Study the Impact of the SH-SY5Y Cells under the Magnetic Stimulation with Different Frequency and Duration

Repetitive transcranial magnetic stimulation (rTMS), which is produced by strong non-static magnetic fields, is an non-invasive means to stimulate the cerebral cortex. The recent studies show that rTMS affects treatment parkinson’s dieses and improves motor symptoms in patients. However, the relationship between the clinical efficacy of rTMS and mechanism is still obscure. In this study we have investigated the effects of different stimulation frequencies and number of treatments on dopamine secretion and neural functions in SH-SY5Y cell cultures. A repetitive session of magnetic stimulation with no matter high or low frequency, intracellular ROS were decreased. In the same time, neurons after magnetic stimulation will release neurotransmitters. These results suggest a possible use of this particular physical stimulation to improve the functional capability of the cells to face oxidative stress. Based on our study we can more understand that the effect of repetitive transcranial magnetic stimulations (rTMS) on Parkinson’s disease.