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Journal of Polymer Research

Erschienen in:

01.03.2018 | ORIGINAL PAPER

Biocompatible tumor micro-environment responsive CS-g-PNIPAAm co-polymeric nanoparticles for targeted Oxaliplatin delivery

verfasst von: Archana S. Patil, Anand P. Gadad, Ravindra D. Hiremath, Shrinivas D. Joshi

Erschienen in: Journal of Polymer Research | Ausgabe 3/2018

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Abstract

The objective of the research study was to develop and characterize a biodegradable, thermo and pH dual responsive Oxaliplatin-loaded chitosan-graft-poly-N-isopropylacrylamide (CS-g-PNIPAAm) co-polymeric nanoparticles as a tumor-targeting drug delivery system. CS-g-PNIPAAm co-polymers were synthesized, characterized and optimized its thermo and pH responsive properties for tumor microenvironment conditions. Optimized co-polymer could be efficiently loaded with Oxaliplatin in nanoparticle form, evaluated for their morphology (TEM), particle size, zeta potential, loading efficiency and drug content. In vitro drug release study at tumor microenvironment and physiological pH and temperature conditions. The in vitro drug release was optimal at above lower critical solution temperature (LCST) and tumor microenvironment pH when compared to physiological pH & temperature. MTT assay and fluorescence microscopic study showed that drug release and cell uptake was significantly enhanced in tumor microenvironment. In conclusion, the obtained nanoparticles appeared to be of great promise in tumor targeted drug delivery of oxaliplatin.

Vorheriger Artikel Investigation of the impact response of PMMA-based nano-rubbers under various temperatures

Nächster Artikel Synthesis, characterization and photo – switching properties of azobenzene mesogen containing poly (ether - ester) s from cashew nut shell liquid

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Titel: Biocompatible tumor micro-environment responsive CS-g-PNIPAAm co-polymeric nanoparticles for targeted Oxaliplatin delivery
verfasst von: Archana S. Patil
Anand P. Gadad
Ravindra D. Hiremath
Shrinivas D. Joshi
Publikationsdatum: 01.03.2018
Verlag: Springer Netherlands
Erschienen in: Journal of Polymer Research / Ausgabe 3/2018
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-018-1453-2

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