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Journal of Materials Science

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19.07.2021 | Materials for life sciences

Graphene oxide/polyethylene glycol aerogel reinforced with grape seed extracts as wound dressing

verfasst von: Jessica Borges-Vilches, Javiera Poblete, Fernando Gajardo, Claudio Aguayo, Katherina Fernández

Erschienen in: Journal of Materials Science | Ausgabe 28/2021

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Abstract

In this study, graphene oxide (GO) and polyethylene glycol (PEG) composite aerogels were developed by non-covalent interactions, and then, grape seed extracts (Ex), high in proanthocyanidins (PAs), were incorporated into these materials to evaluate their hemostatic performance. The morphology, chemical features, surface charge, aerogel/blood cell interactions, absorption and blood coagulation capacity, cytotoxicity and extract release from the aerogels were investigated. The aerogels showed heterogeneous porous structures capable of absorbing more than 20 times their weight when in contact with fresh human blood and water. No significant differences were observed in the physical properties of the aerogels with the inclusion of grape seed extracts. However, the effects of this natural compound were favorable to blood coagulation clotting, increasing the coagulated blood content from 77% to 84% for GO-PEG and GO-PEG/Ex aerogels after 30 s of reaction, respectively. The aerogel/blood cell interactions demonstrated the adhesion of red blood cells (RBCs) and leukocytes on the aerogel’s surface, these interactions being favored by the inclusion of grape extracts on GO-PEG matrices. The aerogels showed proliferative effects on human dermal fibroblast cells, which could be associated with the presence of PEG and PAs in their matrices. Finally, the PAs release studies from the GO-PEG/Ex aerogel matrix showed that a combined mechanism of Fickian and non-Fickian diffusion governed these release processes. This study provides a new material whose hemocompatibility properties and phytodrug release ability support its application as a hemostatic device.

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Vorheriger Artikel Rapid fabrication of hierarchical porous SiC/C hybrid structure: toward high-performance capacitive energy storage with ultrahigh cyclability

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Titel: Graphene oxide/polyethylene glycol aerogel reinforced with grape seed extracts as wound dressing
verfasst von: Jessica Borges-Vilches
Javiera Poblete
Fernando Gajardo
Claudio Aguayo
Katherina Fernández
Publikationsdatum: 19.07.2021
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 28/2021
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-021-06297-z

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