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Erschienen in:
2006 | OriginalPaper | Buchkapitel
Visualization of Functional Aspects of microRNA Regulatory Networks Using the Gene Ontology
verfasst von : Alkiviadis Symeonidis, Ioannis G. Tollis, Martin Reczko
Erschienen in: Biological and Medical Data Analysis
Verlag: Springer Berlin Heidelberg
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The post-transcriptional regulation of genes by microRNAs (miRNAs) is a recently discovered mechanism of growing importance. To uncover functional relations between genes regulated by the same miRNA or groups of miRNAs we suggest the simultaneous visualization of the miRNA regulatory network and the Gene Ontology (GO) categories of the targeted genes. The miRNA regulatory network is shown using circular drawings and the GO is visualized using treemaps. The GO categories of the genes targeted by user-selected miRNAs are highlighted in the treemap showing the complete GO hierarchy or selected branches of it. With this visualization method patterns of reoccurring categories can easily identified supporting the discovery of the functional role of miRNAs. Executables for MS-Windows are available under
www.ics.forth.gr/~reczko/isbmda06