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Erschienen in:
Introduction to Nanotechnology Kapitel lesen Erstes Kapitel lesen

2017 | OriginalPaper | Buchkapitel

21. Nano-Particles for Biomedical Applications

verfasst von : Paolo Decuzzi, Alessandro Coclite, Aeju Lee, Anna Lisa Palange, Daniele Di Mascolo, Ciro Chiappini, Hélder A. Santos, Maria Laura Coluccio, Gerardo Perozziello, Patrizio Candeloro, Enzo Di Fabrizio, Francesco Gentile

Erschienen in: Springer Handbook of Nanotechnology

Verlag: Springer Berlin Heidelberg

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Abstract

Nanoparticles (NPs) are extremely small particulates with an average size that ranges from a micron or less to a few nanometers. The large majority of NPs necessitate nanotechnology methods for their production. The size of NPs may vary over a significant range, which underlies their scientific potential in that NPs may help cross the bridge between bulk materials and molecular structures. More importantly, NPs are (nano)tech products and thus, in contrast to natural systems, they can be designed and engineered. On directly interacting with cells, including the structures of cells, their machinery and their waste products, NPs represent an unprecedented tool for addressing specific biological problems. In this chapter, we will briefly review some recent advances in nanoparticle research for biomedical applications, ranging from mesoporous silicon particles to gold and silver nanoparticles and polymeric nanocarriers for therapeutic, diagnosis, or theranostic (therapeutics + diagnosis) applications. We will offer a description of how, at the current state of the art, similar nanomedicine platforms are realized.

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Vorheriges Kapitel Contact-free Mechanical Manipulation of Biological Materials
Nächstes Kapitel Biological Molecules in Therapeutic Nanodevices
Literatur
21.1
W.R.S. Sanhai, J.H. Sakamoto, R. Canady, M. Ferrari: Seven challenges for nanomedicine, Nat. Nanotechnol. 3, 242–244 (2008)
21.2
21.3
K. Riehemann, S.W. Schneider, T.A. Luger, B. Godin, M. Ferrari, H. Fuchs: Nanomedicine–challenge and perspectives, Angewandte Chemie Int. Edn. 48(5), 872–897 (2009)
21.4
R. Petros, J. DeSimone: Strategies in the design of nanoparticles for therapeutic applications, Nat. Rev. Drug Discov. 9(8), 615–627 (2010)
21.5
M. Ferrari: Cancer nanotechnology: Opportunities and challenges, Nat. Rev. Cancer 5, 161–171 (2005)
21.6
W.M. Haynes (Ed.): CRC Handbook of Chemistry and Physics (CRC, Boulder 1998)
21.7
Z. Zhang, M.A. Horsch, M.H. Lamm, S.C. Glotzer: Tethered nano building blocks: Toward a conceptual framework for nanoparticle self-assembly, Nano Lett. 3(10), 1341–1346 (2003)
21.8
P.F. Damasceno, M. Engel, S.C. Glotzer: Predictive self-assembly of polyhedra into complex structures, Science 337, 453 (2012)
21.9
X. Lu, M. Rycenga, S. Skrabalak, B. Wiley, Y. Xia: Chemical synthesis of novel plasmonic nanoparticles, Ann. Rev. Phys. Chem. 60, 167–192 (2009)
21.10
M.G. Guzmán, J. Dille, S. Godet: Synthesis of silver nanoparticles by chemical reduction method and their antibacterial activity, Int. J. Chem. Biomol. Eng. 2(3), 104–111 (2009)
21.11
U. Mohanty: Electrodeposition: A versatile and inexpensive tool for the synthesis of nanoparticles, nanorods, nanowires, and nanoclusters of metals, J. Appl. Electrochem. 41, 257–270 (2011)
21.12
N. German, A. Ramanavicius, A. Ramanavicien: Electrochemical deposition of gold nanoparticles on graphite rod for glucose biosensing, Sens. Actuators B 203, 25–34 (2014)
21.13
J. Key, A.L. Palange, F. Gentile, S. Aryal, C. Stigliano, D. Di Mascolo, E. De Rosa, M. Cho, Y. Lee, J. Singh, P. Decuzzi: Soft discoidal polymeric nanoconstructs resist macrophage uptake and enhance vascular targeting in tumors, ACS Nano 9(12), 11628–11641 (2015)
21.14
C. Daraio, S. Jin: Synthesis and patterning methods for nanostructures useful for biological applications. In: Nanotechnology for Biology and Medicine at the Building Block Level, ed. by G.A. Silva, V. Parpura (Springer, New York 2012)
21.15
T.D.H. Le, W. Bonani, G. Speranza, V. Sglavo, R. Ceccato, D. Maniglio, A. Motta, C. Migliaresi: Processing and characterization of diatom nanoparticles and microparticles as potential source of silicon for bone tissue engineering, Mater. Sci. Eng. C 59, 471–479 (2016)
21.16
A. Jantschke, C. Fischer, R. Hensel, H.G. Braun, E. Brunner: Directed assembly of nanoparticles to isolated diatom valves using the non-wetting characteristics after pyrolysis, Nanoscale 6, 11637–11645 (2014)
21.17
S. Schlücker: Surface-enhanced Raman spectroscopy: Concepts and chemical applications, Angew. Chem. Int. Edn. 53(19), 4756–4795 (2014)
21.18
K. Kneipp, Y. Wang, H. Kneipp, L.T. Perelman, I. Itzkan, R.R. Dasari, M.S. Feld: Single molecule detection using surface-enhanced Raman scattering (SERS), Phys. Rev. Lett. 78, 1667–1670 (1997)
21.19
K. Kneipp, H. Kneipp, I. Itzkan, R.R. Dasari, M.S. Feld: Surface-enhanced Raman scattering and biophysics, J. Phys. Condens. Matter 14, R597–R624 (2002)
21.20
J. Kneipp, H. Kneipp, K. Kneipp: SERS-a single-molecule and nanoscale tool for bioanalytics, Chem. Soc. Rev. 37(5), 1052–1060 (2008)
21.21
S.T. Hunt, M. Milina, A.C. Alba-Rubio, C.H. Hendon, J.A. Dumesic, Y. Román-Leshkov: Self-assembly of noble metal monolayers on transition metal carbide nanoparticle catalysts, Science 352(6288), 974–978 (2016)
21.22
O. Govorov, H.H. Richardson: Generating heat with metal nanoparticles, Nano Today 2, 30–38 (2007)
21.23
G. Baffou, R. Quidan: Thermo-plasmonics: Using metallic nanostructures as nano-sources of heat, Laser Photonics Rev. 7(2), 171–187 (2013)
21.24
D. Maharaj, B. Bhushan: Scale effects of nanomechanical properties and deformation behavior of Au nanoparticle and thin film using depth sensing nanoindentation, J. Nanotechnol. 5, 822–836 (2014)
21.25
D. Maharaj, B. Bhushan: Nanomechanical behavior of MoS2 and WS2 multi-walled nanotubes and Carbon nanohorns, Sci. Rep. 5(8539), 1–9 (2015)
21.26
D. Chen, X. Qiao, X. Qiu, J. Chen: Synthesis and electrical properties of uniform silver nanoparticles for electronic applications, J. Mater. Sci. 44(4), 1076 (2009)
21.27
A.H. Alshehri, M. Jakubowska, A. Młożniak, M. Horaczek, D. Rudka, C. Free, J.D. Carey: Enhanced electrical conductivity of silver nanoparticles for high frequency electronic applications, ACS Appl. Mater. Interfaces 4(12), 7007–7010 (2012)
21.28
A. Akbarzadeh, M. Samiei, S. Davaran: Magnetic nanoparticles: Preparation, physical properties, and applications in biomedicine, Nanoscale Res. Lett. 7(1), 144 (2012)
21.29
B. Nawrot, E. Gaggelli: Understanding the chemical mechanisms of life, Nat. Chem. Biol. 3, 745–749 (2007)
21.30
G.M. Whitesides: The ‘right’ size in nanobiotechnology, Nat. Biotechnol. 21, 1161–1165 (2003)
21.31
W.F. Marshall, K.D. Young, M. Swaffer, E. Wood, P. Nurse, A. Kimura, J. Frankel, J. Wallingford, V. Walbot, X. Qu, A.H. Roeder: What determines cell size?, BMC Biology 10(101), 1–22 (2012) doi:10.​1186/​1741-7007-10-101 CrossRef
21.32
E. Hafen, H. Stocker: How are the sizes of cells, organs, and bodies controlled?, PLoS. Biol. 1(3), e86 (2003)
21.33
Y. Fung: Biomechanics, Mechanical Properties of Living Tissues (Springer, New York 1993)
21.34
M. Elsabahy, K.L. Wooley: Design of polymeric nanoparticles for biomedical delivery applications, Chem. Soc. Rev. 41, 2545–2561 (2012)
21.35
E. Tasciotti, X. Liu, R. Bhavane, K. Plant, A.D. Leonard, B.K. Price, M. Ming-Cheng Cheng, P. Decuzzi, J.M. Tour, F. Robertson, M. Ferrari: Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications, Nat. Nanotechnol. 3, 151–157 (2008)
21.36
E. Blanco, H. Shen, M. Ferrari: Principles of nanoparticle design for overcoming biological barriers to drug delivery, Nat. Biotechnol. 33, 941–951 (2015)
21.37
A. Parodi, N. Quattrocchi, A.L. van de Ven, C. Chiappini, M. Evangelopoulos, J.O. Martinez, B.S. Brown, S.Z. Khaled, I.K. Yazdi, M.V. Enzo, L. Isenhart, M. Ferrari, E. Tasciotti: Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions, Nat. Nanotechnol. 8, 61–68 (2013)
21.38
Z. Li, J.C. Barnes, A. Bosoy, J.F. Stoddart, J.I. Zink: Mesoporous silica nanoparticles in biomedical applications, Chem. Soc. Rev. 41, 2590–2605 (2012)
21.39
J.S. Ananta, B. Godin, R. Sethi, L. Moriggi, X. Liu, R.E. Serda, R. Krishnamurthy, R. Muthupillai, R.D. Bolskar, L. Helm, M. Ferrari, L.J. Wilson, P. Decuzzi: Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast, Nat. Nanotechnol. 5, 815–821 (2010)
21.40
L. Dykmana, N. Khlebtsov: Gold nanoparticles in biomedical applications: Recent advances and perspectives, Chem. Soc. Rev. 41, 2256–2282 (2012)
21.41
E.C. Dreaden, A.M. Alkilany, X. Huang, C.J. Murphy, M.A. El-Sayed: The golden age: Gold nanoparticles for biomedicine, Chem. Soc. Rev. 41, 2740–2779 (2012)
21.42
Q.H. Tran, V.Q.A.-T. Le Nguyen: Silver nanoparticles: Synthesis, properties, toxicology, applications and perspectives, Adv. Nat. Sci. Nanosci. Nanotechnol. 4, 033001 (2013)
21.43
S. Prabhu, E.K. Poulose: Silver nanoparticles: Mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects, Int. Nano Lett. 2(32), 1–10 (2012)
21.44
H.T. Nasrabadi, E. Abbasi, S. Davaran, M. Kouhi, A. Akbarzadeh: Bimetallic nanoparticles: Preparation, properties, and biomedical applications, Artif. Cells Nanomed. Biotechnol. 44, 376–380 (2016)
21.45
C. Xu, S. Sun: New forms of superparamagnetic nanoparticles for biomedical applications, Adv. Drug Deliv. Rev. 65, 732–743 (2013)
21.46
A.K. Gupta, M. Gupta: Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications, Biomaterials 26, 3995–4021 (2005)
21.47
J.H. Lee, J.-T. Jang, J.-S. Choi, S.H. Moon, S.-H. Noh, J.-W. Kim, J.-G. Kim, I.-S. Kim, K.I. Park, J. Cheon: Exchange-coupled magnetic nanoparticles for efficient heat induction, Nat. Nanotechnol. 6, 418–422 (2011)
21.48
H.L. Ferrand, S. Bolisetty, A.F. Demirors, R. Libanori, A.R. Studart, R. Mezzenga: Magnetic assembly of transparent and conducting graphene-based functional composites, Nat. Commun. 7, 12078 (2016)
21.49
L.Y. Chou, K. Zagorovsky, W.C. Chan: DNA assembly of nanoparticle superstructures for controlled biological delivery and elimination, Nat. Nanotechnol. 9, 148–155 (2014)
21.50
F. Danhier, E. Ansorena, J.M. Silva, R. Coco, A.L. Breton, V. Préat: PLGA-based nanoparticles: An overview of biomedical applications, J. Control. Release 161, 505–522 (2012)
21.51
21.52
C. Antoniades, C. Psarros, D. Tousoulis, C. Bakogiannis, C. Shirodaria, C. Stefanadis: Nanoparticles: A promising therapeutic approach in atherosclerosis, Curr. Drug Deliv. 7(4), 303–311 (2010)
21.53
21.54
A.L. van de Ven, P. Kim, O.A.H. Haley, J.R. Fakhoury, G. Adriani, J. Schmulen, P. Moloney, F. Hussain, M. Ferrari, X. Liu, S.-H. Yun, P. Decuzzi: Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution, J. Control. Release 158(1), 148–155 (2012) doi:10.​1016/​j.​jconrel.​2011.​10.​021 CrossRef
21.55
21.56
R.E. Serda, S. Ferrati, B. Godin, E. Tasciotti, X. Liu, M. Ferrari: Mitotic trafficking of silicon microparticles, Nanoscale 1(2), 250–259 (2009) doi:10.​1039/​B9NR00138G CrossRef
21.57
A.C. Anselmo, M. Zhang, S. Kumar, D.R. Vogus, S. Menegatti, M.E. Helgeson, S. Mitragotri: Elasticity of nanoparticles influences their blood circulation, phagocytosis, endocytosis, and targeting, ACS Nano 9(3), 3169–3177 (2015) doi:10.​1021/​acsnano.​5b00147 CrossRef
21.58
21.59
T.R. Lee, M. Choi, A.M. Kopacz, S.H. Yun, W.K. Liu, P. Decuzzi: On the near-wall accumulation of injectable particles in the microcirculation: Smaller is not better, Sci. Rep. 3, 2079 (2013) doi:10.​1038/​srep02079 CrossRef
21.60
T.R. Lee, M.S. Greene, Z. Jiang, A.M. Kopacz, P. Decuzzi, W. Chen, W.K. Liu: Quantifying uncertainties in the microvascular transport of nanoparticles, Biomech. Model. Mechanobiol. 13(3), 515–526 (2014) doi:10.​1007/​s10237-013-0513-0 CrossRef
21.61
M.D. de Tullio, P. De Palma, G. Iaccarino, G. Pascazio, M. Napolitano: An immersed boundary method for compressible flows using local grid refinement, J. Comput. Phys. 225(2), 2098–2117 (2007)MathSciNetMATH
21.62
S.S. Hossain, T.J. Hughes, P. Decuzzi: Vascular deposition patterns for nanoparticles in an inflamed patient-specific arterial tree, Biomech. Model. Mechanobiol. 13(3), 585–597 (2014) doi:10.​1007/​s10237-013-0520-1 CrossRef
21.63
S.S. Hossain, Y. Zhang, X. Liang, F. Hussain, M. Ferrari, T.J. Hughes, P. Decuzzi: In silico vascular modeling for personalized nanoparticle delivery, Nanomedicine 8(3), 343–357 (2013) doi:10.​2217/​nnm.​12.​124 CrossRef
21.64
A.J.C. Ladd: Numerical simulations of particulate suspensions via a discretized Boltzmann equation. Part 1. Theoretical foundation, J. Fluid Mech. 271, 285–309 (1994)MathSciNetMATH
21.65
A.J.C. Ladd: Numerical simulations of particulate suspensions via a discretized Boltzmann equation. Part 2. Numerical results, J. Fluid Mech. 271, 311–339 (1994)MathSciNetMATH
21.66
S. Succi: The Lattice Boltzmann Equation: For Fluid Dynamics and Beyond (Oxford University Press, Oxford 2001)MATH
21.67
21.68
A. Coclite, M.D. de Tullio, G. Pascazio, P. Decuzzi: A combined lattice Boltzmann and immersed boundary approach for predicting the vascular transport of differently shaped particles, Comput. Fluids 136, 260–271 (2016)MathSciNetMATH
21.69
21.70
21.71
C. Stigliano, J. Key, M. Ramirez, S. Aryal, P. Decuzzi: Radiolabeled polymeric nanoconstructs loaded with docetaxel and curcumin for cancer combinatorial therapy and nuclear imaging, Adv. Funct. Mater. 25(22), 3371–3379 (2015) doi:10.​1002/​adfm.​201500627 CrossRef
21.72
A. Lee, D. Di Mascolo, M. Francardi, F. Piccardi, T. Bandiera, P. Decuzzi: Spherical polymeric nanoconstructs for combined chemotherapeutic and anti-inflammatory therapies, Nanomedicine 12(7), 2139–2147 (2016) doi:10.​1016/​j.​nano.​2016.​05.​012 CrossRef
21.73
21.74
21.75
21.76
21.77
21.78
H. Ouyang, M. Christophersen, P.M. Fauchet: Enhanced control of porous silicon morphology from macropore to mesopore formation, Phys. Stat. Sol. A 202(8), 1396–1401 (2005) doi:10.​1002/​pssa.​200461112 CrossRef
21.79
L. Xiao, L. Gu, S.B. Howell, M.J. Sailor: Porous silicon nanoparticle photosensitizers for singlet oxygen and their phototoxicity against cancer cells, ACS Nano 5, 3651–3659 (2011)
21.80
21.81
C. Chiappini, E. De Rosa, J.O. Martinez, X. Liu, J. Steele, M.M. Stevens, E. Tasciotti: Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization, Nat. Mater. 14(5), 532–539 (2015) doi:10.​1038/​nmat4249 CrossRef
21.82
21.83
F. Dai, J. Zai, R. Yi, M.L. Gordin, H. Sohn, S. Chen, D. Wang: Bottom-up synthesis of high surface area mesoporous crystalline silicon and evaluation of its hydrogen evolution performance, Nat. Comm. 5, 1–11 (2014) doi:10.​1038/​ncomms4605 CrossRef
21.84
L. Batchelor, A. Loni, L.T. Canham, M. Hasan, J.L. Coffer: Manufacture of mesoporous silicon from living plants and agricultural waste: An environmentally friendly and scalable process, Silicon 4(4), 259–266 (2012) doi:10.​1007/​s12633-012-9129-8 CrossRef
21.85
M.J. Sailor: Fundamentals of porous silicon preparation. In: Porous Silicon in Practice (Wiley-VCH, Weinheim 2012) pp. 1–42
21.86
21.87
S.F. Chuang, S.D. Collins, R.L. Smith: Preferential propagation of pores during the formation of porous silicon: A transmission electron microscopy study, Appl. Phys. Lett. 55(7), 675 (1989) doi:10.​1063/​1.​101819 CrossRef
21.88
H. Foll, M. Christophersen, J. Carstensen, G. Hasse: Formation and application of porous silicon, Mater. Sci. Eng. 39, 93–141 (2002)
21.89
L.T. Canham, L. Canham (Eds.): Handbook of Porous Silicon (Springer, Cham 2014)
21.90
M.G. Berger, R. Arens-Fischer, M. Thönissen, M. Krüger, S. Billat, H. Lüth, S. Hilbrich, W. Theiß, P. Grosse: Dielectric filters made of PS: Advanced performance by oxidation and new layer structures, Thin Sol. Films 297(1/2), 237–240 (1997) doi:10.​1016/​S0040-6090(96)09361-3 CrossRef
21.91
F. Cunin, T.A. Schmedake, J.R. Link, Y.Y. Li, J. Koh, S.N. Bhatia, M.J. Sailor: Biomolecular screening with encoded porous-silicon photonic crystals, Nat. Mater. 1(1), 39–41 (2002) doi:10.​1038/​nmat702 CrossRef
21.92
21.93
T.A. Schmedake, F. Cunin, J.R. Link, M.J. Sailor: Standoff detection of chemicals using porous silicon ‘‘smart dust’’ particles, Adv. Mater. 14(18), 1270–1272 (2002)
21.94
J. Salonen, L. Laitinen, A. Kaukonen, J. Tuura, M. Bjorkqvist, T. Heikkila, K. Vahaheikkila, J. Hirvonen, V. Lehto: Mesoporous silicon microparticles for oral drug delivery: Loading and release of five model drugs, J. Control. Release 108(2/3), 362–374 (2005) doi:10.​1016/​j.​jconrel.​2005.​08.​017 CrossRef
21.95
H.A. Santos, J. Riikonen, J. Salonen, E. Mäkilä, T. Heikkilä, T. Laaksonen, L. Peltonen, V.P. Lehto, J. Hirvonen: In vitro cytotoxicity of porous silicon microparticles: Effect of the particle concentration, surface chemistry and size, Acta. Biomater. 6(7), 2721–2731 (2010) doi:10.​1016/​j.​actbio.​2009.​12.​043 CrossRef
21.96
J.-H. Park, L. Gu, G. von Maltzahn, E. Ruoslahti, S.N. Bhatia, M.J. Sailor: Biodegradable luminescent porous silicon nanoparticles for in vivo applications, Nat. Mater. 8(4), 331–336 (2009) doi:10.​1038/​nmat2398 CrossRef
21.97
R.A. Petros, J.M. DeSimone: Strategies in the design of nanoparticles for therapeutic applications, Nat. Rev. Drug Discov. 9(8), 615–627 (2010) doi:10.​1038/​nrd2591 CrossRef
21.98
S.E.A. Gratton, P.A. Ropp, P.D. Pohlhaus, J.C. Luft, V.J. Madden, M.E. Napier, J.M. DeSimone: The effect of particle design on cellular internalization pathways, Proc. Natl. Acad. Sci. 105(33), 11613–11618 (2008) doi:10.​1073/​pnas.​0801763105 CrossRef
21.99
B. Godin, C. Chiappini, S. Srinivasan, J.F. Alexander, K. Yokoi, M. Ferrari, P. Decuzzi, X. Liu: Discoidal porous silicon particles: Fabrication and biodistribution in breast cancer bearing mice, Adv. Funct. Mater. 22(20), 4225–4235 (2012) doi:10.​1002/​adfm.​201200869 CrossRef
21.100
C. Chiappini, E. Tasciotti, J.R. Fakhoury, D. Fine, L. Pullan, Y.C. Wang, L. Fu, X. Liu, M. Ferrari: Tailored porous silicon microparticles: Fabrication and properties, Chem. Phys. Chem. 11(5), 1029–1035 (2010) doi:10.​1002/​cphc.​200900914 CrossRef
21.101
C. Chiappini, E. Tasciotti, R.E. Serda, L. Brousseau, X. Liu, M. Ferrari: Mesoporous silicon particles as intravascular drug delivery vectors: Fabrication, in-vitro, and in-vivo assessments, Phys. Stat. Sol. C 8(6), 1826–1832 (2011) doi:10.​1002/​pssc.​201000344 CrossRef
21.102
C. Zhang, C. Li, Z. Liu, J. Zheng, C. Xue, Y. Zuo, B. Cheng, Q. Wang: Electrically conductive and optically active porous silicon nanowires, Nano. Lett. 9(12), 4539–4543 (2009) doi:10.​1021/​nl903030h CrossRef
21.103
21.104
N. Geyer, B. Fuhrmann, Z. Huang, J. de Boor, H.S. Leipner, P. Werner: Model for the mass transport during metal-assisted chemical etching with contiguous metal films as catalysts, J. Phys. Chem. C 116(24), 13446–13451 (2012) doi:10.​1021/​jp3034227 CrossRef
21.105
X. Zhong, Y. Qu, Y.-C. Lin, L. Liao, X. Duan: Unveiling the formation pathway of single crystalline porous silicon nanowires, ACS Appl. Mater. Interf. 3(2), 261–270 (2011) doi:10.​1021/​am1009056 CrossRef
21.106
21.107
M. Coluccio, F. Gentile, M. Francardi, G. Perozziello, N. Malara, P. Candeloro, E. Di Fabrizio: Electroless deposition and nanolithography can control the formation of materials at the nano-scale for plasmonic applications, Sensors 14(4), 6056–6083 (2014) doi:10.​3390/​s140406056 CrossRef
21.108
R. Elnathan, L. Isa, D. Brodoceanu, A. Nelson, F.J. Harding, B. Delalat, T. Kraus, N.H. Voelcker: Versatile particle-based route to engineer vertically aligned silicon nanowire arrays and nanoscale pores, ACS Appl. Mater. Interf. 7(42), 23717–23724 (2015) doi:10.​1021/​acsami.​5b07777 CrossRef
21.109
H. Alhmoud, B. Delalat, R. Elnathan, A.C. Rius, A. Chaix, M.L. Rogers, J.-O. Durand, N.H. Voelcker: Porous silicon nanodiscs for targeted drug delivery, Adv. Funct. Mater. 25(7), 1137–1145 (2015) doi:10.​1002/​adfm.​201403414 CrossRef
21.110
H. Lin, H.-Y. Cheung, F. Xiu, F. Wang, S. Yip, N. Han, T. Hung, J. Zhou, J.C. Ho, C.-Y. Wong: Developing controllable anisotropic wet etching to achieve silicon nanorods, nanopencils and nanocones for efficient photon trapping, J. Mater. Chem. A 1(34), 9942–9946 (2013) doi:10.​1039/​C3TA11889D CrossRef
21.111
F. Gentile, M.L. Coluccio, R.P. Zaccaria, M. Francardi, G. Cojoc, G. Perozziello, R. Raimondo, P. Candeloro, E. Di Fabrizio: Selective on site separation and detection of molecules in diluted solutions with super-hydrophobic clusters of plasmonic nanoparticles, Nanoscale 6(14), 8208–8225 (2014) doi:10.​1039/​C4NR00796D CrossRef
21.112
G.S. Higashi, Y.J. Chabal, G.W. Trucks, K. Raghavachari: Ideal hydrogen termination of the Si (111) surface, Appl. Phys. Lett. 56(7), 656–658 (1990) doi:10.​1063/​1.​102728 CrossRef
21.113
21.114
21.115
21.116
21.117
J. Riikonen, M. Salomäki, J. van Wonderen, M. Kemell, W. Xu, O. Korhonen, M. Ritala, F. MacMillan, J. Salonen, V.P. Lehto: Surface chemistry, reactivity, and pore structure of porous silicon oxidized by various methods, Langmuir 28(28), 10573–10583 (2012) doi:10.​1021/​la301642w CrossRef
21.118
J.B. Brzoska, I.B. Azouz, F. Rondelez: Silanization of solid substrates: A step toward reproducibility, Langmuir 10(11), 4367–4373 (1994), doi:10.1021/la00023a072
21.119
G.T. Hermanson: Bioconjugate Techniques, 3rd edn. (Elsevier, Amsterdam 2013)
21.120
21.121
21.122
21.123
R.E. Serda, A. Mack, M. Pulikkathara, A.M. Zaske, C. Chiappini, J.R. Fakhoury, D. Webb, B. Godin, J.L. Conyers, X.W. Liu, J.A. Bankson, M. Ferrari: Cellular association and assembly of a multistage delivery system, Small 6(12), 1329–1340 (2010) doi:10.​1002/​smll.​201000126 CrossRef
21.124
S.H.C. Anderson, H. Elliott, D.J. Wallis, L.T. Canham, J.J. Powell: Dissolution of different forms of partially porous silicon wafers under simulated physiological conditions, Phys. Stat. Sol A 197(2), 331–335 (2003) doi:10.​1002/​pssa.​200306519 CrossRef
21.125
B. Godin, J. Gu, R.E. Serda, R. Bhavane, E. Tasciotti, C. Chiappini, X. Liu, T. Tanaka, P. Decuzzi, M. Ferrari: Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation, J. Biomed. Mater. Res. A 94A(4), 1236–1243 (2010) doi:10.​1002/​jbm.​a.​32807 CrossRef
21.126
W. Sun, J.E. Puzas, T.J. Sheu, X. Liu, P.M. Fauchet: Nano-to microscale porous silicon as a cell interface for bone-tissue engineering, Adv. Mater. 19(7), 921–924 (2007) doi:10.​1002/​adma.​200600319 CrossRef
21.127
T. Jalkanen, E. Mäkilä, Y.I. Suzuki, T. Urata, K. Fukami, T. Sakka, J. Salonen, Y.H. Ogata: Studies on chemical modification of porous silicon-based graded-index optical microcavities for improved stability under alkaline conditions, Adv. Funct. Mater. 22(18), 3890–3898 (2012) doi:10.​1002/​adfm.​201200386 CrossRef
21.128
A.T. Balter, Z. Shatsberg, M. Beckerman, E. Segal, N. Artzi: Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues, Nat. Comm. 6, 6208 (2015) doi:10.​1038/​ncomms7208 CrossRef
21.129
T. Tanaka, B. Godin, R. Bhavane, R.N. Alicea, J. Gu, X. Liu, C. Chiappini, J.R. Fakhoury, S. Amra, A. Ewing: In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice, Int. J. Pharm. 402(1/2), 190–197 (2010) doi:10.​1016/​j.​ijpharm.​2010.​09.​015 CrossRef
21.130
L. Gu, D.J. Hall, Z. Qin, E. Anglin, J. Joo, D.J. Mooney, S.B. Howell, M.J. Sailor: In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles, Nat. Comm. 4, 1–7 (2013) doi:10.​1038/​ncomms3326 CrossRef
21.131
M. Ariza-Avidad, A. Nieto, A.S. alinas-Castillo, L.F. Capitan-Vallvey, G.M. Miskelly, M.J. Sailor: Monitoring of degradation of porous silicon photonic crystals using digital photography, Nanoscale Res. Lett. 9(1), 410 (2014) doi:10.​1186/​1556-276X-9-410 CrossRef
21.132
S.P. Low, K.A. Williams, L.T. Canham, N.H. Voelcker: Generation of reactive oxygen species from porous silicon microparticles in cell culture medium, J. Biomed. Mater. Res. A 93A(3), 1124–1131 (2010) doi:10.​1002/​jbm.​a.​32610 CrossRef
21.133
21.134
21.135
L.M. Bimbo, M. Sarparanta, H.A. Santos, A.J. Airaksinen, E. Mäkilä, T. Laaksonen, L. Peltonen, V.P. Lehto, J. Hirvonen, J. Salonen: Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats, ACS Nano 4(6), 3023–3032 (2010) doi:10.​1021/​nn901657w CrossRef
21.136
21.137
A.S.-W. Goh, A.Y.-F. Chung, R.H.-G. Lo, T.-N. Lau, S.W.-K. Yu, M. Chng, S. Satchithanantham, S.L.-E. Loong, D.C.-E. Ng, B.-C. Lim, S. Connor, P.K.-H. Chow: A novel approach to brachytherapy in hepatocellular carcinoma using a phosphorous32 (32P) brachytherapy delivery device – A first-in-man study, Int. J. Radiat. Oncol. Biol. Phys. 67(3), 786–792 (2007) doi:10.​1016/​j.​ijrobp.​2006.​09.​011 CrossRef
21.138
21.139
S. Ferrati, A. Mack, C. Chiappini, X. Liu, A.J. Bean, M. Ferrari, R.E. Serda: Intracellular trafficking of silicon particles and logic-embedded vectors, Nanoscale 2(8), 1512–1520 (2010) doi:10.​1039/​C0NR00227E CrossRef
21.140
E. Tasciotti, B. Godin, J.O. Martinez, C. Chiappini, R.C. Bhavane, X. Liu, M. Ferrari: Near-infrared imaging method for the in vivo assessment of the biodistribution of nanoporous silicon particles, Mol. Imag. 10(1), 56 (2011)
21.141
E. De Rosa, C. Chiappini, D. Fan, X. Liu, M. Ferrari, E. Tasciotti: Agarose surface coating influences intracellular accumulation and enhances payload stability of a nano-delivery system, Pharm. Res. 28(7), 1520–1530 (2011) doi:10.​1007/​s11095-011-0453-2 CrossRef
21.142
D. Liu, L.M. Bimbo, E. Mäkilä, F. Villanova, M. Kaasalainen, B. Herranz-Blanco, C.M. Caramella, V.P. Lehto, J. Salonen, K.-H. Herzig, J. Hirvonen, H.A. Santos: Co-delivery of a hydrophobic small molecule and a hydrophilic peptide by porous silicon nanoparticles, J. Control. Release 170(2), 268–278 (2013) doi:10.​1016/​j.​jconrel.​2013.​05.​036 CrossRef
21.143
M. Xue, X. Zhong, Z. Shaposhnik, Y. Qu, F. Tamanoi, X. Duan, J.I. Zink: pH-operated mechanized porous silicon nanoparticles, J. Am. Chem. Soc. 133(23), 8798–8801 (2011) doi:10.​1021/​ja201252e CrossRef
21.144
A.P. Mann, T. Tanaka, A. Somasunderam, X. Liu, D.G. Gorenstein, M. Ferrari: E-selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow, Adv. Mater. 23(36), H278–H282 (2011) doi:10.​1002/​adma.​201101541 CrossRef
21.145
E. Secret, M. Maynadier, A. Gallud, M.G. Bobo, A. Chaix, E. Belamie, P. Maillard, M.J. Sailor, M. Garcia, J.O. Durand, F. Cunin: Anionic porphyrin -grafted porous silicon nanoparticles for photodynamic therapy, Chem. Comm. 49(39), 4202–4204 (2013) doi:10.​1039/​C3CC38837A CrossRef
21.146
M. Wang, J.L. Coffer, K. Dorraj, P.S. Hartman, A. Loni, L.T. Canham: Sustained antibacterial activity from triclosan-loaded nanostructured mesoporous silicon, Mol. Pharm. 7(6), 2232–2239 (2010) doi:10.​1021/​mp100227m CrossRef
21.147
R. Xu, G. Zhang, J. Mai, X. Deng, V. Segura-Ibarra, S. Wu, J. Shen, H. Liu, Z. Hu, L. Chen, Y. Huang, E. Koay, Y. Huang, J. Liu, J.E. Ensor, E. Blanco, X. Liu, M. Ferrari, H. Shen: An injectable nanoparticle generator enhances delivery of cancer therapeutics, Nat. Biotechnol. 34(4), 414–418 (2016) doi:10.​1038/​nbt.​3506 CrossRef
21.148
J.O. Martinez, M. Evangelopoulos, V. Karun, E. Shegog, J.A. Wang, C. Boada, X. Liu, M. Ferrari, E. Tasciotti: The effect of multistage nanovector targeting of VEGFR2 positive tumor endothelia on cell adhesion and local payload accumulation, Biomaterials 35(37), 9824–9832 (2014) doi:10.​1016/​j.​biomaterials.​2014.​08.​024 CrossRef
21.149
L. Gu, L.E. Ruff, Z. Qin, M. Corr, S.M. Hedrick, M.J. Sailor: Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody, Adv. Mater. 24(29), 3981–3987 (2012) doi:10.​1002/​adma.​201200776 CrossRef
21.150
C. Chiappini, J.O. Martinez, E. De Rosa, C.S. Almeida, E. Tasciotti, M.M. Stevens: Biodegradable nanoneedles for localized delivery of nanoparticles in vivo: Exploring the biointerface, ACS Nano 9, 5500–5509 (2015) doi:10.​1021/​acsnano.​5b01490 CrossRef
21.151
M.M. Orosco, C. Pacholski, G.M. Miskelly, M.J. Sailor: Protein-coated porous-silicon photonic crystals for amplified optical detection of protease activity, Adv. Mater. 18(11), 1393–1396 (2006) doi:10.​1002/​adma.​200502420 CrossRef
21.152
C. Chiappini, P. Campagnolo, C.S. Almeida, N. Annassi-Ghadi, L.W. Chow, G.B. Hanna, M.M. Stevens: Mapping Local cytosolic enzymatic activity in human esophageal mucosa with porous silicon nanoneedles, Adv. Mater. 27(35), 5147–5152 (2015) doi:10.​1002/​adma.​201501304 CrossRef
21.153
A. Caliò, I. Rea, J. Politi, P. Giardina, S. Longobardi, L.D. Stefano: Hybrid bio/non-bio interfaces for protein-glucose interaction monitoring, J. Appl. Phys. 114(13), 134904 (2013) doi:10.​1063/​1.​4824379 CrossRef
21.154
G. Rong, J.D. Ryckman, R.L. Mernaugh, S.M. Weiss: Label-free porous silicon membrane waveguide for DNA sensing, Appl. Phys. Lett. 93(16), 161109 (2008) doi:10.​1063/​1.​3005620 CrossRef
21.155
N. Massad-Ivanir, G. Shtenberg, A. Tzur, M.A. Krepker, E. Segal: Engineering nanostructured porous SiO2 surfaces for bacteria detection via ‘‘direct cell capture’’, Anal. Chem. 83(9), 3282–3289 (2011) doi:10.​1021/​ac200407w CrossRef
21.156
L. De Stefano, I. Rea, I. Rendina, L. Rotiroti, M. Rossi, S. D'Auria: Resonant cavity enhanced optical microsensor for molecular interactions based on porous silicon, Phys. Stat. Sol. A 203(5), 886–891 (2006) doi:10.​1002/​pssa.​200521350 CrossRef
21.157
S. D'Auria, M. de Champdoré, V. Aurilia, A. Parracino, M. Staiano, A. Vitale, M. Rossi, I. Rea, L. Rotiroti, A.M. Rossi, S. Borini, I. Rendina, L. De Stefano: Nanostructured silicon-based biosensors for the selective identification of analytes of social interest, J. Phys. Condens. Matter 18(33), S2019–S2028 (2006) doi:10.​1088/​0953-8984/​18/​33/​S17 CrossRef
21.158
21.159
J. Zhang, Y. Wu, B. Zhang, M. Li, S. Jia, S. Jiang, H. Zhou, Y. Zhang, C. Zhang, A.P.F. Turner: Label-free electrochemical detection of tetracycline by an aptamer nano-biosensor, Anal. Lett. 45(9), 986–992 (2012) doi:10.​1080/​00032719.​2012.​670784 CrossRef
21.160
L.A. Osminkina, V.A. Sivakov, G.A. Mysov, V.A. Georgobiani, U.A. Natashina, F. Talkenberg, V.V. Solovyev, A.A. Kudryavtsev, V.Y. Timoshenko: Nanoparticles prepared from porous silicon nanowires for bio-imaging and sonodynamic therapy, Nanoscale Res. Lett. 9(1), 1 (2014) doi:10.​1186/​1556-276X-9-463 CrossRef
21.161
A. Gizzatov, C. Stigliano, J.S. Ananta, R. Sethi, R. Xu, A. Guven, M. Ramirez, H. Shen, A. Sood, M. Ferrari, L.J. Wilson, X. Liu, P. Decuzzi: Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer, Cancer Lett. 352(1), 97–101 (2014) doi:10.​1016/​j.​canlet.​2014.​06.​001 CrossRef
21.162
R. Duncan, R. Gaspar: Nanomedicine (s) under the microscope, Mol. Pharm. 8(6), 2101–2141 (2011)
21.163
W.B. Liechty, D.R. Kryscio, B.V. Slaughter, N.A. Peppas: Polymers for drug delivery systems, Annu. Rev. Chem. Biomol. Eng. 1, 149 (2010)
21.164
Y.H. Yun, B.K. Lee, K. Park: Controlled drug delivery: Historical perspective for the next generation, J. Control. Release 219, 2–7 (2011)
21.165
H.A. Santos: Porous Silicon for Biomedical Applications (Elsevier, Amsterdam 2014)
21.166
N. Shrestha, M.-A. Shahbazi, F. Araújo, E. Mäkilä, J. Raula, E.I. Kauppinen, J. Salonen, B. Sarmento, J. Hirvonen, H.A. Santos: Multistage pH-responsive mucoadhesive nanocarriers prepared by aerosol flow reactor technology: A controlled dual protein-drug delivery system, Biomaterials 68, 9–20 (2015)
21.167
M.K. Marschütz, A. Bernkop-Schnürch: Oral peptide drug delivery: polymer–inhibitor conjugates protecting insulin from enzymatic degradation in vitro, Biomaterials 21(14), 1499–1507 (2000)
21.168
S. Munier, I. Messai, T. Delair, B. Verrier, Y. Ataman-Önal: Cationic PLA nanoparticles for DNA delivery: Comparison of three surface polycations for DNA binding, protection and transfection properties, Colloids Surf. B 43(3), 163–173 (2005)
21.169
H.S. Choi, W. Liu, P. Misra, E. Tanaka, J.P. Zimmer, B.I. Ipe, M.G. Bawendi, J.V. Frangioni: Renal clearance of quantum dots, Nat. Biotechnol. 25(10), 1165–1170 (2007)
21.170
M.I. Stockman, D.J. Bergman, T. Kobayashi: Coherent control of nanoscale localization of ultrafast optical excitation in nanosystems, Phys. Rev. B 69, 054202 (2004)
21.171
S. Stolnik, L. Illum, S. Davis: Long circulating microparticulate drug carriers, Adv. Drug Deliv. Rev. 64, 290–301 (2012)
21.172
H.A. Santos, E. Mäkilä, A.J. Airaksinen, L.M. Bimbo, J. Hirvonen: Porous silicon nanoparticles for nanomedicine: Preparation and biomedical applications, Nanomedicine 9(4), 535–554 (2014)
21.173
H.A. Santos, J. Hirvonen: Nanostructured porous silicon materials: Potential candidates for improving drug delivery, Nanomedicine 7(9), 1281–1284 (2012)
21.174
F. Fontana, M.P. Ferreira, A. Correia, J. Hirvonen, H.A. Santos: Microfluidics as a cutting-edge technique for drug delivery applications, J. Drug Deliv. Sci. Technol. 34, 76–87 (2016)
21.175
I. Polenz, D.A. Weitz, J.-C. Baret: Polyurea microcapsules in microfluidics: Surfactant control of soft membranes, Langmuir 31(3), 1127–1134 (2015)
21.176
A. Utada, L.-Y. Chu, A. Fernandez-Nieves, D. Link, C. Holtze, D. Weitz: Dripping, jetting, drops, and wetting: The magic of microfluidics, MRS Bull. 32(09), 702–708 (2007)
21.177
A.S. Utada, A. Fernandez-Nieves, H.A. Stone, D.A. Weitz: Dripping to jetting transitions in coflowing liquid streams, Phys. Rev. Lett. 99(9), 094502 (2007)
21.178
Y. Kim, B.L. Chung, M. Ma, W.J. Mulder, Z.A. Fayad, O.C. Farokhzad, R. Langer: Mass production and size control of lipid–polymer hybrid nanoparticles through controlled microvortices, Nano Lett. 12(7), 3587–3591 (2012)
21.179
P.M. Valencia, O.C. Farokhzad, R. Karnik, R. Langer: Microfluidic technologies for accelerating the clinical translation of nanoparticles, Nat. Nanotechnol. 7(10), 623–629 (2012) doi:10.​1038/​nnano.​2012.​168 CrossRef
21.180
E.F. Petricoin, D.K. Ornstein, C.P. Paweletz, A. Ardekani, P.S. Hackett, B.A. Hitt, A. Velasco, C. Trucco, L. Wiegand, K. Wood, C.B. Simone, P.J. Levine, W.M. Linehan, M.R.E. Buck, S.M. Steinberg, E.C. Kohn, L.A. Liotta: Serum proteomic patterns for detection of prostate cancer, J. Natl. Cancer Inst. 94(20), 1576–1578 (2002)
21.181
T. Rossow, J.A. Heyman, A.J. Ehrlicher, A. Langhoff, D.A. Weitz, R. Haag, S. Seiffert: Controlled synthesis of cell-laden microgels by radical-free gelation in droplet microfluidics, J. Am. Chem. Soc. 134(10), 4983–4989 (2012) doi:10.​1021/​Ja300460p CrossRef
21.182
21.183
A. Manz, D.J. Harrison, E.M. Verpoorte, J.C. Fettinger, A. Paulus, H. Lüdi, H.M. Widmer: Planar chips technology for miniaturization and integration of separation techniques into monitoring systems: Capillary electrophoresis on a chip, J. Chromatogr. A 593(1), 253–258 (1992)
21.184
Y. Hu, A. Bouamrani, E. Tasciotti, L. Li, X. Liu, M. Ferrari: Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein, ACS Nano 4(1), 439–451 (2010)
21.185
J.S. Sander, L. Isa, P.A. Rühs, P. Fischer, A.R. Studart: Stabilization mechanism of double emulsions made by microfluidics, Soft Matter 8(45), 11471–11477 (2012)
21.186
L.R. Arriaga, S.S. Datta, S.H. Kim, E. Amstad, T.E. Kodger, F. Monroy, D.A. Weitz: Ultrathin shell double emulsion templated giant unilamellar lipid vesicles with controlled microdomain formation, Small 10(5), 950–956 (2014)
21.187
S. Nie, S.R. Emory: Probing single molecules and single nanoparticles by surface-enhanced Raman scattering, Science 275(5303), 1102–1106 (1997)
21.188
Y.-C. Tan, V. Cristini, A.P. Lee: Monodispersed microfluidic droplet generation by shear focusing microfluidic device, Sens. Actuators B 114(1), 350–356 (2006)
21.189
J.C. Stachowiak, D.L. Richmond, T.H. Li, A.P. Liu, S.H. Parekh, D.A. Fletcher: Unilamellar vesicle formation and encapsulation by microfluidic jetting, Proc. Natl. Acad. Sci. 105(12), 4697–4702 (2008)
21.190
G. Whitesides, A. Stroock:: Flexible methods for microfluidics, J. Phys. Today 54(6), 42–48 (2001)
21.191
A.S. Utada, E. Lorenceau, D.R. Link, P.D. Kaplan, H.A. Stone, D.A. Weitz: Monodisperse double emulsions generated from a microcapillary device, Science 308(5721), 537–541 (2005) doi:10.​1126/​science.​1109164 CrossRef
21.192
S. Yang, F. Guo, B. Kiraly, X. Mao, M. Lu, K.W. Leong, T.J. Huang: Microfluidic synthesis of multifunctional Janus particles for biomedical applications, Lab Chip 12(12), 2097–2102 (2012) doi:10.​1039/​c2lc90046g CrossRef
21.193
S. Mazzitelli, L. Capretto, F. Quinci, R. Piva, C. Nastruzzi: Preparation of cell-encapsulation devices in confined microenvironment, Adv. Drug Deliv. Rev. 65(11/12), 1533–1555 (2013)
21.194
Y. Kim, F. Fay, D.P. Cormode, B.L. Sanchez-Gaytan, J. Tang, E.J. Hennessy, M.M. Ma, K. Moore, O.C. Farokhzad, E.A. Fisher, W.J.M. Mulder, R. Langer, Z.A. Fayad: Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics, ACS Nano 7(11), 9975–9983 (2013) doi:10.​1021/​Nn4039063 CrossRef
21.195
H.A. Santos: Opinion paper: Microfluidics technique to revolutionize the drug delivery field: Current developments and applications, Curr. Drug Deliv. 12(6), 642–644 (2015)
21.196
21.197
R. Karnik, F. Gu, P. Basto, C. Cannizzaro, L. Dean, W. Kyei-Manu, R. Langer, O.C. Farokhzad: Microfluidic platform for controlled synthesis of polymeric nanoparticles, Nano Lett. 8(9), 2906–2912 (2008)
21.198
S.H. Kim, J.W. Kim, D.H. Kim, S.H. Han, D.A. Weitz: Polymersomes containing a hydrogel network for high stability and controlled release, Small 9(1), 124–131 (2013)
21.199
S. Stainmesse, H. Fessi, J.P. Devissaguet, F. Puisieux, C. Theis: Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles, US Patent 5133908 (US005133908A) (1992)
21.200
F. Ganachaud, J.L. Katz: Nanoparticles and nanocapsules created using the Ouzo effect: Spontaneous emulsification as an alternative to ultrasonic and high-shear devices, Chem. Phys. Chem. 6(2), 209–216 (2005)
21.201
F. Kong, X. Zhang, H. Zhang, X. Qu, D. Chen, M. Servos, E. Mäkilä, J. Salonen, H.A. Santos, M. Hai, D.A. Weitz: Inhibition of multidrug resistance of cancer cells by co-delivery of DNA nanostructures and drugs using porous silicon nanoparticles@giant liposomes, Adv. Funct. Mater. 25(22), 3330–3340 (2015) doi:10.​1002/​adfm.​201500594 CrossRef
21.202
F. Araujo, N. Shrestha, M.A. Shahbazi, D. Liu, B. Herranz-Blanco, E.M. Makila, J.J. Salonen, J.T. Hirvonen, P.L. Granja, B. Sarmento, H.A. Santos: Microfluidic assembly of a multifunctional tailorable composite system designed for site specific combined oral delivery of peptide drugs, ACS Nano 9(8), 8291–8302 (2015) doi:10.​1021/​acsnano.​5b02762 CrossRef
21.203
H. Zhang, D. Liu, M.A. Shahbazi, E. Makila, B. Herranz-Blanco, J. Salonen, J. Hirvonen, H.A. Santos: Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix, Adv. Mater. 26(26), 4497–4503 (2014) doi:10.​1002/​adma.​201400953 CrossRef
21.204
D. Liu, H. Zhang, B.-H. Blanco, E. Makila, V.P. Lehto, J. Salonen, J. Hirvonen, H.A. Santos: Microfluidic assembly of monodisperse multistage pH-responsive polymer/porous silicon composites for precisely controlled multi-drug delivery, Small 10(10), 2029–2038 (2014) doi:10.​1002/​smll.​201303740 CrossRef
21.205
D. Liu, B. Herranz-Blanco, E. Makila, L.R. Arriaga, S. Mirza, D.A. Weitz, N. Sandler, J. Salonen, J. Hirvonen, H.A. Santos: Microfluidic templated mesoporous silicon-solid lipid microcomposites for sustained drug delivery, ACS Appl. Mater. Interfaces 5(22), 12127–12134 (2013) doi:10.​1021/​am403999q CrossRef
21.206
A. Jahn, S.M. Stavis, J.S. Hong, W.N. Vreeland, D.L. Devoe, M. Gaitan: Microfluidic mixing and the formation of nanoscale lipid vesicles, ACS Nano 4(4), 2077–2087 (2010) doi:10.​1021/​Nn901676x CrossRef
21.207
Y.T. Kim, B.L. Chung, M.M. Ma, W.J.M. Mulder, Z.A. Fayad, O.C. Farokhzad, R. Langer: Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices, Nano Lett. 12(7), 3587–3591 (2012) doi:10.​1021/​Nl301253v CrossRef
21.208
N. Kolishetti, S. Dhar, P.M. Valencia, L.Q. Lin, R. Karnik, S.J. Lippard, R. Langer, O.C. Farokhzad: Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy, Proc. Natl. Acad. Sci. 107(42), 17939–17944 (2010) doi:10.​1073/​pnas.​1011368107 CrossRef
21.209
A. Jahn, W.N. Vreeland, M. Gaitan, L.E. Locascio: Controlled vesicle self-assembly in microfluidic channels with hydrodynamic focusing, J. Am. Chem. Soc. 126(9), 2674–2675 (2004) doi:10.​1021/​Ja0318030 CrossRef
21.210
C.J. Thiele: Neuroblastoma. In: Human Cell Culture, Vol. 1, ed. by J.R.W. Masters, B. Palsson (Springer, Dordrecht 1998) pp. 21–53
21.211
J.O. McNamara, E.R. Andrechek, Y. Wang, K.D. Viles, R.E. Rempel, E. Gilboa, B.A. Sullenger, P.H. Giangrande: Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras, Nat. Biotechnol. 24(8), 1005–1015 (2006) doi:10.​1038/​Nbt1223 CrossRef
21.212
F.S. Majedi, M.M. Hasani-Sadrabadi, J.J. VanDersarl, N. Mokarram, S. Hojjati-Emami, E. Dashtimoghadam, S. Bonakdar, M.A. Shokrgozar, A. Bertsch, P. Renaud: On-chip fabrication of paclitaxel-loaded chitosan nanoparticles for cancer therapeutics, Adv. Funct. Mater. 24(4), 432–441 (2014)
21.213
A.J. Mieszawska, Y. Kim, A. Gianella, I. van Rooy, B. Priem, M.P. Labarre, C. Ozcan, D.P. Cormode, A. Petrov, R. Langer, O.C. Farokhzad, Z.A. Fayad, W.J.M. Mulder: Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy, Bioconj. Chem. 24(9), 1429–1434 (2013) doi:10.​1021/​Bc400166j CrossRef
21.214
P.M. Valencia, P.A. Basto, L.F. Zhang, M. Rhee, R. Langer, O.C. Farokhzad, R. Karnik: Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing, ACS Nano 4(3), 1671–1679 (2010)
21.215
M. Wang, M. Thanou: Targeting nanoparticles to cancer, Pharmacol. Res. 62(2), 90–99 (2010)
21.216
L. Zhang, F. Gu, J. Chan, A. Wang, R. Langer, O. Farokhzad: Nanoparticles in medicine: Therapeutic applications and developments, Clin. Pharmacol. Ther. 83(5), 761–769 (2008)
21.217
K.W. Spitzer, R.D. Vaughan-Jones: Regulation of intracellular pH in mammalian cells. In: The Sodium-Hydrogen Exchanger, ed. by M. Karmazyn, M. Arkiran, L. Fliegal (Springer, New York 2003) pp. 1–15
21.218
M. Stubbs, P.M. McSheehy, J.R. Griffiths, C.L. Bashford: Causes and consequences of tumour acidity and implications for treatment, Mol. Med. Today 6(1), 15–19 (2000)
21.219
K.E. Broaders, J.A. Cohen, T.T. Beaudette, E.M. Bachelder, J.M.J. Frechet: Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy, Proc. Natl. Acad. Sci. USA 106(14), 5497–5502 (2009)
21.220
E.M. Bachelder, T.T. Beaudette, K.E. Broaders, J.M.J. Frechet, M.T. Albrecht, A.J. Mateczun, K.M. Ainslie, J.T. Pesce, A.M. Keane-Myers: In vitro analysis of acetalated dextran microparticles as a potent delivery platform for vaccine adjuvants, Mol. Pharm. 7(3), 826–835 (2010)
21.221
M. Stockman: Nanoplasmonics: The physics behind the applications, Phys. Today 64(2), 39 (2011)
21.222
H. Wendt: Ullmann’s encyclopedia of industrial chemistry. In: Ullmann’s Encyclopedia of Industrial Chemistry, ‘‘Electrochemistry’’, ed. by H. Wendt (Wiley-VCH, Winheim 2004)
21.223
V. Dimitrova, L. Gorker: Modified Nernst equation for electroless metal deposition, Prog. React. Kinet. Mech. 31(1), 45–58 (2006)
21.224
D. Goia, E. Matijevic: Preparation of monodispersed metal particles, New J. Chem. 22, 1203–1215 (1998)
21.225
S. Yae, N. Nasu, K. Matsumoto, T. Hagihara, N. Fukumuro, H. Matsuda: Catalytic activity of noble metals for metal-assisted chemical etching of silicon, Electrochimica. Acta. 53, 35–41 (2007)
21.226
S. Yae, N. Nasu, K. Matsumoto, T. Hagihara, N. Fukumuro, H. Matsuda: Nucleation behavior in electroless displacement deposition of metals on silicon from hydrofluoric acid solutions, Electrochim. Acta. 53(1), 35–41 (2007)
21.227
K. Kneipp: Surface-enhanced Raman scattering, Phys. Today 60(11), 40–47 (2007)
21.228
M.L. Coluccio, F. Gentile, G. Das, A. Nicastri, A.M. Perri, P. Candeloro, G. Perozziello, R.P. Zaccaria, J.S.T. Gongora, S. Alrasheed, A. Fratalocchi, T. Limongi, G. Cuda, E. Di Fabrizio: Detection of single amino acid mutation in human breast cancer by disordered plasmonic self-similar chain, Sci. Adv. 1(8), e1500487 (2015)
21.229
F. Gentile, M. Coluccio, A. Toma, E. Rondanina, M. Leoncini, F. De Angelis, G. Das, C. Dorigoni, P. Candeloro, E. Di Fabrizio: Electroless deposition dynamics of silver nanoparticles clusters: A diffusion limited aggregation (DLA) approach, Microelectron. Eng. 98, 359–362 (2012)
21.230
R. Dawkins, D. ben-Avraham: Computer simulations of diffusion-limited reactions, Comput. Sci. Eng. 3(1), 72–76 (2001)
21.231
T. Qiu, P. Chu: Self-selective electroless plating: an approach for fabrication of functional 1-D nanomaterials, Mater. Sci. Eng. R 61, 59–77 (2008)
21.232
T. Qiu, X. Wu, Y. Mei, P. Chu, G. Siu: Self-organized synthesis of silver dendritic nanostructures via an electroless metal deposition method, Appl. Phys. A 81, 669–671 (2005)
21.233
T. Witten, L. Sander: Diffusion-limited aggregation, a kinetic critical phenomenon, Phys. Rev. Lett. 47(19), 1400–1403 (1981)
21.234
T. Witten, L. Sander: Diffusion-limited aggregation, Phys. Rev. B 27(9), 5686–5697 (1983)MathSciNet
21.235
M. Saltzmann: Drug Delivery (Oxford University Press, Oxford 2001)
21.236
P. Decuzzi, F. Gentile, A. Granaldi, A. Curcio, F. Causa, C. Indolfi, P. Netti, M. Ferrari: Flow chamber analysis of size effects in the adhesion of spherical particles, Int. J. Nanomed. 2(4), 689–696 (2007)
21.237
P. Meakin: Diffusion controlled deposition on surfaces: Cluster size distribution, interface exponents, and other properties, Phys. Rev. B 30(8), 4207–4214 (1984)
21.238
Z. Racz, T. Vicsek: Diffusion controlled deposition: Cluster statistics and scaling, Phys. Rev. Lett. 51(26), 2382–2385 (1983)
21.239
F. Gentile, E. Battista, A. Accardo, M. Coluccio, M. Asande, G. Perozziello, G. Das, C. Liberale, F. De Angelis, P. Candeloro, P. Decuzzi, E. Di Fabrizio: Fractal structure can explain the increased hydrophobicity of nanoporous silicon films, Microelectron. Eng. 88, 2537–2540 (2011)
21.240
F. Gentile, M.L. Coluccio, P. Candeloro, M. Barberio, G. Perozziello, M. Francardi, E. Di Fabrizio: Electroless deposition of metal nanoparticle clusters: Effect of pattern distance, J. Vacuum Sci. Technol. B 32(2), 031804 (2014)
21.241
G. Simone, N. Malara, V. Trunzo, M. Renne, G. Perozziello, E. Di Fabrizio, A. Manz: Galectin-3 coats the membrane of breast cells and makes a signature of tumours, Mol. Biosys. 10(2), 258–265 (2014)
21.242
G. Simone: An alternative approach to the phase change of proteins in an aqueous mixture with ethanol, Chem. Eng. Res. Design 105, 130–136 (2016)
21.243
G. Perozziello, R. La Rocca, G. Cojoc, C. Liberale, N. Malara, G. Simone, P. Candeloro, A. Anichini, L. Tirinato, F. Gentile, M.L. Coluccio, E. Carbone, E. Di Fabrizio: Microfluidic devices module tumor cell line susceptibility to NK cell recognition, Small 8(18), 2886–2894 (2012)
21.244
G. Perozziello, P. Candeloro, A. De Grazia, F. Esposito, M. Allione, M.L. Coluccio, R. Tallerico, I. Valpapuram, L. Tirinato, G. Das, A. Giugni, B. Torre, P. Veltri, U. Kruhne, G.D. Valle, E. Di Fabrizio: Microfluidic device for continuous single cells analysis via Raman spectroscopy enhanced by integrated plasmonic nanodimers, Opt. Express 24(2), A180–A190 (2016)
21.245
G. Simone: Demonstrating microdroplet coalescence for tailored and biodegradable microgel fabrication, RSC Adv. 5(70), 56848–56854 (2015)
21.246
G. Simone: Micro analysis to map the glycome code, Proteomics 14(9), 994–1000 (2014)
21.247
R. Catalano, G. Perozziello, G. Simone, P. Candeloro, F. Gentile, M.L. Coluccio, F. Pardeo, M. Burghammer, G. Cuda, C. Riekel, E. Di Fabrizio: Optimized fabrication protocols of microfluidic devices for x-ray analysis, Microelectron. Eng. 124, 13–16 (2014)
21.248
G. Keramas, G. Perozziello, O. Geschke, C.B.V. Christensen: Development of a multiplex microarray microsystem, Lab Chip 4(2), 152–158 (2004)
21.249
G. Perozziello, P. Candeloro, F. Gentile, A. Nicastri, A.M. Perri, M.L. Coluccio, E. Parrotta, A. De Grazia, M. Tallerico, F. Pardeo, R. Catalano, G. Cuda, E. Di Fabrizio: A microfluidic dialysis device for complex biological mixture SERS analysis, Microelectron. Eng. 144, 37–41 (2015)
21.250
G. Simone, N. Malara, V. Trunzo, G. Perozziello, P. Neuzil, M. Francardi, L. Roveda, M. Renne, U. Prati, V. Mollace, A. Manz, E. Di Fabrizio: Protein–carbohydrate complex reveals circulating metastatic cells in a microfluidic assay, Small 9(12), 2152–2161 (2013)
21.251
G. Perozziello, P. Candeloro, F. Gentile, A. Nicastri, A. Perri, M.L. Coluccio, A. Adamo, F. Pardeo, R. Catalano, E. Parrotta, H.D. Espinosa, G. Cuda, E. Di Fabrizio: Microfluidics and nanotechnology: Towards fully integrated analytical devices for the detection of cancer biomarkers, RSC Adv. 4(98), 55590–55598 (2014)
21.252
G. Perozziello, R. Catalano, M. Francardi, E. Rondanina, F. Pardeo, F. De Angelis, N. Malara, P. Candeloro, G. Morrone, E. Di Fabrizio: A microfluidic device integrating plasmonic nanodevices for Raman spectroscopy analysis on trapped single living cells, Microelectron. Eng. 111, 314–319 (2013)
21.253
G. Perozziello, J. Møllenbach, S. Laursen, E. di Fabrizio, K. Gernaey, U. Krühne: Lab on a chip automates in vitro cell culturing, Microelectron. Eng. 98, 655–658 (2012)
21.254
G. Simone, G. Perozziello: UV/VIS transparent optical waveguides fabricated using organic–inorganic nanocomposite layers, J. Nanosci. Nanotechnol. 11, 2057–2063 (2011)
21.255
F. De Angelis, F. Gentile, F. Mecarini, G. Das, M. Moretti, P. Candeloro, M.L. Coluccio, G. Cojoc, A. Accardo, C. Liberale, R.P. Zaccaria, G. Perozziello, L. Tirinato, A. Toma, G. Cuda, R. Cingolani, E. Di Fabrizio: Breaking the diffusion limit with super-hydrophobic delivery of molecules to plasmonic nanofocusing SERS structures, Nature Photonics 5, 682–687 (2011)
Metadaten
Titel
Nano-Particles for Biomedical Applications
verfasst von
Paolo Decuzzi
Alessandro Coclite
Aeju Lee
Anna Lisa Palange
Daniele Di Mascolo
Ciro Chiappini
Hélder A. Santos
Maria Laura Coluccio
Gerardo Perozziello
Patrizio Candeloro
Enzo Di Fabrizio
Francesco Gentile
Copyright-Jahr
2017
Verlag
Springer Berlin Heidelberg
Buch
Springer Handbook of Nanotechnology

Print ISBN: 978-3-662-54355-9

Electronic ISBN: 978-3-662-54357-3

Copyright-Jahr: 2017

DOI
https://doi.org/10.1007/978-3-662-54357-3_21

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