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2014 | OriginalPaper | Buchkapitel

Hypoglycemia Prevention Using Low Glucose Suspend Systems

verfasst von : B. Wayne Bequette

Erschienen in: Data-driven Modeling for Diabetes

Verlag: Springer Berlin Heidelberg

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Abstract

The fear of nocturnal hypoglycemia was one of the main motivations behind the development of continuous glucose monitors (CGM) and hypoglycemic alarms. Since many individuals do not awake to these alarms, the next step is to implement a low glucose suspend (LGS) algorithm that shuts off the insulin infusion pump to avoid hypoglycemia. A threshold-based LGS simply shuts off the pump when the CGM signal has violated a lower limit on glucose. A predictive LGS shuts off the pump when a glucose threshold is predicted to occur within a specified time limit, or horizon. A review of algorithms hypoglycemic predictors/alarms is followed by a presentation of threshold and predictive LGS algorithms. Finally, an overview of the implementation challenges that remain is provided.

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Literatur
1.
Zurück zum Zitat Agrawal P, Welsh JB, Kannard B, Askari S, Yang Q, Kaufman FR (2011) Usage and effectiveness of the low glucose suspend feature of the Medtronic Paradigm Veo insulin pump. J Diabetes Sci Technol 5(5):1137–1141CrossRef Agrawal P, Welsh JB, Kannard B, Askari S, Yang Q, Kaufman FR (2011) Usage and effectiveness of the low glucose suspend feature of the Medtronic Paradigm Veo insulin pump. J Diabetes Sci Technol 5(5):1137–1141CrossRef
2.
Zurück zum Zitat Bayrak ES, Turksoy K, Cinar A, Quinn L, Littlejohn E, Rollins D (2013) Hypoglycemia early alarm systems based on recursive autoregressive partial least squares. J Diabetes Sci Technol 7(1):206–214CrossRef Bayrak ES, Turksoy K, Cinar A, Quinn L, Littlejohn E, Rollins D (2013) Hypoglycemia early alarm systems based on recursive autoregressive partial least squares. J Diabetes Sci Technol 7(1):206–214CrossRef
3.
Zurück zum Zitat Baysal N, Cameron F, Buckingham BA, Wilson DM, Chase HP, Bequette BW (2013a) Nocturnal continuous glucose monitor signal attenuation: an outpatient study. J Diabetes Sci Technol 7(1):A9 (Abstract from presentation at the 2012 diabetes technology meeting, Bethesda) Baysal N, Cameron F, Buckingham BA, Wilson DM, Chase HP, Bequette BW (2013a) Nocturnal continuous glucose monitor signal attenuation: an outpatient study. J Diabetes Sci Technol 7(1):A9 (Abstract from presentation at the 2012 diabetes technology meeting, Bethesda)
4.
Zurück zum Zitat Baysal N, Cameron F, Buckingham BA, Wilson DM, Bequette BW (2013b) Detecting sensor and insulin infusion set anomalies in an artificial pancreas. In: Proceedings of the 2013 American control conference, Washington, DC, pp 2935–2939 Baysal N, Cameron F, Buckingham BA, Wilson DM, Bequette BW (2013b) Detecting sensor and insulin infusion set anomalies in an artificial pancreas. In: Proceedings of the 2013 American control conference, Washington, DC, pp 2935–2939
5.
Zurück zum Zitat Bequette BW (2010) Continuous glucose monitoring: real-time algorithms for calibration, filtering and alarms. J Diabetes Sci Technol 4(2):404–418CrossRef Bequette BW (2010) Continuous glucose monitoring: real-time algorithms for calibration, filtering and alarms. J Diabetes Sci Technol 4(2):404–418CrossRef
6.
Zurück zum Zitat Bequette BW (2012) Challenges and progress in the development of a closed-loop artificial pancreas. Annu Rev Control 36:255–266CrossRef Bequette BW (2012) Challenges and progress in the development of a closed-loop artificial pancreas. Annu Rev Control 36:255–266CrossRef
7.
Zurück zum Zitat Bremer T, Gough DA (1999) Is blood glucose predictable from previous values? A solicitation for data. Diabetes 48(3):445–451CrossRef Bremer T, Gough DA (1999) Is blood glucose predictable from previous values? A solicitation for data. Diabetes 48(3):445–451CrossRef
8.
Zurück zum Zitat Breton M, Farret A, Bruttomesso D, Anderson S, Magni L, Patek S, Dalla Man C, Place J, DeMartini S, Del Favero S, Toffanin C, Hughes C, Dassau E, Zisser H, Doyle III FJ, de Nicolao G, Avogaro A, Cobelli C, Renard E, Kovatchev on behalf of the International Artificial Pancreas (IAP) Study Group (2012) Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia. Diabetes 61(9):2230–2237 Breton M, Farret A, Bruttomesso D, Anderson S, Magni L, Patek S, Dalla Man C, Place J, DeMartini S, Del Favero S, Toffanin C, Hughes C, Dassau E, Zisser H, Doyle III FJ, de Nicolao G, Avogaro A, Cobelli C, Renard E, Kovatchev on behalf of the International Artificial Pancreas (IAP) Study Group (2012) Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia. Diabetes 61(9):2230–2237
9.
Zurück zum Zitat Buckingham B, Block J, Burdick J, Kalajian A, Kollman C, Choy M, Wilson DM, Chase HP (2005) Diabetes research in childrens network: response to nocturnal alarms using a real-time glucose sensor. Diabetes Technol Ther 7:440–447CrossRef Buckingham B, Block J, Burdick J, Kalajian A, Kollman C, Choy M, Wilson DM, Chase HP (2005) Diabetes research in childrens network: response to nocturnal alarms using a real-time glucose sensor. Diabetes Technol Ther 7:440–447CrossRef
10.
Zurück zum Zitat Buckingham B, Wilson DM, Lecher T, Hanas R, Kaiserman K, Cameron F (2008) Duration of nocturnal hypoglycemia before seizures. Diabetes Care 31(11):2110–2112CrossRef Buckingham B, Wilson DM, Lecher T, Hanas R, Kaiserman K, Cameron F (2008) Duration of nocturnal hypoglycemia before seizures. Diabetes Care 31(11):2110–2112CrossRef
11.
Zurück zum Zitat Buckingham B, Cobry E, Clinton P, Gage V, Caswell K, Kunselman E, Cameron F, Chase HP (2009) Preventing hypoglycemia using predictive alarm algorithms and insulin pump suspension. Diabetes Tech Ther 11(2):93–97CrossRef Buckingham B, Cobry E, Clinton P, Gage V, Caswell K, Kunselman E, Cameron F, Chase HP (2009) Preventing hypoglycemia using predictive alarm algorithms and insulin pump suspension. Diabetes Tech Ther 11(2):93–97CrossRef
12.
Zurück zum Zitat Buckingham B, Chase HP, Dassau E, Cobry E, Clinton P, Gage V, Caswell K, Wilkinson J, Cameron F, Lee H, Bequette BW, Doyle FJ III (2010) Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension. Diabetes Care 33(5):1013–1018CrossRef Buckingham B, Chase HP, Dassau E, Cobry E, Clinton P, Gage V, Caswell K, Wilkinson J, Cameron F, Lee H, Bequette BW, Doyle FJ III (2010) Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension. Diabetes Care 33(5):1013–1018CrossRef
13.
Zurück zum Zitat Buckingham BA, Cameron F, Calhoun P, Maahs DM, Wilson DM, Chase HP, Bequette BW, Lum J, Sibayan J, Beck RW, Kollman C (2013) Outpatient safety assessment of an in-home predictive low-glucose suspend system with T1 D subjects at elevated risk of nocturnal hypoglycemia. Diabetes Technol Ther 15(8):622–627CrossRef Buckingham BA, Cameron F, Calhoun P, Maahs DM, Wilson DM, Chase HP, Bequette BW, Lum J, Sibayan J, Beck RW, Kollman C (2013) Outpatient safety assessment of an in-home predictive low-glucose suspend system with T1 D subjects at elevated risk of nocturnal hypoglycemia. Diabetes Technol Ther 15(8):622–627CrossRef
14.
Zurück zum Zitat Cameron F, Wilson DM, Buckingham BA, Arzumanyan H, Benzsi K, Chase HP, Lum J, Maahs DM, Calhoun PM, Bequette BW (2012) In-patient studies of a Kalman filter based predictive pump shut-off algorithm. J Diabetes Sci Technol 6(5):1142–1147CrossRef Cameron F, Wilson DM, Buckingham BA, Arzumanyan H, Benzsi K, Chase HP, Lum J, Maahs DM, Calhoun PM, Bequette BW (2012) In-patient studies of a Kalman filter based predictive pump shut-off algorithm. J Diabetes Sci Technol 6(5):1142–1147CrossRef
15.
Zurück zum Zitat Cameron F, Buckingham BA, Wilson DM, Chase HP, Bequette BW (2013) Adding hyperglycemia mitigation to predictive low glucose suspension. In: Presented at the 73rd scientific sessions of the American Diabetes Association, Chicago Cameron F, Buckingham BA, Wilson DM, Chase HP, Bequette BW (2013) Adding hyperglycemia mitigation to predictive low glucose suspension. In: Presented at the 73rd scientific sessions of the American Diabetes Association, Chicago
16.
Zurück zum Zitat Cengiz E, Swan KL, Tamborlane WV, Steil GM, Steffen AT, Weinzimer SA (2009) Is an automatic pump suspension feature safe for children with type 1 diabetes An exploratory analysis with a closed-loop system. Diabetes Technol Ther 11(4):207–210CrossRef Cengiz E, Swan KL, Tamborlane WV, Steil GM, Steffen AT, Weinzimer SA (2009) Is an automatic pump suspension feature safe for children with type 1 diabetes An exploratory analysis with a closed-loop system. Diabetes Technol Ther 11(4):207–210CrossRef
17.
Zurück zum Zitat Choudhary P, Shin J, Wang Y, Evans ML, Hammond PJ, Kerr D, Shaw JAM, Pickup JC, Amiel SA (2011) Insulin pump therapy with automated insulin suspension in response to hypoglycemia. Reduction in nocturnal hypoglycemia in those at greatest risk. Diabetes Care 34:2023–2025CrossRef Choudhary P, Shin J, Wang Y, Evans ML, Hammond PJ, Kerr D, Shaw JAM, Pickup JC, Amiel SA (2011) Insulin pump therapy with automated insulin suspension in response to hypoglycemia. Reduction in nocturnal hypoglycemia in those at greatest risk. Diabetes Care 34:2023–2025CrossRef
18.
Zurück zum Zitat Danne T, Kordonouri O, Holder M, Haberland H, Golembowski S, Remus K, Blasig S, Wadien T, Zierow S, Hartmann R, Thomas A (2011) Prevention of hypoglycemia by using low glucose suspend function in sensor-augmented pump therapy. Diabetes Technol Ther 13(11):1129–1134CrossRef Danne T, Kordonouri O, Holder M, Haberland H, Golembowski S, Remus K, Blasig S, Wadien T, Zierow S, Hartmann R, Thomas A (2011) Prevention of hypoglycemia by using low glucose suspend function in sensor-augmented pump therapy. Diabetes Technol Ther 13(11):1129–1134CrossRef
19.
Zurück zum Zitat Dassau E, Cameron F, Lee H, Bequette BW, Zisser H, Jovanovic L, Chase HP, Wilson DM, Buckingham BA, Doyle FJ III (2010) Real-time hypoglycemia prediction suite using continuous glucose monitoring: a safety net for the artificial pancreas. Diabetes Care 33(6):1249–1254CrossRef Dassau E, Cameron F, Lee H, Bequette BW, Zisser H, Jovanovic L, Chase HP, Wilson DM, Buckingham BA, Doyle FJ III (2010) Real-time hypoglycemia prediction suite using continuous glucose monitoring: a safety net for the artificial pancreas. Diabetes Care 33(6):1249–1254CrossRef
20.
Zurück zum Zitat Davey RJ, Jones TW, Fournier PA (2010) Effect of short-term use of a continuous glucose monitoring system with a real-time glucose display and a low glucose alarm on incidence and duration of hypoglycemia in a home setting in type 1 diabetes mellitus. J Diabetes Sci Technol 4(6):1457–1464CrossRef Davey RJ, Jones TW, Fournier PA (2010) Effect of short-term use of a continuous glucose monitoring system with a real-time glucose display and a low glucose alarm on incidence and duration of hypoglycemia in a home setting in type 1 diabetes mellitus. J Diabetes Sci Technol 4(6):1457–1464CrossRef
21.
Zurück zum Zitat Elleri G, Allen JM, Nodale M, Wilinska ME, Acerini CL, Dunger DB, Hovorka R (2010) Suspended insulin infusion during overnight closed-loop glucose control in children and adolescents with Type 1 diabetes. Diabet Med 27:480–484CrossRef Elleri G, Allen JM, Nodale M, Wilinska ME, Acerini CL, Dunger DB, Hovorka R (2010) Suspended insulin infusion during overnight closed-loop glucose control in children and adolescents with Type 1 diabetes. Diabet Med 27:480–484CrossRef
22.
Zurück zum Zitat Eren-Oruklu M, Cinar A, Quinn L, Smith D (2009) Estimation of future glucose concentrations with subject-specific recursive linear models. Diabetes Technol Ther 11(4):243–253CrossRef Eren-Oruklu M, Cinar A, Quinn L, Smith D (2009) Estimation of future glucose concentrations with subject-specific recursive linear models. Diabetes Technol Ther 11(4):243–253CrossRef
23.
Zurück zum Zitat Eren-Oruklu M, Cinar A, Quinn L (2010) Hypoglycemia prediction with subject-specific recursive time-series models. J Diabetes Sci Technol 4(1):25–33CrossRef Eren-Oruklu M, Cinar A, Quinn L (2010) Hypoglycemia prediction with subject-specific recursive time-series models. J Diabetes Sci Technol 4(1):25–33CrossRef
24.
Zurück zum Zitat Eren-Oruklu M, Cinar A, Rollins DK, Quinn L (2012) Adaptive system identification for estimating future glucose concentrations and hypoglycemia alarms. Automatica 48:1892–1897MATHMathSciNetCrossRef Eren-Oruklu M, Cinar A, Rollins DK, Quinn L (2012) Adaptive system identification for estimating future glucose concentrations and hypoglycemia alarms. Automatica 48:1892–1897MATHMathSciNetCrossRef
25.
Zurück zum Zitat Facchinetti A, Sparacino G, Cobelli C (2010) An on-line self-tuneable method to denoise CGM sensor data. IEEE Tran Biomed Eng 57(3):634–641CrossRef Facchinetti A, Sparacino G, Cobelli C (2010) An on-line self-tuneable method to denoise CGM sensor data. IEEE Tran Biomed Eng 57(3):634–641CrossRef
26.
Zurück zum Zitat Gani A, Gribok AV, Rajaraman S, Ward WK, Reifman J (2009) Predicting subcutaneous glucose concentration in humans: data-driven glucose modeling. IEEE Trans Biomed Eng 56(2):246–254CrossRef Gani A, Gribok AV, Rajaraman S, Ward WK, Reifman J (2009) Predicting subcutaneous glucose concentration in humans: data-driven glucose modeling. IEEE Trans Biomed Eng 56(2):246–254CrossRef
27.
Zurück zum Zitat Garg S, Brazg R, Bailey TS, Buckingham BA, Slover RH, Klonoff DC et al (2012) Reduction in duration of hypoglycemia by automatic suspension of insulin delivery: the in-clinic ASPIRE study. Diabetes Technol Ther 14(3):205–209CrossRef Garg S, Brazg R, Bailey TS, Buckingham BA, Slover RH, Klonoff DC et al (2012) Reduction in duration of hypoglycemia by automatic suspension of insulin delivery: the in-clinic ASPIRE study. Diabetes Technol Ther 14(3):205–209CrossRef
28.
Zurück zum Zitat Grosman B, Dassau E, Zisser HC, Jovanovic L, Doyle FJ III (2010) Zone model predictive control: a strategy to minimize hyper- and hypoglycemic events. J Diabetes Sci Technol 4:961–975CrossRef Grosman B, Dassau E, Zisser HC, Jovanovic L, Doyle FJ III (2010) Zone model predictive control: a strategy to minimize hyper- and hypoglycemic events. J Diabetes Sci Technol 4:961–975CrossRef
29.
Zurück zum Zitat Harvey RA, Dassau E, Zisser H, Seborg DE, Jovanovic L, Doyle FJ III (2012) Design of the health monitoring system for the artificial pancreas: low glucose prediction module. J Diabetes Sci Technol 6(6):1345–1354CrossRef Harvey RA, Dassau E, Zisser H, Seborg DE, Jovanovic L, Doyle FJ III (2012) Design of the health monitoring system for the artificial pancreas: low glucose prediction module. J Diabetes Sci Technol 6(6):1345–1354CrossRef
30.
Zurück zum Zitat Hughes CS, Patek SD, Breton MD, Kovatchev BP (2010) Hypoglycemia prevention via pump attenuation and red-yellow-green ‘‘traffic’’ lights using continuous glucose monitoring and infusion pump data. J Diabetes Sci Technol 4(5):1146–1155CrossRef Hughes CS, Patek SD, Breton MD, Kovatchev BP (2010) Hypoglycemia prevention via pump attenuation and red-yellow-green ‘‘traffic’’ lights using continuous glucose monitoring and infusion pump data. J Diabetes Sci Technol 4(5):1146–1155CrossRef
31.
Zurück zum Zitat Hughes-Karvetski C, Patek SD, Breton MD, Kovatchev BP (2013) Historical data enhances safety supervision system performance in T1 DM insulin therapy risk management. Comput Methods Programs Biomed 109(2):220–225CrossRef Hughes-Karvetski C, Patek SD, Breton MD, Kovatchev BP (2013) Historical data enhances safety supervision system performance in T1 DM insulin therapy risk management. Comput Methods Programs Biomed 109(2):220–225CrossRef
32.
Zurück zum Zitat JDRF CGM Study Group (2010) Prolonged nocturnal hypoglycemia is common during 12 months of continuous glucose monitoring in children and adults with type 1 diabetes. Diabetes Care 33(5):1004–1008CrossRef JDRF CGM Study Group (2010) Prolonged nocturnal hypoglycemia is common during 12 months of continuous glucose monitoring in children and adults with type 1 diabetes. Diabetes Care 33(5):1004–1008CrossRef
34.
Zurück zum Zitat Knobbe EJ, Buckingham BA (2005) The extended Kalman filter for continuous glucose monitoring. Diabetes Technol Ther 7(1):15–27CrossRef Knobbe EJ, Buckingham BA (2005) The extended Kalman filter for continuous glucose monitoring. Diabetes Technol Ther 7(1):15–27CrossRef
35.
Zurück zum Zitat Kovatchev B, Patek S, Dassau E, Doyle FJ III, Magni L, De Nicolao G, Cobelli C, The Juvenile Diabetes Research Foundation Artificial Pancreas Consortium (2009) Control to range for diabetes: functionality and modular architecture. J Diabetes Sci Technol 3(5):1058–1065 Kovatchev B, Patek S, Dassau E, Doyle FJ III, Magni L, De Nicolao G, Cobelli C, The Juvenile Diabetes Research Foundation Artificial Pancreas Consortium (2009) Control to range for diabetes: functionality and modular architecture. J Diabetes Sci Technol 3(5):1058–1065
36.
Zurück zum Zitat Ly TT, Nicholas JA, Retterath A, Davis EA, Jones TW (2012) Analysis of glucose responses to automated insulin suspension with sensor-augmented pump therapy. Diabetes Care 35:1462–1465CrossRef Ly TT, Nicholas JA, Retterath A, Davis EA, Jones TW (2012) Analysis of glucose responses to automated insulin suspension with sensor-augmented pump therapy. Diabetes Care 35:1462–1465CrossRef
37.
Zurück zum Zitat Palerm CC, Bequette BW (2007) Hypoglycemia detection and prediction using continuous glucose monitoring—a study on hypoglycemic clamp data. J Diabetes Sci Technol 1(5):624–629CrossRef Palerm CC, Bequette BW (2007) Hypoglycemia detection and prediction using continuous glucose monitoring—a study on hypoglycemic clamp data. J Diabetes Sci Technol 1(5):624–629CrossRef
38.
Zurück zum Zitat Patek SD, Magni L, Dassau E, Karvetski CH, Toffanin C, de Nicolao G, del Favero S, Breton M, Dalla Man C, Renard E, Zisser H, Doyle III FJ, Cobelli C, Kovatchev BP (2012) Modular closed-loop control of diabetes. IEEE Trans Biomed Eng 59(11):2986–2999 Patek SD, Magni L, Dassau E, Karvetski CH, Toffanin C, de Nicolao G, del Favero S, Breton M, Dalla Man C, Renard E, Zisser H, Doyle III FJ, Cobelli C, Kovatchev BP (2012) Modular closed-loop control of diabetes. IEEE Trans Biomed Eng 59(11):2986–2999
39.
Zurück zum Zitat Pickup JC (2011) Semi-closed-loop insulin delivery systems: early experience with low-glucose insulin suspend pumps. Diabetes Technol Ther 13(7):695–698CrossRef Pickup JC (2011) Semi-closed-loop insulin delivery systems: early experience with low-glucose insulin suspend pumps. Diabetes Technol Ther 13(7):695–698CrossRef
40.
Zurück zum Zitat Reifman J, Rajaraman S, Gribok A, Ward WK (2007) Predictive monitoring for improved management of glucose levels. J Diabetes Sci Technol 1(4):478–486CrossRef Reifman J, Rajaraman S, Gribok A, Ward WK (2007) Predictive monitoring for improved management of glucose levels. J Diabetes Sci Technol 1(4):478–486CrossRef
41.
Zurück zum Zitat Sovik O, Thordarson H (1999) Dead-in-bed syndrome in young diabetic patients. Diabetes Care 22(Suppl 2):B40–B42 Sovik O, Thordarson H (1999) Dead-in-bed syndrome in young diabetic patients. Diabetes Care 22(Suppl 2):B40–B42
42.
Zurück zum Zitat Sparacino G, Zanderigo F, Corazza S, Maran A, Facchinetti A, Cobelli C (2007) Glucose concentration can be predicted ahead in time from continuous glucose monitoring sensor time series. IEEE Trans Biomed Eng 54(5):931–937CrossRef Sparacino G, Zanderigo F, Corazza S, Maran A, Facchinetti A, Cobelli C (2007) Glucose concentration can be predicted ahead in time from continuous glucose monitoring sensor time series. IEEE Trans Biomed Eng 54(5):931–937CrossRef
43.
Zurück zum Zitat Sparacino G, Facchinetti A, Maran A, Cobelli C (2008) Continuous glucose monitoring time series and hypo/hyperglycemia prevention: requirements, methods, open problems. Curr Diab Rev 4(3):181–192CrossRef Sparacino G, Facchinetti A, Maran A, Cobelli C (2008) Continuous glucose monitoring time series and hypo/hyperglycemia prevention: requirements, methods, open problems. Curr Diab Rev 4(3):181–192CrossRef
44.
Zurück zum Zitat Stengel RF (1994) Optimal control and estimation. Dover, New York Stengel RF (1994) Optimal control and estimation. Dover, New York
45.
Zurück zum Zitat Walsh J, Roberts R, Bailey T (2010) Guidelines for insulin dosing in continuous subcutaneous insulin infusion using new formulas from a retrospective study of individuals with optimal glucose levels. J Diabetes Sci Technol 4(5):1174–1181CrossRef Walsh J, Roberts R, Bailey T (2010) Guidelines for insulin dosing in continuous subcutaneous insulin infusion using new formulas from a retrospective study of individuals with optimal glucose levels. J Diabetes Sci Technol 4(5):1174–1181CrossRef
46.
Zurück zum Zitat Zecchin C, Facchinetti A, Sparacino G, Cobelli C (2013) Reduction of number and duration of hypoglycemic events by glucose prediction methods: a proof-of-concept in silico study. Diabetes Technol Ther 15(1):66–77CrossRef Zecchin C, Facchinetti A, Sparacino G, Cobelli C (2013) Reduction of number and duration of hypoglycemic events by glucose prediction methods: a proof-of-concept in silico study. Diabetes Technol Ther 15(1):66–77CrossRef
47.
Zurück zum Zitat Zhao C, Dassau E, Jovanovic L, Zisser HC, Doyle JC III, Seborg DE (2012) Predicting subcutaneous glucose concentration using a latent-variable-based statistical method for type 1 diabetes mellitus. J Diabetes Sci Technol 6(3):617–633CrossRef Zhao C, Dassau E, Jovanovic L, Zisser HC, Doyle JC III, Seborg DE (2012) Predicting subcutaneous glucose concentration using a latent-variable-based statistical method for type 1 diabetes mellitus. J Diabetes Sci Technol 6(3):617–633CrossRef
Metadaten
Titel
Hypoglycemia Prevention Using Low Glucose Suspend Systems
verfasst von
B. Wayne Bequette
Copyright-Jahr
2014
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-54464-4_3

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