nach oben

Journal of Computational Neuroscience

Erschienen in:

01.06.2012

Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study

verfasst von: Rosa Q. So, Alexander R. Kent, Warren M. Grill

Erschienen in: Journal of Computational Neuroscience | Ausgabe 3/2012

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Deep brain stimulation (DBS) and lesioning are two surgical techniques used in the treatment of advanced Parkinson’s disease (PD) in patients whose symptoms are not well controlled by drugs, or who experience dyskinesias as a side effect of medications. Although these treatments have been widely practiced, the mechanisms behind DBS and lesioning are still not well understood. The subthalamic nucleus (STN) and globus pallidus pars interna (GPi) are two common targets for both DBS and lesioning. Previous studies have indicated that DBS not only affects local cells within the target, but also passing axons within neighboring regions. Using a computational model of the basal ganglia-thalamic network, we studied the relative contributions of activation and silencing of local cells (LCs) and fibers of passage (FOPs) to changes in the accuracy of information transmission through the thalamus (thalamic fidelity), which is correlated with the effectiveness of DBS. Activation of both LCs and FOPs during STN and GPi-DBS were beneficial to the outcome of stimulation. During STN and GPi lesioning, effects of silencing LCs and FOPs were different between the two types of lesioning. For STN lesioning, silencing GPi FOPs mainly contributed to its effectiveness, while silencing only STN LCs did not improve thalamic fidelity. In contrast, silencing both GPi LCs and GPe FOPs during GPi lesioning contributed to improvements in thalamic fidelity. Thus, two distinct mechanisms produced comparable improvements in thalamic function: driving the output of the basal ganglia to produce tonic inhibition and silencing the output of the basal ganglia to produce tonic disinhibition. These results show the importance of considering effects of activating or silencing fibers passing close to the nucleus when deciding upon a target location for DBS or lesioning.

Vorheriger Artikel An L 1-regularized logistic model for detecting short-term neuronal interactions

Nächster Artikel Detecting effective connectivity in networks of coupled neuronal oscillators

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Nur mit Berechtigung zugänglich

Afsharpour, S. (1985). Light microscopic analysis of Golgi-impregnated rat subthalamic neurons. Journal of Computational Neurology, 236(1), 1–13.CrossRef

Alvarez, L., Macias, R., Pavón, N., López, G., Rodríguez-Oroz, M. C., Rodríguez, R., et al. (2009). Therapeutic efficacy of unilateral subthalamotomy in Parkinson’s disease: results in 89 patients followed for up to 36 months. Journal of Neurology, Neurosurgery, and Psychiatry, 80(9), 979–985.PubMedCrossRef

Aziz, T. Z., Peggs, D., Sambrook, M. A., & Crossman, A. R. (1991). Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. Movement Disorders, 6(4), 288–292.PubMedCrossRef

Baker, K. B., Lee, J. Y., Mavinkurve, G., Russo, G. S., Walter, B., DeLong, M. R., et al. (2010). Somatotopic organization in the internal segment of the globus pallidus in Parkinson’s disease. Experimental Neurology, 2, 219–225.CrossRef

Bejjani, B., Damier, P., Arnulf, I., Bonnet, A. M., Vidailhet, M., Dormont, D., et al. (1997). Pallidal stimulation for Parkinson’s disease: two targets? Neurology, 49, 1564–1569.PubMed

Begman, H., Wichmann, T., & DeLong, M. R. (1990). Reversal of experimental parkinsonism by lesions of the STN. Science, 249, 1436–1438.CrossRef

Bergman, H., Wichmann, T., Karmon, B., & DeLong, M. R. (1994). The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. Journal of Neurophysiology, 72, 507–520.PubMed

Bergman, H., Feingold, A., Nini, A., Raz, A., Slovin, H., Abeles, M., et al. (1998). Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates. Trends in Neuroscience, 21, 32–28.CrossRef

Benazzouz, A., Breit, S., Koudsie, A., Pollak, P., Krack, P., & Benabid, A. L. (2002). Intraoperative microrecordings of the subthalamic nucleus in Parkinson’s disease. Movement Disorders, 17(Suppl 3), S145–S149.PubMedCrossRef

Beurrier, C., Congar, P., Bioulac, B., & Hammond, C. (1999). Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode. Journal of Neuroscience, 19, 599–609.PubMed

Bevan, M. D., & Wilson, C. J. (1999). Mechanisms underlying spontaneous oscillation and rhythmic firing in rat subthalamic neurons. Journal of Neuroscience, 19(17), 7617–7628.PubMed

Birdno, M. J., & Grill, W. M. (2008). Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency. Neurotherapeutics, 5(1), 14–25. Review.PubMedCrossRef

Boraud, T., Bezard, E., Guehl, D., Bioulac, B., & Gross, C. (1998). Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey. Brain Research, 787, 157–160.PubMedCrossRef

Brown, P., Oliviero, A., Mazzone, P., Insola, A., Tonali, P., & Di Lazzaro, V. (2001). Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson’s disease. Journal of Neuroscience, 21, 1033–1038.PubMed

Butson, C. R., Cooper, S. E., Henderson, J. M., Wolgamuth, B., & McIntyre, C. C. (2010). Probabilistic analysis of activation volumes generated during deep brain stimulation. NeuroImage, 54(3), 2096–2104.PubMedCrossRef

Carpenter, M. B., Whittier, J. R., & Mettler, F. A. (1950). Analysis of choreoid hyperkinesia in the Rhesus monkey; surgical and pharmacological analysis of hyperkinesia resulting from lesions in the subthalamic nucleus of Luys. The Journal of Comparative Neurology, 92(3), 293–331.PubMedCrossRef

Chang, J. W., Yang, J. S., Jeon, M. F., Lee, B. H., & Chung, S. S. (2003). Effect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat parkinsonian models with 6-hydroxydopamine. Acta Neurochirurgica. Supplement, 87, 163–168.PubMed

Coban, A., Hanagasi, H. A., Karamursel, S., & Barlas, O. (2009). Comparison of unilateral pallidotomy and subthalamotomy findings in advanced idiopathic Parkinson’s disease. British Journal of Neurosurgery, 23(1), 23–29.PubMedCrossRef

Cooper, A. J., & Stanford, I. M. (2000). Electrophysiological and morphological characteristics of three subtypes of rat globus pallidus neurone in vitro. The Journal of Physiology, 527(Pt 2), 291–304.PubMedCrossRef

Costa, R. M., Lin, S. C., Sotnikova, T. D., Cyr, M., Gainetdinov, R. R., Caron, M. G., et al. (2006). Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron, 52, 359–369.PubMedCrossRef

Destexhe, A., Neubig, M., Ulrich, D., & Huguenard, J. (1998). Dendritic low-threshold calcium currents in thalamic relay cells. Journal of Neuroscience, 18(10), 3574–3588.PubMed

Dorval, A. D., Russo, G. S., Hashimoto, T., Xu, W., Grill, W. M., & Vitek, J. L. (2009). Deep brain stimulation reduces neuronal entropy in the MPTP-primate model of Parkinson’s disease. Journal of Neurophysiology, 100, 2807–2818.CrossRef

Dorval, A. D., Kuncel, A. M., Birdno, M. J., Turner, D. A., & Grill, W. M. (2010). Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity. Journal of Neurophysiology, 801.

Eusebio, A., Chen, C. C., Lu, C. S., Lee, S. T., Tsai, C. H., Limousin, P., et al. (2008). Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson’s disease. Experimental Neurology, 209, 125–130.PubMedCrossRef

Feng, X. J., Shea-Brown, E., Greenwald, B., Kosut, R., & Rabitz, H. (2007). Optimal deep brain stimulation of the subthalamic nucleus–a computational study. Journal of Computational Neuroscience, 23(3), 265–282.PubMedCrossRef

Fogelson, N., Kühn, A. A., Silberstein, P., Limousin, P. D., Hariz, M., Trottenberg, T., et al. (2005). Frequency dependent effects of subthalamic nucleus stimulation in Parkinson’s disease. Neuroscience Letters, 382, 5–9.PubMedCrossRef

Garcia, L., D’Alessandro, G., Fernagut, P. O., Bioulac, B., & Hammond, C. (2005). Impact of high-frequency stimulation parameters on the pattern of discharge of subthalamic neurons. Journal of Neurophysiology, 94, 3662–3669.PubMedCrossRef

Godinho, F., Thobois, S., Magnin, M., Guenot, M., Polo, G., Benatru, I., et al. (2006). Subthalamic nucleus stimulation in Parkinson’s disease: anatomical and electrophysiological localization of active contacts. Journal of Neurology, 253, 1347–1355.PubMedCrossRef

Grill, W. M., Snyder, A. N., & Miocinovic, S. (2004). Deep brain stimulation creates an informational lesion of the stimulated nucleus. Neuroreport, 15, 1137–1140.PubMedCrossRef

Gross, R. E. (2008). What happened to posteroventral pallidotomy for Parkinson’s disease and dystonia? Neurotherapeutics, 5(2), 281–293.PubMedCrossRef

Guo, Y., Rubin, J. E., McIntyre, C. C., Vitek, J. L., & Terman, D. (2008). Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computation model. Journal of Neurophysiology, 99, 1477–1492.PubMedCrossRef

Hahn, P. J., Hashimoto, T., Russo, G. S., Xu, W., Miocinovic, S., Mcintyre, C., et al. (2008). Pallidal burst activity during therapeutic deep brain stimulation. Experimental Neurology, 211, 243–251.PubMedCrossRef

Hahn, P. J., & McIntyre, C. C. (2010). Modeling shifts in the rate and pattern of subthalamopallidal network activity during deep brain stimulation. Journal of Computational Neuroscience, 28, 425–441.PubMedCrossRef

Hallworth, N., Wilson, C., & Bevan, M. (2003). Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat. Journal of Neuroscience, 23, 7525–7542.PubMed

Hamel, W., Fietzek, U., Morsnowski, A., Schrader, B., Herzog, J., Weinert, D., et al. (2003). Deep brain stimulation of the subthalamic nucleus in Parkinson’s disease: evaluation of active electrode contacts. Journal of Neurology, Neurosurgery, and Psychiatry, 74, 1036–1046.PubMedCrossRef

Hashimoto, T., Elder, C. M., Okun, M. S., Patrick, S. K., & Vitek, J. L. (2003). Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons. Journal of Neuroscience, 23, 1916–1923.PubMed

Hassini, O. K., Mouroux, M., & Feger, J. (1996). Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus. Neuroscience, 72, 105–115.CrossRef

Jahnsen, H., & Llinas, R. (1984). Electrophysiological properties of guinea-pig thalamic neurones: an in vitro study. The Journal of Physiology, 349, 205–226.PubMed

Johnsen, E. L., Sunde, N., Mogensen, P. H., & Ostergaard, K. (2010). MRI verified STN stimulation site—gait improvement and clinical outcome. European Journal of Neurology, 17, 746–753.PubMedCrossRef

Johnson, M. D., & McIntyre, C. C. (2008). Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulation. Journal of Neurophysiology, 100, 2549–2563.PubMedCrossRef

Kita, H., & Kitai, S. T. (1991). Intracellular study of rat globus pallidus neurons: membrane properties and responses to neostriatal, subthalamic and nigral stimulation. Brain Research, 564, 296–305.PubMedCrossRef

Kita, H., & Kita, T. (2011). Role of striatum in the pause and burst generation in the globus pallidus of 6-OHDA-treated rats. Frontiers in Systems Neuroscience, 5, 1–11.CrossRef

Kleiner-Fisman, G., Lozano, A., Moro, E., Poon, Y. Y., & Lang, A. E. (2010). Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia. Movment Disorders, 25(10), 1496–1498.CrossRef

Krack, P., Pollak, P., Limousin, P., Hoffmann, D., Benazzouz, A., Le Bas, J. F., et al. (1998). Opposite motor effects of pallidal stimulation in Parkinson’s disease. Annals of Neurology, 43, 180–192.PubMedCrossRef

Kuncel, A. M., & Grill, W. M. (2004) Selection of stimulus parameters for deep brain stimulation. Clinical Neurophysiology, 115(11), 2431–2441.

Levy, R., Hutchison, W. D., Lozano, A. M., & Dostrovsky, J. O. (2000). High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor. Journal of Neuroscience, 20, 7766–7775.PubMed

Levy, R., Ashby, P., Hutchison, W. D., Lang, A. E., Lozano, A. M., & Dostrovsky, J. O. (2002). Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson’s disease. Brain, 125, 1196–1209.PubMedCrossRef

Magill, P. J., Bolam, J. P., & Bevan, M. D. (2001). Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus globus pallidus network. Neuroscience, 106, 313–330.PubMedCrossRef

Magnin, M., Morel, A., & Jeanmonod, D. (2000). Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients. Neuroscience, 96, 549–564.PubMedCrossRef

Mallet, N., Pogosyan, A., Márton, L. F., Bolam, P. B. J., Peter, B., & Magill, P. J. (2008). Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity. Journal of Neuroscience, 28, 14245–14258.PubMedCrossRef

McIntyre, C. C., Grill, W. M., Sherman, D. L., & Thakor, N. V. (2004). Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. Journal of Neurophysiology, 91, 1457–1469.PubMedCrossRef

McIntyre, C. C., & Hahn, P. J. (2009). Network perspectives on the mechanisms of deep brain stimulation. Neurobiology of Disease, 38(3), 329–337.PubMedCrossRef

Miocinovic, S., Parent, M., Butson, C. R., Hahn, P. J., Russo, G. S., Vitek, J. L., et al. (2006). Computational analysis of subthalamic nucleus and lenticular fasciulus activation during therapeutic deep brain stimulation. Journal of Neurophysiology, 96, 1569–1580.PubMedCrossRef

Moro, E., Esselink, R. J., Xie, J., Hommel, M., Benabid, A. L., & Pollak, P. (2002). The impact on Parkinson’s disease of electrical parameter settings in STN stimulation. Neurology, 59, 706–713.PubMed

Moro, E., Lozano, A. M., Pollak, P., Agid, Y., Rehncrona, S., Volkmann, J., et al. (2010). Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson’s disease. Movement Disorders, 25, 578–586.PubMedCrossRef

Montgomery, E. B., Jr. (2005). Effect of subthalamic nucleus stimulation patterns on motor performance in Parkinson’s disease. Parkinsonism & Related Disorders, 11, 167–171.CrossRef

Nambu, A., & Llinas, R. (1994). Electrophysiology of globus pallidus neurons in vitro. Journal of Neurophysiology, 72, 1127–1139.PubMed

Nishio, M., Korematsu, K., Yoshioka, S., Nagai, Y., Maruo, T., Ushio, Y., et al. (2009). Long-term suppression of tremor by deep brain stimulation of the ventral intermediate nucleus of the thalamus combined with pallidotomy in hemiparkinsonian patients. Journal of Clinical Neuroscience, 16(11), 1489–1491.PubMedCrossRef

Obwegeser, A. A., Uitti, R. J., Lucas, J. A., Witte, R. J., Turk, M. F., Galiano, K., et al. (2008). Correlation of outcome to neurosurgical lesions: confirmation of a new method using data after microelectrode-guided pallidotomy. British Journal of Neurosurgery, 22(5), 654–662.PubMedCrossRef

Okun, M. S., & Vitek, J. L. (2004). Lesion therapy for Parkinson’s disease and other movement disorders: update and controversies. Movement Disorders, 19(4), 375–389.PubMedCrossRef

Parent, A., Sato, F., Wu, Y., Gauthier, J., Lévesque, M., & Parent, M. (2000). Organization of the basal ganglia: the importance of axonal collateralization. Trends in Neuroscience, 10(Suppl), S20–S27.CrossRef

Parent, M., Lévesque, M., & Parent, A. (2001). Two types of projection neurons in the internal pallidum of primates: single-axon tracing and three-dimensional reconstruction. The Journal of Comparative Neurology, 439, 162–175.PubMedCrossRef

Parent, M., & Parent, A. (2004). The pallidofugal motor fiber system in primates. Parkinsonism & Related Disorders, 10, 203–211.CrossRef

Patel, N. K., Heywood, P., O’Sullivan, K., McCarter, R., Love, S., & Gill, S. S. (2003). Unilateral subthalamotomy in the treatment of Parkinson’s disease. Brain, 126(Pt 5), 1136–1145.PubMedCrossRef

Pirini, M., Rocchi, L., Sensi, M., & Chiari, L. (2009). A computational modelling approach to investigate different targets in deep brain stimulation for Parkinson’s disease. Journal of Computational Neuroscience, 26(1), 91–107.PubMedCrossRef

Plenz, D., & Kital, S. T. (1999). A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus. Nature, 400, 677–682.PubMedCrossRef

Pollo, C., Vingerhoets, F., Pralong, E., Ghika, J., Maeder, P., Meuli, R., et al. (2007). Localization of electrodes in the subthalamic nucleus on magnetic resonance imaging. Journal of Neurosurgery, 106, 36–44.PubMedCrossRef

Rubin, J. E., & Terman, D. (2004). High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model. Journal of Computational Neuroscience, 16, 211–235.PubMedCrossRef

Sato, F., Lavallée, P., Lévesque, M., & Parent, A. (2000). Single-axon tracing study of neurons of the external segment of the globus pallidus in primate. The Journal of Comparative Neurology, 417, 17–31.PubMedCrossRef

Smith, Y., Bevan, M. D., Shink, E., & Bolam, J. P. (1998). Microcircuitry of the direct and indirect pathways of the basal ganglia. Neuroscience, 86, 353–387.PubMedCrossRef

Stanford, I. M. (2003) Independent Neuronal Oscillators of the Rat Globus Pallidus. Journal of Neurophysiology, 89, 1713–1717.

St George, R. J., Nutt, J. G., Burchiel, K. J., & Horak, F. B. (2010). A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD. Neurology, 75(14), 1292–1299.PubMedCrossRef

Steigerwald, F., Pötter, M., Herzog, J., Pinsker, M., Kopper, F., Mehdorn, H., et al. (2008). Neuronal activity of the human subthalamic nucleus in the parkinsonian and nonparkinsonian state. Journal of Neurophysiology, 100, 2515–2524.PubMedCrossRef

Su, P. C., Tseng, H. M., Liu, H. M., Yen, R. F., & Liou, H. H. (2002). Subthalamotomy for advanced Parkinson disease. Journal of Neurosurgery, 97(3), 598–606.PubMedCrossRef

Tarsy, D. (2009). Does subthalamotomy have a place in the treatment of Parkinson’s disease? Journal of Neurology, Neurosurgery and Psychiatry, 80(9), 939–940.CrossRef

Terman, D., Rubin, J. E., Yew, A. C., & Wilson, C. J. (2002). Activity patterns in a model for the subthalamopallidal network of the basal ganglia. Journal of Neuroscience, 22, 2963–2976.PubMed

Timmermann, L., Wojtecki, L., Gross, J., Lehrke, R., Voges, J., Maarouf, M., et al. (2004). Ten-hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson’s disease. Movement Disorders, 19, 1328–1333.PubMedCrossRef

Voges, J., Volkmann, J., Allert, N., Lehrke, R., Koulousakis, A., Freund, H. J., et al. (2002). Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position. Journal of Neurosurgery, 96, 269–279.PubMedCrossRef

Weaver, F. M., Follett, K., Stern, M., Hur, K., Harris, C., Marks, W. J., Jr., et al. (2009). Bilateral deep brain stimulation vs best medical therapy for patients with advanced parkinson disease: a randomized controlled trial. JAMA, 301, 63–73.PubMedCrossRef

Wilson, C. J., Weyrick, A., Terman, D., Hallworth, N. E., & Bevan, M. D. (2004). A model of reverse spike frequency adaptation and repetitive firing of subthalamic nucleus neurons. Journal of Neurophysiology, 91, 1963–1980.PubMedCrossRef

Wilson, C. L., Cash, D., Galley, K., Chapman, H., Lacey, M. G., & Stanford, I. M. (2006). Subthalamic nucleus neurones in slices from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mice show irregular, dopamine-reversible firing pattern changes, but without synchronous activity. Neuroscience, 143, 565–572.PubMedCrossRef

Wichmann, T., Bergman, H., & DeLong, M. R. (1994). The primate subthalamic nucleus. III. Changes in motor behavior and neuronal activity in the internal pallidum induced by subthalamic inactivation in the MPTP model of parkinsonism. Journal of Neurophysiology, 72, 521–530.PubMed

Wichmann, T., & Soares, J. (2006). Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonism. Journal of Neurophysiology, 95, 2120–2133.PubMedCrossRef

Xu, W., Russo, G. S., Hashimoto, T., Zhang, J., & Vitek, J. L. (2008). Subthalamic nucleus stimulation modulates thalamic neuronal activity. Journal of Neuroscience, 28, 11916–11924.PubMedCrossRef

Yelnik, J., Damier, P., Demeret, S., Gervais, D., Bardinet, E., Bejjani, B. P., et al. (2003). Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method. Journal of Neurosurgery, 99, 89–99.PubMedCrossRef

Yokoyama, T., Ando, N., Sugiyama, K., Akamine, S., & Namba, H. (2006). Relationship of stimulation site location within the subthalamic nucleus region to clinical effects on parkinsonian symptoms. Stereotactic and Functional Neurosurgery, 84(4), 70–175.CrossRef

Zonenshayn, M., Sterio, D., Kelly, P. J., Rezai, A. R., & Beric, A. (2004). Location of the active contact within the subthalamic nucleus (STN) in the treatment of idiopathic Parkinson’s disease. Surgical Neurology, 62, 216–226.PubMedCrossRef

Titel: Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study
verfasst von: Rosa Q. So
Alexander R. Kent
Warren M. Grill
Publikationsdatum: 01.06.2012
Verlag: Springer US
Erschienen in: Journal of Computational Neuroscience / Ausgabe 3/2012
Print ISSN: 0929-5313
Elektronische ISSN: 1573-6873
DOI: https://doi.org/10.1007/s10827-011-0366-4

Springer Professional

Abstract

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Wirtschaft"

Springer Professional "Technik"

Weitere Artikel der Ausgabe 3/2012

The effect of neural adaptation on population coding accuracy

An L 1-regularized logistic model for detecting short-term neuronal interactions

Energy-based stochastic control of neural mass models suggests time-varying effective connectivity in the resting state

Detecting effective connectivity in networks of coupled neuronal oscillators

A model for complex sequence learning and reproduction in neural populations

The faithful copy neuron

Premium Partner