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Erschienen in:

2016 | OriginalPaper | Buchkapitel

Recent Advances in Chitosan-Based Nanomedicines for Cancer Chemotherapy

verfasst von : Ankit Saneja, Chetan Nehate, Noor Alam, Prem N. Gupta

Erschienen in: Chitin and Chitosan for Regenerative Medicine

Verlag: Springer India

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Abstract

Chitosan, a cationic polysaccharide, has prompted the continuous impetus for the development of tumor targeted drug delivery systems, thanks to the polymer’s biocompatibility, low toxicity, and biodegradability. The presence of primary hydroxyl and amine groups on its backbone allows it for chemical modifications to control its physical properties. The nanomedicines prepared from chitosan and its derivatives can be delivered through different routes, such as oral, intravenous, and intraperitoneal. Chitosan-based nanomedicines including nanoparticles, microspheres, drug conjugates, micelles, hydrogels, etc. are in various stages of development. This polymer is being currently investigated for simultaneous delivery of two chemotherapeutic agents or chemotherapeutic agent with a gene carrier to produce synergistic effects. This chapter summarizes the recent advances in application of chitosan and its derivatives as a carrier for chemotherapeutic agents as well as gene carriers for cancer chemotherapeutics.

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Vorheriges Kapitel Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Nächstes Kapitel Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

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Titel: Recent Advances in Chitosan-Based Nanomedicines for Cancer Chemotherapy
verfasst von: Ankit Saneja
Chetan Nehate
Noor Alam
Prem N. Gupta
Verlag: Springer India
Buch: Chitin and Chitosan for Regenerative Medicine
Print ISBN: 978-81-322-2510-2

Electronic ISBN: 978-81-322-2511-9

Copyright-Jahr: 2016
DOI: https://doi.org/10.1007/978-81-322-2511-9_9

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