford E, DeWeese TL (2008) High-resolution, small animal radiation research platform with X-ray tomographic guidance capabilities. Int J Rad Oncol Biol Phys 71(5):1591–1599. doi:10.​1016/​j.​ijrobp.​2008.​04.​025 CrossRef
18.
19.
Zurück zum Zitat Clarkson R, Lindsay PE, Ansell S, Wilson G, Jelveh S, Hill RP, Jaffray DA (2011) Characterization of image quality and image-guidance performance of a preclinical microirradiator. Med Phys 38(2):845–856. doi:10.1118/1.3533947 CrossRef Clarkson R, Lindsay PE, Ansell S, Wilson G, Jelveh S, Hill RP, Jaffray DA (2011) Characterization of image quality and image-guidance performance of a preclinical microirradiator. Med Phys 38(2):845–856. doi:10.​1118/​1.​3533947 CrossRef
20.
Zurück zum Zitat Zhou H, Rodriguez M, van den Haak F, Nelson G, Jogani R, Xu J, Zhu X, Xian Y, Tran PT, Felsher DW, Keall PJ, Graves EE (2010) Development of a micro-computed tomography–based image-guided conformal radiotherapy system for small animals. Int J Rad Oncol Biol Phys 77(2):384–391CrossRef Zhou H, Rodriguez M, van den Haak F, Nelson G, Jogani R, Xu J, Zhu X, Xian Y, Tran PT, Felsher DW, Keall PJ, Graves EE (2010) Development of a micro-computed tomography–based image-guided conformal radiotherapy system for small animals. Int J Rad Oncol Biol Phys 77(2):384–391CrossRef
21.
Zurück zum Zitat Pidikiti R, Stojadinovic S, Speiser M, Song KH, Hager F, Saha D, Solberg TD (2011) Dosimetric characterization of an image-guided stereotactic small animal irradiator. Phys Med Biol 56(8):2585–2599. doi:10.1088/0031-9155/56/8/016 CrossRef Pidikiti R, Stojadinovic S, Speiser M, Song KH, Hager F, Saha D, Solberg TD (2011) Dosimetric characterization of an image-guided stereotactic small animal irradiator. Phys Med Biol 56(8):2585–2599. doi:10.​1088/​0031-9155/​56/​8/​016 CrossRef
22.
23.
Zurück zum Zitat Kiehl EL, Stojadinovic S, Malinowski KT, Limbrick D, Jost SC, Garbow JR, Rubin JB, Deasy JO, Khullar D, Izaguirre EW, Parikh PJ, Low DA, Hope AJ (2008) Feasibility of small animal cranial irradiation with the microRT system. Med Phys 35(10):4735–4743. doi:10.1118/1.2977762 CrossRef Kiehl EL, Stojadinovic S, Malinowski KT, Limbrick D, Jost SC, Garbow JR, Rubin JB, Deasy JO, Khullar D, Izaguirre EW, Parikh PJ, Low DA, Hope AJ (2008) Feasibility of small animal cranial irradiation with the microRT system. Med Phys 35(10):4735–4743. doi:10.​1118/​1.​2977762 CrossRef
24.
Zurück zum Zitat Redmond KJ, Achanta P, Grossman SA, Armour M, Reyes J, Kleinberg L, Tryggestad E, Quinones-Hinojosa A, Ford EC (2011) A radiotherapy technique to limit dose to neural progenitor cell niches without compromising tumor coverage. J Neur Oncol 104(2):579–587. doi:10.1007/s11060-011-0530-8 CrossRef Redmond KJ, Achanta P, Grossman SA, Armour M, Reyes J, Kleinberg L, Tryggestad E, Quinones-Hinojosa A, Ford EC (2011) A radiotherapy technique to limit dose to neural progenitor cell niches without compromising tumor coverage. J Neur Oncol 104(2):579–587. doi:10.​1007/​s11060-011-0530-8 CrossRef
25.
Zurück zum Zitat Lo VCK, Akens MK, Moore S, Yee AJM, Wilson BC, Whyne CM (2012) Beyond radiation therapy: photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo model. Breast Cancer Res Treat 135(2):391–401. doi:10.1007/s10549-012-2146-x CrossRef Lo VCK, Akens MK, Moore S, Yee AJM, Wilson BC, Whyne CM (2012) Beyond radiation therapy: photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo model. Breast Cancer Res Treat 135(2):391–401. doi:10.​1007/​s10549-012-2146-x CrossRef
27.
Zurück zum Zitat Chithrani DB, Jelveh S, Jalali F, van Prooijen M, Allen C, Bristow RG, Hill RP, Jaffray DA (2010) Gold nanoparticles as radiation sensitizers in cancer therapy. Radiat Res 173(6):719–728. doi:10.1667/rr1984.1 CrossRef Chithrani DB, Jelveh S, Jalali F, van Prooijen M, Allen C, Bristow RG, Hill RP, Jaffray DA (2010) Gold nanoparticles as radiation sensitizers in cancer therapy. Radiat Res 173(6):719–728. doi:10.​1667/​rr1984.​1 CrossRef
Metadaten
Titel
Engineering Small Animal Conformal Radiotherapy Systems
verfasst von
Magdalena Bazalova
Edward E. Graves
Copyright-Jahr
2014
Verlag
Springer London
DOI
https://doi.org/10.1007/978-1-4471-4372-7_31

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