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Erschienen in:
2015 | OriginalPaper | Buchkapitel
Real Time Measurement of Dopamine Releasing under Optogenetic Stimulation
verfasst von : Cho-Han Hsieh, Chun-Wei Wu, Meng-Chun Liu, Jia-Jin Jason Chen
Erschienen in: 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering
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Dopamine (DA) is a neurotransmitter involved in controlling of fine movement, which is deficient in Parkinson’s disease (PD). Measurement of DA is an urgent need concerning the development of PD therapy. We’ve developed a fastscan cyclic voltammetry (FSCV) for real time measurement of dopamine releasing in dopaminergic SH-SY5Y cells under tissue-specific optogenetic stimulation. With the novel cellular optical-induced DA-releasing model, the performance of FSCV will be validated under various stimulating parameters.