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Erschienen in:
2013 | OriginalPaper | Buchkapitel
Manifold Learning Characterization of Abnormal Myocardial Motion Patterns: Application to CRT-Induced Changes
verfasst von : Nicolas Duchateau, Gemma Piella, Adelina Doltra, Lluis Mont, Josep Brugada, Marta Sitges, Bart H. Bijnens, Mathieu De Craene
Erschienen in: Functional Imaging and Modeling of the Heart
Verlag: Springer Berlin Heidelberg
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The present paper aims at quantifying the evolution of a given motion pattern under cardiac resynchronization therapy (CRT). It builds upon techniques for population-based cardiac motion quantification (statistical atlases, for inter-sequence spatiotemporal alignment and the definition of normal/abnormal motion). Manifold learning is used on spatiotemporal maps of myocardial motion abnormalities to represent a given abnormal pattern and to compare any individual to that pattern. The methodology was applied to 2D echocardiographic sequences in a 4-chamber view from 108 subjects (21 healthy volunteers and 87 CRT candidates) at baseline, with pacing ON, and at 12 months follow-up. Experiments confirmed that recovery of a normal motion pattern is a necessary but not sufficient condition for CRT response.