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Induced Cell Turnover is a recently-described novel therapeutic modality within regenerative medicine consisting of the quantitative and qualitative coordination of targeted endogenous cell ablation with exogenous, patient-specific human pluripotent stem cell-derived exogenous cell administration performed in a gradual, multi-phasic manner so as to extrinsically mediate turnover and replacement of whole tissues and organs at the cellular level, with several features that distinguish it as a novel approach in regenerative medicine distinct from normative cell therapies and tissue/organ engineering. In this chapter we give an overview of the history and current state of regenerative medicine today and analyze the features that distinguish it as a novel paradigm of disease treatment that is methodologically and ontologically distinct from historical medical paradigms. Subsequently, we give an overview of ICT and the specific features that distinguish it as a novel therapeutic modality within regenerative medicine, distinct from normative cell therapies and tissue/organ engineering, and analyze its potential therapeutic efficacy in the context of the current advantages and limitations of normative cell therapies and tissue/organ engineering. Lastly, we explore the bright future of regenerative medicine as a field and an industry, and highlight the potential impact that ICT could come to have upon the field in the years to come.
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- Induced Cell Turnover and the Future of Regenerative Medicine
Francesco Albert Bosco Cortese
- Chapter 23
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