Skip to main content

2019 | OriginalPaper | Buchkapitel

Improving Prostate Cancer Detection with Breast Histopathology Images

verfasst von : Umair Akhtar Hasan Khan, Carolin Stürenberg, Oguzhan Gencoglu, Kevin Sandeman, Timo Heikkinen, Antti Rannikko, Tuomas Mirtti

Erschienen in: Digital Pathology

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Deep neural networks have introduced significant advancements in the field of machine learning-based analysis of digital pathology images including prostate tissue images. With the help of transfer learning, classification and segmentation performance of neural network models have been further increased. However, due to the absence of large, extensively annotated, publicly available prostate histopathology datasets, several previous studies employ datasets from well-studied computer vision tasks such as ImageNet dataset. In this work, we propose a transfer learning scheme from breast histopathology images to improve prostate cancer detection performance. We validate our approach on annotated prostate whole slide images by using a publicly available breast histopathology dataset as pre-training. We show that the proposed cross-cancer approach outperforms transfer learning from ImageNet dataset.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Arvaniti, E., Claassen, M.: Coupling weak and strong supervision for classification of prostate cancer histopathology images. arXiv preprint arXiv:1811.07013 (2018) Arvaniti, E., Claassen, M.: Coupling weak and strong supervision for classification of prostate cancer histopathology images. arXiv preprint arXiv:​1811.​07013 (2018)
2.
Zurück zum Zitat Arvaniti, E., et al.: Automated gleason grading of prostate cancer tissue microarrays via deep learning. bioRxiv p. 280024 (2018) Arvaniti, E., et al.: Automated gleason grading of prostate cancer tissue microarrays via deep learning. bioRxiv p. 280024 (2018)
3.
Zurück zum Zitat Bejnordi, B.E., et al.: Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer. JAMA 318(22), 2199–2210 (2017)CrossRef Bejnordi, B.E., et al.: Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer. JAMA 318(22), 2199–2210 (2017)CrossRef
4.
Zurück zum Zitat Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A.: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer J. Clin. 68(6), 394–424 (2018) Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A.: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer J. Clin. 68(6), 394–424 (2018)
5.
Zurück zum Zitat Campanella, G., Silva, V.W.K., Fuchs, T.J.: Terabyte-scale deep multiple instance learning for classification and localization in pathology. arXiv preprint arXiv:1805.06983 (2018) Campanella, G., Silva, V.W.K., Fuchs, T.J.: Terabyte-scale deep multiple instance learning for classification and localization in pathology. arXiv preprint arXiv:​1805.​06983 (2018)
6.
Zurück zum Zitat Deng, J., Dong, W., Socher, R., Li, L.J., Li, K., Fei-Fei, L.: ImageNet: a large-scale hierarchical image database. In: IEEE Conference on 2009 Computer Vision and Pattern Recognition, CVPR 2009, pp. 248–255. IEEE (2009) Deng, J., Dong, W., Socher, R., Li, L.J., Li, K., Fei-Fei, L.: ImageNet: a large-scale hierarchical image database. In: IEEE Conference on 2009 Computer Vision and Pattern Recognition, CVPR 2009, pp. 248–255. IEEE (2009)
7.
Zurück zum Zitat He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. corr, vol. abs/1512.03385 (2015) He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. corr, vol. abs/1512.03385 (2015)
8.
Zurück zum Zitat Howard, A.G., et al.: MobileNets: efficient convolutional neural networks for mobile vision applications. arXiv preprint arXiv:1704.04861 (2017) Howard, A.G., et al.: MobileNets: efficient convolutional neural networks for mobile vision applications. arXiv preprint arXiv:​1704.​04861 (2017)
9.
Zurück zum Zitat Hu, Z., Tang, J., Wang, Z., Zhang, K., Zhang, L., Sun, Q.: Deep learning forimage-based cancer detection and diagnosis-a survey. Pattern Recogn. 83, 134–149 (2018)CrossRef Hu, Z., Tang, J., Wang, Z., Zhang, K., Zhang, L., Sun, Q.: Deep learning forimage-based cancer detection and diagnosis-a survey. Pattern Recogn. 83, 134–149 (2018)CrossRef
10.
Zurück zum Zitat Huang, G., Liu, Z., Van Der Maaten, L., Weinberger, K.Q.: Densely connected convolutional networks. In: 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 2261–2269. IEEE (2017) Huang, G., Liu, Z., Van Der Maaten, L., Weinberger, K.Q.: Densely connected convolutional networks. In: 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 2261–2269. IEEE (2017)
11.
Zurück zum Zitat Isaksson, J., Arvidsson, I., Åaström, K., Heyden, A.: Semantic segmentation of microscopic images of H&E stained prostatic tissue using CNN. In: 2017 International Joint Conference on Neural Networks (IJCNN), pp. 1252–1256. IEEE (2017) Isaksson, J., Arvidsson, I., Åaström, K., Heyden, A.: Semantic segmentation of microscopic images of H&E stained prostatic tissue using CNN. In: 2017 International Joint Conference on Neural Networks (IJCNN), pp. 1252–1256. IEEE (2017)
12.
Zurück zum Zitat Källén, H., Molin, J., Heyden, A., Lundström, C., Åström, K.: Towards grading gleason score using generically trained deep convolutional neural networks. In: 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI), pp. 1163–1167. IEEE (2016) Källén, H., Molin, J., Heyden, A., Lundström, C., Åström, K.: Towards grading gleason score using generically trained deep convolutional neural networks. In: 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI), pp. 1163–1167. IEEE (2016)
13.
Zurück zum Zitat Kieffer, B., Babaie, M., Kalra, S., Tizhoosh, H.R.: Convolutional neural networks for histopathology image classification: training vs. using pre-trained networks. In: 2017 Seventh International Conference on Image Processing Theory, Tools and Applications (IPTA), pp. 1–6. IEEE (2017) Kieffer, B., Babaie, M., Kalra, S., Tizhoosh, H.R.: Convolutional neural networks for histopathology image classification: training vs. using pre-trained networks. In: 2017 Seventh International Conference on Image Processing Theory, Tools and Applications (IPTA), pp. 1–6. IEEE (2017)
14.
Zurück zum Zitat Krizhevsky, A., Sutskever, I., Hinton, G.E.: ImageNet classification with deep convolutional neural networks. In: Advances in Neural Information Processing Systems, pp. 1097–1105 (2012) Krizhevsky, A., Sutskever, I., Hinton, G.E.: ImageNet classification with deep convolutional neural networks. In: Advances in Neural Information Processing Systems, pp. 1097–1105 (2012)
15.
Zurück zum Zitat Madabhushi, A., Lee, G.: Image analysis and machine learning in digital pathology: challenges and opportunities (2016)CrossRef Madabhushi, A., Lee, G.: Image analysis and machine learning in digital pathology: challenges and opportunities (2016)CrossRef
16.
Zurück zum Zitat Mehra, R., et al.: Breast cancer histology images classification: training from scratch or transfer learning? ICT Express 4(4), 247–254 (2018)CrossRef Mehra, R., et al.: Breast cancer histology images classification: training from scratch or transfer learning? ICT Express 4(4), 247–254 (2018)CrossRef
17.
Zurück zum Zitat Mormont, R., Geurts, P., Marée, R.: Comparison of deep transfer learning strategies for digital pathology. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition Workshops, pp. 2262–2271 (2018) Mormont, R., Geurts, P., Marée, R.: Comparison of deep transfer learning strategies for digital pathology. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition Workshops, pp. 2262–2271 (2018)
18.
Zurück zum Zitat Nagpal, K., et al.: Development and validation of a deep learning algorithm for improving gleason scoring of prostate cancer. arXiv preprint arXiv:1811.06497 (2018) Nagpal, K., et al.: Development and validation of a deep learning algorithm for improving gleason scoring of prostate cancer. arXiv preprint arXiv:​1811.​06497 (2018)
19.
Zurück zum Zitat Ozkan, T.A., Eruyar, A.T., Cebeci, O.O., Memik, O., Ozcan, L., Kuskonmaz, I.: Interobserver variability in gleason histological grading of prostate cancer. Scand. J. Urol. 50(6), 420–424 (2016)CrossRef Ozkan, T.A., Eruyar, A.T., Cebeci, O.O., Memik, O., Ozcan, L., Kuskonmaz, I.: Interobserver variability in gleason histological grading of prostate cancer. Scand. J. Urol. 50(6), 420–424 (2016)CrossRef
21.
Zurück zum Zitat Schaumberg, A.J., Rubin, M.A., Fuchs, T.J.: H&E-stained whole slide image deep learning predicts SPOP mutation state in prostate cancer. BioRxiv p. 064279 (2018) Schaumberg, A.J., Rubin, M.A., Fuchs, T.J.: H&E-stained whole slide image deep learning predicts SPOP mutation state in prostate cancer. BioRxiv p. 064279 (2018)
22.
Zurück zum Zitat Sermanet, P., Eigen, D., Zhang, X., Mathieu, M., Fergus, R., LeCun, Y.: Overfeat: integrated recognition, localization and detection using convolutional networks. arXiv preprint arXiv:1312.6229 (2013) Sermanet, P., Eigen, D., Zhang, X., Mathieu, M., Fergus, R., LeCun, Y.: Overfeat: integrated recognition, localization and detection using convolutional networks. arXiv preprint arXiv:​1312.​6229 (2013)
23.
Zurück zum Zitat Siegel, R.L., Miller, K.D., Jemal, A.: Cancer statistics, 2017. CA: A Cancer J. Clin. 67(1), 7–30 (2017) Siegel, R.L., Miller, K.D., Jemal, A.: Cancer statistics, 2017. CA: A Cancer J. Clin. 67(1), 7–30 (2017)
24.
Zurück zum Zitat Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014) Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:​1409.​1556 (2014)
25.
Zurück zum Zitat Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J., Wojna, Z.: Rethinking the inception architecture for computer vision. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2818–2826 (2016) Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J., Wojna, Z.: Rethinking the inception architecture for computer vision. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2818–2826 (2016)
Metadaten
Titel
Improving Prostate Cancer Detection with Breast Histopathology Images
verfasst von
Umair Akhtar Hasan Khan
Carolin Stürenberg
Oguzhan Gencoglu
Kevin Sandeman
Timo Heikkinen
Antti Rannikko
Tuomas Mirtti
Copyright-Jahr
2019
DOI
https://doi.org/10.1007/978-3-030-23937-4_11