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Erschienen in: Advances in Data Analysis and Classification 1/2013

01.03.2013 | Regular Article

Regularized logistic discrimination with basis expansions for the early detection of Alzheimer’s disease based on three-dimensional MRI data

verfasst von: Yuko Araki, Atsushi Kawaguchi, Fumio Yamashita

Erschienen in: Advances in Data Analysis and Classification | Ausgabe 1/2013

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Abstract

In recent years, evidence has emerged indicating that magnetic resonance imaging (MRI) brain scans provide valuable diagnostic information about Alzheimer’s disease. It has been shown that MRI brain scans are capable of both diagnosing Alzheimer’s disease itself at an early stage and identifying people at risk of developing Alzheimer’s. In this article, we have investigated statistical methods for classifying Alzheimer’s disease patients based on three-dimensional MRI data via L2-type regularized logistic discrimination with basis expansions. Preceding studies adopted an open approach when applying three-dimensional data analysis. Our proposed classification model with dimension reduction techniques offers discriminant functions with excellent prediction performance in terms of sensitivity and specificity.

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Metadaten
Titel
Regularized logistic discrimination with basis expansions for the early detection of Alzheimer’s disease based on three-dimensional MRI data
verfasst von
Yuko Araki
Atsushi Kawaguchi
Fumio Yamashita
Publikationsdatum
01.03.2013
Verlag
Springer-Verlag
Erschienen in
Advances in Data Analysis and Classification / Ausgabe 1/2013
Print ISSN: 1862-5347
Elektronische ISSN: 1862-5355
DOI
https://doi.org/10.1007/s11634-013-0127-5

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