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2017 | OriginalPaper | Buchkapitel

Statistical Abstraction for Multi-scale Spatio-Temporal Systems

verfasst von : Michalis Michaelides, Jane Hillston, Guido Sanguinetti

Erschienen in: Quantitative Evaluation of Systems

Verlag: Springer International Publishing

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Abstract

Spatio-temporal systems exhibiting multi-scale behaviour are common in applications ranging from cyber-physical systems to systems biology, yet they present formidable challenges for computational modelling and analysis. Here we consider a prototypic scenario where spatially distributed agents decide their movement based on external inputs and a fast-equilibrating internal computation. We propose a generally applicable strategy based on statistically abstracting the internal system using Gaussian Processes, a powerful class of non-parametric regression techniques from Bayesian Machine Learning. We show on a running example of bacterial chemotaxis that this approach leads to accurate and much faster simulations in a variety of scenarios.

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Fußnoten
1
The pCTMC is the internal model for a single agent here, not for multiple agents.
 
2
It is highly unlikely to have more than a single transition since (mL) are continuous values that constantly change for the bacterium.
 
3
We sub-sample because the KS test p-value depends heavily on sample size. Even if two distributions generating samples might be very close, in the limit of an infinite sample size one approaches the true distributions. In such a case, the KS test will reject that the two samples were produced by the same distribution, returning lower p-values as sample size increases (for the same KS distance). We do not expect to produce the same distributions here since we are making approximations, so comparing p-values for very large sample sizes is not of interest.
 
Literatur
1.
Zurück zum Zitat Bortolussi, L., Milios, D., Sanguinetti, G.: Efficient stochastic simulation of systems with multiple time scales via statistical abstraction. In: Roux, O., Bourdon, J. (eds.) CMSB 2015. LNCS, vol. 9308, pp. 40–51. Springer, Cham (2015). doi:10.1007/978-3-319-23401-4_5 CrossRef Bortolussi, L., Milios, D., Sanguinetti, G.: Efficient stochastic simulation of systems with multiple time scales via statistical abstraction. In: Roux, O., Bourdon, J. (eds.) CMSB 2015. LNCS, vol. 9308, pp. 40–51. Springer, Cham (2015). doi:10.​1007/​978-3-319-23401-4_​5 CrossRef
2.
Zurück zum Zitat Bortolussi, L., Milios, D., Sanguinetti, G.: Smoothed model checking for uncertain continuous-time Markov chains. Inf. Comput. 247, 235–253 (2016)MathSciNetCrossRefMATH Bortolussi, L., Milios, D., Sanguinetti, G.: Smoothed model checking for uncertain continuous-time Markov chains. Inf. Comput. 247, 235–253 (2016)MathSciNetCrossRefMATH
3.
Zurück zum Zitat Chakravarty, I.M., Laha, R.G., Roy, J.D.: Handbook of Methods of Applied Statistics. McGraw-Hill, New York (1967) Chakravarty, I.M., Laha, R.G., Roy, J.D.: Handbook of Methods of Applied Statistics. McGraw-Hill, New York (1967)
4.
Zurück zum Zitat Dada, J.O., Mendes, P.: Multi-scale modelling and simulation in systems biology. Integr. Biol. 3(2), 86 (2011)CrossRef Dada, J.O., Mendes, P.: Multi-scale modelling and simulation in systems biology. Integr. Biol. 3(2), 86 (2011)CrossRef
5.
Zurück zum Zitat Frankel, N.W., Pontius, W., Dufour, Y.S., Long, J., Hernandez-Nunez, L., Emonet, T.: Adaptability of non-genetic diversity in bacterial chemotaxis. eLife 3, e03526 (2014)CrossRef Frankel, N.W., Pontius, W., Dufour, Y.S., Long, J., Hernandez-Nunez, L., Emonet, T.: Adaptability of non-genetic diversity in bacterial chemotaxis. eLife 3, e03526 (2014)CrossRef
6.
Zurück zum Zitat Gilbert, D., Heiner, M., Takahashi, K., Uhrmacher, A.M.: Multiscale Spatial Computational Systems Biology (Dagstuhl Seminar 14481) (2015) Gilbert, D., Heiner, M., Takahashi, K., Uhrmacher, A.M.: Multiscale Spatial Computational Systems Biology (Dagstuhl Seminar 14481) (2015)
7.
Zurück zum Zitat Gillespie, D.T.: Exact stochastic simulation of coupled chemical reactions. J. Phys. Chem. 81(25), 2340–2361 (1977)CrossRef Gillespie, D.T.: Exact stochastic simulation of coupled chemical reactions. J. Phys. Chem. 81(25), 2340–2361 (1977)CrossRef
8.
Zurück zum Zitat Goutsias, J.: Quasiequilibrium approximation of fast reaction kinetics in stochastic biochemical systems. J. Chem. Phys. 122(18), 184102 (2005)CrossRef Goutsias, J.: Quasiequilibrium approximation of fast reaction kinetics in stochastic biochemical systems. J. Chem. Phys. 122(18), 184102 (2005)CrossRef
9.
Zurück zum Zitat Hansen, C.H., Endres, R., Wingreen, N.: Chemotaxis in Escherichia coli: a molecular model for robust precise adaptation. PLoS Comput. Biol. 4(1), e1 (2008)MathSciNetCrossRef Hansen, C.H., Endres, R., Wingreen, N.: Chemotaxis in Escherichia coli: a molecular model for robust precise adaptation. PLoS Comput. Biol. 4(1), e1 (2008)MathSciNetCrossRef
10.
Zurück zum Zitat Haseltine, E.L., Rawlings, J.B.: Approximate simulation of coupled fast and slow reactions for stochastic chemical kinetics. J. Chem. Phys. 117(15), 6959–6969 (2002)CrossRef Haseltine, E.L., Rawlings, J.B.: Approximate simulation of coupled fast and slow reactions for stochastic chemical kinetics. J. Chem. Phys. 117(15), 6959–6969 (2002)CrossRef
11.
Zurück zum Zitat Michaelides, M., Milios, D., Hillston, J., Sanguinetti, G.: Property-driven state-space coarsening for continuous time Markov chains. In: Agha, G., Houdt, B. (eds.) QEST 2016. LNCS, vol. 9826, pp. 3–18. Springer, Cham (2016). doi:10.1007/978-3-319-43425-4_1 CrossRef Michaelides, M., Milios, D., Hillston, J., Sanguinetti, G.: Property-driven state-space coarsening for continuous time Markov chains. In: Agha, G., Houdt, B. (eds.) QEST 2016. LNCS, vol. 9826, pp. 3–18. Springer, Cham (2016). doi:10.​1007/​978-3-319-43425-4_​1 CrossRef
12.
Zurück zum Zitat Norris, J.R.: Markov Chains. Cambridge University Press, Cambridge (1998)MATH Norris, J.R.: Markov Chains. Cambridge University Press, Cambridge (1998)MATH
13.
Zurück zum Zitat Rao, C.V., Arkin, A.P.: Stochastic chemical kinetics and the quasi-steady-state assumption: application to the Gillespie algorithm. J. Chem. Phys. 118(11), 4999–5010 (2003)CrossRef Rao, C.V., Arkin, A.P.: Stochastic chemical kinetics and the quasi-steady-state assumption: application to the Gillespie algorithm. J. Chem. Phys. 118(11), 4999–5010 (2003)CrossRef
14.
Zurück zum Zitat Rasmussen, C.E., Williams, C.K.I.: Gaussian Processes for Machine Learning. Adaptive Computation and Machine Learning. MIT Press, Cambridge (2006)MATH Rasmussen, C.E., Williams, C.K.I.: Gaussian Processes for Machine Learning. Adaptive Computation and Machine Learning. MIT Press, Cambridge (2006)MATH
15.
Zurück zum Zitat Sneddon, M.W., Pontius, W., Emonet, T.: Stochastic coordination of multiple actuators reduces latency and improves chemotactic response in bacteria. PNAS 109(3), 805–810 (2012)CrossRef Sneddon, M.W., Pontius, W., Emonet, T.: Stochastic coordination of multiple actuators reduces latency and improves chemotactic response in bacteria. PNAS 109(3), 805–810 (2012)CrossRef
16.
Zurück zum Zitat Snelson, E., Ghahramani, Z.: Sparse Gaussian processes using pseudo-inputs. In: Weiss, Y., Schlkopf, P.B., Platt, J.C. (eds.) Advances in Neural Information Processing Systems 18, pp. 1257–1264. MIT Press, Cambridge (2006) Snelson, E., Ghahramani, Z.: Sparse Gaussian processes using pseudo-inputs. In: Weiss, Y., Schlkopf, P.B., Platt, J.C. (eds.) Advances in Neural Information Processing Systems 18, pp. 1257–1264. MIT Press, Cambridge (2006)
17.
Zurück zum Zitat Sourjik, V., Berg, H.C.: Functional interactions between receptors in bacterial chemotaxis. Nature 428(6981), 437–441 (2004)CrossRef Sourjik, V., Berg, H.C.: Functional interactions between receptors in bacterial chemotaxis. Nature 428(6981), 437–441 (2004)CrossRef
18.
Zurück zum Zitat Sourjik, V., Wingreen, N.S.: Responding to chemical gradients: bacterial chemotaxis. Curr. Opin. Cell Biol. 24(2), 262–268 (2012)CrossRef Sourjik, V., Wingreen, N.S.: Responding to chemical gradients: bacterial chemotaxis. Curr. Opin. Cell Biol. 24(2), 262–268 (2012)CrossRef
19.
Zurück zum Zitat Vladimirov, N., Lebiedz, D., Sourjik, V.: Predicted auxiliary navigation mechanism of peritrichously flagellated chemotactic bacteria. PLoS Comput. Biol. 6(3), e1000717 (2010)MathSciNetCrossRef Vladimirov, N., Lebiedz, D., Sourjik, V.: Predicted auxiliary navigation mechanism of peritrichously flagellated chemotactic bacteria. PLoS Comput. Biol. 6(3), e1000717 (2010)MathSciNetCrossRef
20.
Zurück zum Zitat Vladimirov, N., Lvdok, L., Lebiedz, D., Sourjik, V.: Dependence of bacterial chemotaxis on gradient shape and adaptation rate. PLoS Comput. Biol. 4(12), e1000242 (2008)CrossRef Vladimirov, N., Lvdok, L., Lebiedz, D., Sourjik, V.: Dependence of bacterial chemotaxis on gradient shape and adaptation rate. PLoS Comput. Biol. 4(12), e1000242 (2008)CrossRef
Metadaten
Titel
Statistical Abstraction for Multi-scale Spatio-Temporal Systems
verfasst von
Michalis Michaelides
Jane Hillston
Guido Sanguinetti
Copyright-Jahr
2017
DOI
https://doi.org/10.1007/978-3-319-66335-7_15

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