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Erschienen in:

2019 | OriginalPaper | Buchkapitel

Synthesis and Characterization of PVP/CaCO₃-Ag Blend Hydrogel by Gamma Irradiation: Study of Drug Delivery System and Antimicrobial Activity

verfasst von : Angelica Tamiao Zafalon, Vinícius dos Santos Juvino, Luiz Gustavo Hiroki Komatsu, Duclerc Fernandes Parra, Ademar Lugao, Temesgen Samuel, Vijaya Rangari

Erschienen in: Characterization of Minerals, Metals, and Materials 2019

Verlag: Springer International Publishing

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Abstract

Chronic wounds are skin injuries with failed healing. They have become a public health problem that affects more than 2% of the population and the presence of bacteria resistances difficult of treatment. Pseudomonas aeruginosa is opportunist pathogens and the treatment is difficult and requires a long period of treatment. Hydrogels are structure polymeric tridimensional and biocompatible. They have been used as a controlled delivery system for treatment of topic infection. Studies have reported calcium carbonate and silver ion can improve the mechanical properties and biocide activity of hydrogel. Here in this study, hydrogels loaded CaCO₃-Ag were prepared using poly (N-vinyl-2-pyrrolidone), poly (ethylene glycol), agar, calcium carbonate, silver nitrate followed gamma irradiation with 25 kGy dose. The gel fraction, behavior swelling and biocide action against P. aeruginosa was investigated. The degree of swelling of the hydrogel loaded CaCO₃-Ag was 12% higher than the unloaded and exhibited antibacterial effects against P. aeruginosa and biofilm.

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Resmi R, Unnikrishnan S, Krishan LK, Krishnan VK (2017) Synthesis and characterization of silver nanoparticle incorporated gelatin-hydroxypropyl methacrylate hydrogels for wound dressing applications. J Appl Polym Sci. https://doi.org/10.1002/app.44529

Annabi N, Rana D, Sani ES, Portillo-Lara R, Gifford JL, Fares MM, Mithieux SM, Weiss AS (2017) Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing. Biomater 139:229–243CrossRef

Mostafa M, Choonara YE, Marimuthu T, Kumar P, Toit LC, Vuuren SV, Pillay V (2017) Ca3(PO4)2 precipitated layering of an in situ hybridized PVA/Ca2O4Si nanofibrous antibacterial wound dressing. Int J Pharm 507:41–49

Konstantinow A, Fischer T, Ring J (2016) Effectiveness of collagen/oxidised regenerated cellulose/silver-containing composite wound dressing for the treatment of medium-depth split-thickness skin graft donor site wounds in multi-morbid patients: a prospective, non-comparative, single-centre study. Int Wound J 14(5):791–800CrossRef

Bhowmick S, Koul V (2016) Assessment of PVA/silver nanocomposite hydrogel patch as antimicrobial dressing scaffold: synthesis, characterization and biological evaluation. Mat Sci Eng C 59:109–119CrossRef

Lane DD, Fessler AK, Goo S, Williams DL, Stewart RJ (2016) Sustained tobramycin release from polyphosphate double network hydrogels. Acta Biomater 50:484–492CrossRef

Catanzano O, D’esposito V, Pulcrano G, Maiolino S, Ambrosio MR, Esposito M, Miro A, Ungaro F, Formisano P, Catania MR, Quaglia F (2017) Ultra-small silver nanoparticles loaded in alginate-hyaluronic acid hybrid hydrogels for treating infected wounds. Int J Polym Mater Po 66(12):626–634CrossRef

Khan ST, Musarraf J, Al-Khedhairy AA (2016) Countering drug resistance, infectious diseases, and sepsis using metal and metal oxides nanoparticles: current status. Colloids Surf B Biointerfaces 146:70–83CrossRef

McMahon S, Kennedy R, Duffy P, Vasquez JM, Wall JG, Tai H, Wang W (2016) Poly (ethylene glycol) based hyperbranched polymer from RAFT and its application as a silver sulfadiazine loaded anti-bacterial hydrogel in wound care. ACS Appl Mater Interfaces 8(4):26648–26656CrossRef

10.

Naik K, Kowshik M (2017) The silver lining: towards the responsible and limited usage of silver. J Appl Microbiol 123:1068–1087CrossRef

11.

Zafalon AT, Santos VJ, Lugao AB, Rangari V, Samuel T, Parra DF (2018) Stability of the neomycin antibiotic in irradiated polymeric biomaterials. Eur J Biomed Pharm 5(7):49–57

12.

Singh D, Singh A, Singh R (2015) Polyvinyl pyrrolidone/carrageenan blend hydrogels with nanosilver prepared by gamma radiation for use as an antimicrobial wound dressing. J Biomater Sci Polym Ed 26:1269–1285CrossRef

13.

Park JY, Kyung KH, Tsukada K, Kim SH, Shiratori S (2017) Biodegradable polycaprolactone nanofibres with β-chitosan and calcium carbonate produce a hemostatic effect. Polym 123:194–202CrossRef

14.

Sambudi NS, Park SB, Cho K (2016) Enhancing the mechanical properties of electrospun chitosan/poly(vinyl alcohol) fibers by mineralization with calcium carbonate. J Mater Sci 51:7742–7753CrossRef

15.

Dutra JAP, Carvalho SG, Zampirolli ACD, Daltoe RD, Teixeira RM, Careta FP, Cotrim MAP, Orefice RL, Villanoca JCO (2016) Papain wound dressings obtained from poly(vinyl alcohol)/calcium alginate blends as new pharmaceutical dosage form: preparation and preliminary evaluation. Eur J Pharm Biopharm 113:11–23CrossRef

16.

Wu HL, Hou XX, Branford-White C, Sun XZ, Um-I-Zahra S, Zhu LM (2015) Drug-loaded microparticles prepared by the one-step deposition of calcium carbonate/alginate onto cotton fabrics. J Appl Polym Sci 42618:1–8

17.

Apalangyaa V, Rangari V, Tiimoba B, Jeelani S, Samuel T (2014) Development of antimicrobial water filtration hybrid material from bio source calcium carbonate and silver nanoparticles. Appl Surf Sci 295:108–114CrossRef

18.

Kilic AG, Malci S, Çelikbiçak O, Sahiner N, Salih B (2005) Gold recovery onto poly(acrylamide-allylthiourea) hydrogels synthesized by treating with gamma radiation. Anal Chim Acta 547:18–25CrossRef

19.

Lugao AB, Rogero SO, Malmonge SM (2002) Rheological behaviour of irradiated wound dressing poly(vinyl pyrrolidone) hydrogels. Radiat Phys Chem 63:543–546CrossRef

20.

Ajji Z, Othman I, Rosiak JM (1995) Production of hydrogel wound dressings using gamma radiation. Nucl Int Methds Phys Res 229:375–380CrossRef

21.

Sood S, Gupta VK, Agarwal S, Dev K, Pathania D (2017) Controlled release of antibiotic amoxicillin drug using carboxymethyl cellulose-cl-poly(itaconic acid-co-lactic acid) hydrogel. Int Biol Macromol 101:612–620CrossRef

22.

Rosiak JM, Ulanski P, Pajewski LA, Yoshi F, Makuuchi K (1995) Radiation formationof hydrogels for biomedical purposes some remarks and comments. Radiat Phys Chem 46:161–168CrossRef

23.

Peppas NA, Bures P, Leobandung W, Ichikawa H (2000) Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50:27–46CrossRef

24.

Oliani WL, Parra DF, Komatsu LGH, Lincopan N, Rangari VK, Lugao AB (2017) Fabrication of polypropylene/silver nanocomposites for biocidal applications. Mater Sci Eng, C 75:845–853CrossRef

25.

Norris P, Noble M, Francolini I, Vinogradov AM, Stewart PS, Ratner BD, Costerton JW, Stodley P (2005) Ultrasonically controlled release of ciprofloxacin from self-assembled coatings on poly(2-hydroxyethyl methacrylate) hydrogels for Pseudomonas aeruginosa biofilm prevention. Antimicrob Agents Chemother 49(10):4272–4279CrossRef

26.

Hoekstra MJ, Westgate SJ, Muleer S (2016) Povidone-iodine ointment demonstrates in vitro efficacy against biofilm formation. Int Wound J 14(1):172–179CrossRef

27.

Metcalf DG, Parsons D, Bowler P (2016) Clinical safety and effectiveness evaluation of a new antimicrobial wound dressing designed to manage exudate, infection and biofilm. Int Wound J 14(1):203–213CrossRef

28.

Ortega-Pena S, Hidalgo-Gonzalez C, Robson MC, Krotzsch E (2016) In vitro microbicidal, anti-biofilm and cytotoxic effects of different commercial antiseptics. Int Wound J 14(3):470–479CrossRef

Titel: Synthesis and Characterization of PVP/CaCO3-Ag Blend Hydrogel by Gamma Irradiation: Study of Drug Delivery System and Antimicrobial Activity
verfasst von: Angelica Tamiao Zafalon
Vinícius dos Santos Juvino
Luiz Gustavo Hiroki Komatsu
Duclerc Fernandes Parra
Ademar Lugao
Temesgen Samuel
Vijaya Rangari
Verlag: Springer International Publishing
Buch: Characterization of Minerals, Metals, and Materials 2019
Print ISBN: 978-3-030-05748-0

Electronic ISBN: 978-3-030-05749-7

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-3-030-05749-7_26

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