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Journal of Nanoparticle Research
Erschienen in: Journal of Nanoparticle Research 4/2012

01.03.2012 | Research Paper

Manganese–gold nanoparticles as an MRI positive contrast agent in mesenchymal stem cell labeling

verfasst von: Simona E. Hunyadi Murph, Stephanie Jacobs, Jimei Liu, Tom C.-C. Hu, Matthew Siegfired, Steven M. Serkiz, Joan Hudson

Erschienen in: Journal of Nanoparticle Research | Ausgabe 4/2012

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Abstract

We report a straightforward approach to prepare multifunctional manganese–gold nanoparticles by attaching Mn(II) ions onto the surface of 20 nm citrate-capped gold nanoparticles. In vitro MRI measurements made in agarose gel phantoms exhibited high relaxivity (18.26 ± 1.04 mmol−1 s−1). Controlled incubation of the nanoparticles with mesenchymal stem cells (MSCs) was used to study cellular uptake of these particles and this process appeared to be controlled by the size of the nanoparticle aggregates in the extracellular solution. SEM images of live MSCs showed an increased concentration of particles near the cell membrane and a distribution of the size of particles within the cells. Survivability for MSCs in contact with Mn–Au NPs was greater than 97% over the 3-day period and up to the 1 mM Mn used in this study. The high relaxivity and low cell mortality are suggestive of an enhanced positive contrast agent for in vitro or in vivo applications.
Vorheriger Artikel An alternative flexible electrode for dye-sensitized solar cells
Nächster Artikel Fabrication of silk fibroin nanoparticles for controlled drug delivery

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Metadaten
Titel
Manganese–gold nanoparticles as an MRI positive contrast agent in mesenchymal stem cell labeling
verfasst von
Simona E. Hunyadi Murph
Stephanie Jacobs
Jimei Liu
Tom C.-C. Hu
Matthew Siegfired
Steven M. Serkiz
Joan Hudson
Publikationsdatum
01.03.2012
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 4/2012
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-011-0658-7

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