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Erschienen in:
2019 | OriginalPaper | Buchkapitel
Fractional Reaction Diffusion Model for Parkinson’s Disease
verfasst von : Hardik Joshi, Brajesh Kumar Jha
Erschienen in: Proceedings of the International Conference on ISMAC in Computational Vision and Bio-Engineering 2018 (ISMAC-CVB)
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Abstract
Calcium (Ca2+) ion known as a second messenger, involve in variety of signalling process, and directly link with the intracellular calcium concentration ([Ca2+]) that are continuously remodelled for the survival of the nerve cell. Buffer, also refer as a protein, react with Ca2+ and significantly lower down the intracellular [Ca2+] in nerve cell. There are numerous signalling processes in mammalian brain which can initiate at the high level of intracellular [Ca2+]. Voltage gated calcium channel (VGCC), and ryanodine receptor (RyR) are work as an outward source of Ca2+ which initiate, and sustain the signalling process for smooth functioning of the cells. Parkinson’s disease (PD) is a brain disorder of the central nervous system accompanied with the alteration of the signalling process. In present paper, a one dimensional fractional reaction diffusion model is consider to understand the physiological role of buffer, VGCC, and RyR in view of the PD.