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Journal of Polymer Research

Erschienen in:

01.01.2019 | ORIGINAL PAPER

Preparation and characterization of sustained release system based on polyanhydride microspheres with core/shell-like structures

verfasst von: I-Ming Chu, Tsang-Hao Liu, Yu-Ru Chen

Erschienen in: Journal of Polymer Research | Ausgabe 1/2019

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Abstract

A system for localized drug delivery composed of polyanhydride polymers was studied. The polymers were made via melt-condensation of sebacic acid (SA) with different amount of 1, 3-bis (p-carboxyphenoxy) propane (CPP) as copolymers. By double emulsion technique, microspheres with core/shell-like structure were fabricated. Hydrophilic compound Brilliant Blue G (BBG) was encapsulated in the inner core(s) region with loading efficiencies of 50% ~ 60% for poly (SA) and 40% ~ 45% for poly(SA-CPP) copolymer. Hydrophobic compound, curcumin, was encapsulated in the outer shell region at efficiencies about 90%. Drug release profiles show no initial burst and stable release rates. The studied delivery system was showed to provide stable release for both hydrophilic and hydrophobic compounds simultaneously.

Nächster Artikel Synthesis and characterization of thianthrene-containing preimidized soluble polyimide resins and the derived films with high refractive indices and good optical transparency

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Titel: Preparation and characterization of sustained release system based on polyanhydride microspheres with core/shell-like structures
verfasst von: I-Ming Chu
Tsang-Hao Liu
Yu-Ru Chen
Publikationsdatum: 01.01.2019
Verlag: Springer Netherlands
Erschienen in: Journal of Polymer Research / Ausgabe 1/2019
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-018-1657-5

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