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Erschienen in:
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2018 | OriginalPaper | Buchkapitel

2. Lipid Molecular-Ion Interaction Study Based on Nanodisc

verfasst von : Dr. Yunchen Bi

Erschienen in: Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies

Verlag: Springer Berlin Heidelberg

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Abstract

Reconstituting the membrane protein into a suitable model membrane is the first and essential step in studying the membrane protein in vitro. Commonly used membrane mimics include detergent micelles, detergent/lipid bicelles, and lipo somes (reviewed in the previous chapter). A newer model system is the “nanodisc,” originally designed by Dr. Sligar [1]. The nanodisc’s properties as a model membrane are discussed at length in this chapter, but in general its defining qualities are that it is a stable membrane mimic with a precisely controlled size and stoichiometry, making it a suitable system to study membrane proteins in their native environments.

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Vorheriges Kapitel Introduction
Nächstes Kapitel Calcium Regulates T Cell Receptor Activation by Modulating Phospholipid Electrostatic Property
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Metadaten
Titel
Lipid Molecular-Ion Interaction Study Based on Nanodisc
verfasst von
Dr. Yunchen Bi
Copyright-Jahr
2018
Verlag
Springer Berlin Heidelberg
Buch
Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies

Print ISBN: 978-3-662-54616-1

Electronic ISBN: 978-3-662-54618-5

Copyright-Jahr: 2018

DOI
https://doi.org/10.1007/978-3-662-54618-5_2

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