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2019 | OriginalPaper | Buchkapitel

23. Induced Cell Turnover and the Future of Regenerative Medicine

verfasst von : Jakub Stefaniak, Francesco Albert Bosco Cortese, Giovanni Santostasi

Erschienen in: The Transhumanism Handbook

Verlag: Springer International Publishing

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Abstract

Induced Cell Turnover is a recently-described novel therapeutic modality within regenerative medicine consisting of the quantitative and qualitative coordination of targeted endogenous cell ablation with exogenous, patient-specific human pluripotent stem cell-derived exogenous cell administration performed in a gradual, multi-phasic manner so as to extrinsically mediate turnover and replacement of whole tissues and organs at the cellular level, with several features that distinguish it as a novel approach in regenerative medicine distinct from normative cell therapies and tissue/organ engineering. In this chapter we give an overview of the history and current state of regenerative medicine today and analyze the features that distinguish it as a novel paradigm of disease treatment that is methodologically and ontologically distinct from historical medical paradigms. Subsequently, we give an overview of ICT and the specific features that distinguish it as a novel therapeutic modality within regenerative medicine, distinct from normative cell therapies and tissue/organ engineering, and analyze its potential therapeutic efficacy in the context of the current advantages and limitations of normative cell therapies and tissue/organ engineering. Lastly, we explore the bright future of regenerative medicine as a field and an industry, and highlight the potential impact that ICT could come to have upon the field in the years to come.

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Vorheriges Kapitel Harnessing Nature’s Clues for Regeneration, Disease Reversion, and Rejuvenation

Nächstes Kapitel Extending Healthy Human Lifespan Using Gene Therapy

Mao, A. S. & Mooney, D. J. Regenerative medicine: Current therapies and future directions. https://doi.org/10.1073/pnas.1508520112

Chen, F.-M., Zhao, Y.-M., Jin, Y. & Shi, S. Prospects for translational regenerative medicine. Biotechnol. Adv. 30, 658–672 (2012).

Mahla, R. S. & Singh, R. Stem Cells Applications in Regenerative Medicine and Disease Therapeutics. Int. J. Cell Biol. 2016, 1–24 (2016).

Xu, Y., Shi, Y. & Ding, S. A chemical approach to stem-cell biology and regenerative medicine. Nature (2008). https://doi.org/10.1038/nature07042

Bajaj, P., Schweller, R. M., Khademhosseini, A., West, J. L. & Bashir, R. 3D Biofabrication Strategies for Tissue Engineering and Regenerative Medicine. Annu. Rev. Biomed. Eng. 16, 247–276 (2014).

Godwin, J. W. & Rosenthal, N. Scar-free wound healing and regeneration in amphibians: Immunological influences on regenerative success. Differentiation 87, 66–75 (2014).

Price, J. & Allen, S. Exploring the mechanisms regulating regeneration of deer antlers. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 359, 809–22 (2004).

Muneoka, K., Allan, C. H., Yang, X., Lee, J. & Han, M. Mammalian regeneration and regenerative medicine. Birth Defects Res. Part C Embryo Today Rev. 84, 265–280 (2008).

Whited, J. L. & Tabin, C. J. Regeneration review reprise. J. Biol. 9, 15 (2010).

10.

Sampogna, G., Guraya, S. Y. & Forgione, A. Regenerative medicine: Historical roots and potential strategies in modern medicine. J. Microsc. Ultrastruct. 3, 101–107 (2015).

11.

Lagasse, E., Shizuru, J. A., Uchida, N., Tsukamoto, A. & Weissman, I. L. Toward regenerative medicine. Immunity 14, 425–36 (2001).

12.

Swijnenburg, R.-J. et al. Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.

13.

Wright, S. Human Embryonic Stem-Cell Research: Science and Ethics. Am. Sci. 87, 352 (1999).

14.

Takahashi, K. & Yamanaka, S. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell 126, 663–676 (2006).

15.

Lo, B. & Parham, L. Ethical issues in stem cell research. Endocr. Rev. 30, 204–13 (2009).

16.

Ben-David, U. & Benvenisty, N. The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat. Rev. Cancer 11, 268–277 (2011).

17.

Baghaban Eslaminejad, M. & Jahangir, S. Amniotic fluid stem cells and their application in cell-based tissue regeneration. Int. J. Fertil. Steril. 6, 147–56 (2012).

18.

Friedmann, T. & Roblin, R. Gene Therapy for Human Genetic Disease? Science (80–.). 175, (1972).

19.

Miller, A. D. Human gene therapy comes of age. Nature 357, 455–460 (1992).

20.

Krueger, G. G. Fibroblasts and Dermal Gene Therapy: A Minireview. Hum. Gene Ther. 11, 2289–2296 (2000).

21.

Bleiziffer, O., Eriksson, E., Yao, F., Horch, R. E. & Kneser, U. Gene transfer strategies in tissue engineering. J. Cell. Mol. Med. 11, 206–223 (2007).

22.

Andree, C. et al. In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc. Natl. Acad. Sci. U. S. A. 91, 12188–92 (1994).

23.

Eming, S. A. et al. Particle-Mediated Gene Transfer of PDGF Isoforms Promotes Wound Repair. J. Invest. Dermatol. 112, 297–302 (1999).

24.

Mulder, G. et al. Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GAM501): Results of a Phase 1/2 trial. Wound Repair Regen. 17, 772–779 (2009).

25.

Bush, J. et al. Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring. Dermatol. Res. Pract. 2010, 1–6 (2010).

26.

Nixon, A. J. et al. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther. 12, 177–186 (2005).

27.

Edwards, P. C. et al. Sonic hedgehog gene-enhanced tissue engineering for bone regeneration. Gene Ther. 12, 75–86 (2005).

28.

Wang, H., La Russa, M. & Qi, L. S. CRISPR/Cas9 in Genome Editing and Beyond. Annu. Rev. Biochem. 85, 227–264 (2016).

29.

Grobarczyk, B., Franco, B., Hanon, K. & Malgrange, B. Generation of Isogenic Human iPS Cell Line Precisely Corrected by Genome Editing Using the CRISPR/Cas9 System. Stem Cell Rev. Reports 11, 774–787 (2015).

30.

KHATIWALA, C., LAW, R., SHEPHERD, B., DORFMAN, S. & CSETE, M. 3D CELL BIOPRINTING FOR REGENERATIVE MEDICINE RESEARCH AND THERAPIES. Gene Ther. Regul. 7, 1230004 (2012).

31.

Murphy, S. V & Atala, A. 3D bioprinting of tissues and organs. Nat. Biotechnol. 32, 773–785 (2014).

32.

Rhee, S., Puetzer, J. L., Mason, B. N., Reinhart-King, C. A. & Bonassar, L. J. 3D Bioprinting of Spatially Heterogeneous Collagen Constructs for Cartilage Tissue Engineering. ACS Biomater. Sci. Eng. 2, 1800–1805 (2016).

33.

Roseti, L. et al. Scaffolds for Bone Tissue Engineering: State of the art and new perspectives. Mater. Sci. Eng. C 78, 1246–1262 (2017).

34.

Embree, M. C. et al. Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury. Nat. Commun. 7, 13073 (2016).

35.

Chen, K. G., Mallon, B. S., McKay, R. D. G. & Robey, P. G. Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics. Cell Stem Cell 14, 13–26 (2014).

36.

Olmer, R. et al. Suspension culture of human pluripotent stem cells in controlled, stirred bioreactors. Tissue Eng. Part C. Methods 18, 772–84 (2012).

37.

Ikeda, K., Nagata, S., Okitsu, T. & Takeuchi, S. Cell fiber-based three-dimensional culture system for highly efficient expansion of human induced pluripotent stem cells. Sci. Rep. 7, 2850 (2017).

38.

Ekser, B., Rigotti, P., Gridelli, B. & Cooper, D. K. C. Xenotransplantation of solid organs in the pig-to-primate model. Transpl. Immunol. 21, 87–92 (2009).

39.

Yamaguchi, T. et al. Interspecies organogenesis generates autologous functional islets. Nature 542, 191–196 (2017).

40.

Hikabe, O. et al. Reconstitution in vitro of the entire cycle of the mouse female germ line. Nature (2016). https://doi.org/10.1038/nature20104

41.

Kristensen, M. Major foot trauma: the dilemma of reconstruction versus amputation. Clin. Podiatr. Med. Surg. 14, 603–12 (1997).

42.

Harris, A. M., Althausen, P. L., Kellam, J., Bosse, M. J. & Castillo, R. Complications Following Limb-Threatening Lower Extremity Trauma. J. Orthop. Trauma 23, 1–6 (2009).

43.

Penn-Barwell, J. G. Outcomes in lower limb amputation following trauma: A systematic review and meta-analysis. Injury 42, 1474–1479 (2011).

44.

Marshall, C. & Stansby, G. Amputation and rehabilitation. Surg. 31, 236–239 (2013).

45.

Section 2: Limb Salvage and Amputation After Major Lower Limb Trauma. J. Orthop. Trauma 31, S39 (2017).

46.

Simkin, J., Han, M., Yu, L., Yan, M. & Muneoka, K. The Mouse Digit Tip: From Wound Healing to Regeneration. in Methods in molecular biology (Clifton, N.J.) 1037, 419–435 (2013).

47.

Han, M., Yang, X., Lee, J., Allan, C. H. & Muneoka, K. Development and regeneration of the neonatal digit tip in mice. Dev. Biol. 315, 125–135 (2008).

48.

Yu, L. et al. BMP signaling induces digit regeneration in neonatal mice. Development 137, 551–9 (2010).

49.

Yu, L., Han, M., Yan, M., Lee, J. & Muneoka, K. BMP2 induces segment-specific skeletal regeneration from digit and limb amputations by establishing a new endochondral ossification center. Dev. Biol. 372, 263–273 (2012).

50.

Masaki, H. & Ide, H. Regeneration potency of mouse limbs. Dev. Growth Differ. 49, 89–98 (2007).

51.

Leppik, L. P. et al. Effects of electrical stimulation on rat limb regeneration, a new look at an old model. Sci. Rep. 5, 18353 (2016).

52.

Haubner, B. J. et al. Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction. Circ. Res. (2015).

53.

Cortese, F. A. B. & Santostasi, G. Whole-Body Induced Cell Turnover: A Proposed Intervention for Age-Related Damage and Associated Pathology. Rejuvenation Res. 19, 322–336 (2016).

54.

Shay, J. W. & Wright, W. E. Hayflick, his limit, and cellular ageing. Nat. Rev. Mol. Cell Biol. 1, 72–76 (2000).

55.

Shawi, M. & Autexier, C. Telomerase, senescence and ageing. Mech. Ageing Dev. 129, 3–10 (2008).

56.

Hoeijmakers, J. H. J. DNA Damage, Aging, and Cancer. N. Engl. J. Med. 361, 1475–1485 (2009).

57.

Best, B. P. Nuclear DNA Damage as a Direct Cause of Aging. Rejuvenation Res. 12, 199–208 (2009).

58.

Park, C. B. & Larsson, N.-G. Mitochondrial DNA mutations in disease and aging. J. Cell Biol. 193, 809–18 (2011).

59.

Shigenaga, M. K., Hagen, T. M. & Ames, B. N. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. 91, 10771–10778 (1994).

60.

Stadtman, E. Protein oxidation and aging. Science (80–.). 257, (1992).

61.

Squier, T. C. Oxidative stress and protein aggregation during biological aging. Exp. Gerontol. 36, 1539–50 (2001).

62.

Wagner, K.-H., Cameron-Smith, D., Wessner, B. & Franzke, B. Biomarkers of Aging: From Function to Molecular Biology. Nutrients 8, 338 (2016).

63.

Belsky, D. W. et al. Quantification of biological aging in young adults. Proc. Natl. Acad. Sci. 112, E4104–E4110 (2015).

64.

Takahashi, K. et al. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell 131, 861–872 (2007).

65.

Wang, F. et al. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Res. 22, 757–768 (2012).

66.

Luo, L. Z. et al. DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. PLoS One 7, e30541 (2012).

67.

Lin, B., Gupta, D. & Heinen, C. D. Human Pluripotent Stem Cells Have a Novel Mismatch Repair-dependent Damage Response. J. Biol. Chem. 289, 24314–24324 (2014).

68.

Suhr, S. T. et al. Mitochondrial Rejuvenation After Induced Pluripotency. PLoS One 5, e14095 (2010).

69.

Prigione, A., Fauler, B., Lurz, R., Lehrach, H. & Adjaye, J. The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells. Stem Cells 28, 721–733 (2010).

70.

Potter, N. E. et al. Single-cell mutational profiling and clonal phylogeny in cancer. Genome Res. 23, 2115–2125 (2013).

71.

Wagner, A., Regev, A. & Yosef, N. Revealing the vectors of cellular identity with single-cell genomics. Nat. Biotechnol. 34, 1145–1160 (2016).

72.

Pellettieri, J. & Alvarado, A. S. Cell Turnover and Adult Tissue Homeostasis: From Humans to Planarians. Annu. Rev. Genet. 41, 83–105 (2007).

73.

Neves, J., Demaria, M., Campisi, J. & Jasper, H. Of Flies, Mice, and Men: Evolutionarily Conserved Tissue Damage Responses and Aging. Dev. Cell 32, 9–18 (2015).

74.

Loi, P., Iuso, D., Czernik, M. & Ogura, A. A New, Dynamic Era for Somatic Cell Nuclear Transfer? Trends Biotechnol. 34, 791–797 (2016).

75.

Qi, S. D., Smith, P. D. & Choong, P. F. Nuclear reprogramming and induced pluripotent stem cells: a review for surgeons. ANZ J. Surg. 84, 417–423 (2014).

76.

Cherry, A. B. C. & Daley, G. Q. Reprogramming Cellular Identity for Regenerative Medicine. Cell 148, 1110–1122 (2012).

77.

Bianconi, E. et al. An estimation of the number of cells in the human body. Ann. Hum. Biol. 40, 463–471 (2013).

78.

Gelinsky, M., Bernhardt, A. & Milan, F. Bioreactors in tissue engineering: Advances in stem cell culture and three-dimensional tissue constructs. Eng. Life Sci. 15, 670–677 (2015).

79.

Weissbein, U., Benvenisty, N. & Ben-David, U. Genome maintenance in pluripotent stem cells. J. Cell Biol. 204, (2014).

80.

Ghosh, Z. et al. Dissecting the Oncogenic and Tumorigenic Potential of Differentiated Human Induced Pluripotent Stem Cells and Human Embryonic Stem Cells. Cancer Res. 71, 5030–5039 (2011).

81.

Grégoire, D. & Kmita, M. Genetic Cell Ablation. in Methods in molecular biology (Clifton, N.J.) 1092, 421–436 (2014).

82.

MacCorkle, R. A., Freeman, K. W. & Spencer, D. M. Synthetic activation of caspases: artificial death switches. Proc. Natl. Acad. Sci. U. S. A. 95, 3655–60 (1998).

83.

Dougherty, T. J. et al. Photodynamic therapy. J. Natl. Cancer Inst. 90, 889–905 (1998).

84.

Chennat, J., Mino-Kenudson, M., Sahani, D. V. & et al., Current status of endoscopic ultrasound guided ablation techniques. Gastroenterology 140, 1403–9 (2011).

85.

Tiwari, G. et al. Drug delivery systems: An updated review. Int. J. Pharm. Investig. 2, 2–11 (2012).

86.

Edinger, A. L. & Thompson, C. B. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol. 16, 663–669 (2004).

87.

Karjoo, Z., Chen, X. & Hatefi, A. Progress and problems with the use of suicide genes for targeted cancer therapy. Adv. Drug Deliv. Rev. 99, 113–128 (2016).

88.

Trounson, A. & DeWitt, N. D. Pluripotent stem cells progressing to the clinic. Nat. Rev. Mol. Cell Biol. 17, 194–200 (2016).

89.

Niccoli, T. & Partridge, L. Ageing as a Risk Factor for Disease. Curr. Biol. 22, R741–R752 (2012).

Titel: Induced Cell Turnover and the Future of Regenerative Medicine
verfasst von: Jakub Stefaniak
Francesco Albert Bosco Cortese
Giovanni Santostasi
Verlag: Springer International Publishing
Buch: The Transhumanism Handbook
Print ISBN: 978-3-030-16919-0

Electronic ISBN: 978-3-030-16920-6

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-3-030-16920-6_23

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