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Erschienen in:
1993 | OriginalPaper | Buchkapitel
Nonlinear Synaptic Integration in Neostriatal Spiny Neurons
verfasst von : Charles J. Wilson
Erschienen in: Neural Systems: Analysis and Modeling
Verlag: Springer US
Enthalten in: Professional Book Archive
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The presence of a variety of voltage-gated channels which are activated at subthreshold membrane potentials increases the complexity of the computations that can be expected from individual neurons. This is especially so for neurons receiving large numbers of relatively weak synaptic inputs so that many spatially distributed inputs are required to excite each cell. In a model of one such neuron the spiny projection cell of the mammalian neostriatum inclusion of a simple and very common membrane nonlinearity the time-independent inwardly rectifying potassium conductance caused spatially distributed weak synapses to summate cooperatively while having no effect on the integration of spatially clustered synaptic input.