2011 | OriginalPaper | Buchkapitel
Mutation and Random Genetic Drift
verfasst von : Alison Etheridge
Erschienen in: Some Mathematical Models from Population Genetics
Verlag: Springer Berlin Heidelberg
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Evolution is a random process. Random events enter in many ways, from errors in copying genetic material to small and large scale environmental changes, but the most basic source of randomness that we must understand is due to reproduction in a finite population leading to
random genetic drift
. The simplest model of random genetic drift was developed independently by Sewall Wright and R.A. Fisher and is known as the Wright–Fisher model.We consider a population in which every individual is equally likely to mate with every other and in which all individuals experience the same conditions. Such a population is called
panmictic
.We also suppose that the population is
neutral
(everyone has an equal chance of reproductive success). Most species are either haploid meaning that they have a single copy of each chromosome (for example, most bacteria), or
diploid
meaning that they have two copies of each chromosome (for example, humans). We suppose that the population is haploid, so that each individual has exactly one parent. Although in a diploid population individuals have two parents, each
gene
can be traced to a single parental gene in the previous generation and so it is customary in this setting to model the genes in a diploid population of size
N
as a haploid population of size 2
N
.
1
As we shall see in Sect. 5.6, this device fails once we are interested in tracing several genes at the same time.