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Journal of Applied and Industrial Mathematics
Erschienen in: Journal of Applied and Industrial Mathematics 2/2020

01.05.2020

Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila

verfasst von: T. A. Bukharina, A. A. Akinshin, V. P. Golubyatnikov, D. P. Furman

Erschienen in: Journal of Applied and Industrial Mathematics | Ausgabe 2/2020

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Abstract

The results are presented of mathematical and computer simulation of the functioning of the central regulatory circuit (CRC) which is the system integrator of the gene networks of morphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented by the complex of Achaete-Scute (AS-C) genes, the main genes of the mechanoreceptor morphogenesis. The content level of the proteins encoded by the AS-C genes is a determining factor for initiating the development of a mechanoreceptor. We carried out a comparative study of the CRC behavior under normal conditions and in the presence of mutational changes in the Achaete-Scute complex. The results of simulation are in good accord with the available biological data.
Vorheriger Artikel Computational Complexity of the Problem of Choosing Typical Representatives in a -Clustering of a Finite Set of Points in a Metric Space
Nächster Artikel On the Angular Moment Operators of Attenuated Ray Transforms of Scalar -Fields

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Metadaten
Titel
Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila
verfasst von
T. A. Bukharina
A. A. Akinshin
V. P. Golubyatnikov
D. P. Furman
Publikationsdatum
01.05.2020
Verlag
Pleiades Publishing
Erschienen in
Journal of Applied and Industrial Mathematics / Ausgabe 2/2020
Print ISSN: 1990-4789
Elektronische ISSN: 1990-4797
DOI
https://doi.org/10.1134/S1990478920020040

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