1988 | OriginalPaper | Buchkapitel
HPD Mediated Photochemotherapy for Selective Treatment of Leukemic Cells VS Normal Cells
verfasst von : T. Patrice, M. T. Foultier, V. Praloran, D. Cloarec, L. Le Bodic
Erschienen in: LASER Optoelectronics in Medicine
Verlag: Springer Berlin Heidelberg
Enthalten in: Professional Book Archive
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
As photochemotherapy of solid tumors is rapidly develloping recent studies suggested that in-vitro photochemotherapy mediated by HPD could be more efficient on leukemic cells than normal cells (1), (2) and this represent a way of cell selection. In order to demonstrate this phenomenon we studied the phototoxicity on both leukemic cells (L1210) and normal syngeneic hemoprogenitors. We varied three culture parameters: time incubation of the cells with HPD, temperature of the medium during incubation and treatment of the cells, laser dose fractionation in 2 or 3. For each condition 3 separates experiments in triplicate have been performed, and each experiment involved simultaneously both cell types for 2 or 3 laser energy levels.