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Journal of Materials Science
Erschienen in: Journal of Materials Science 18/2018

18.06.2018 | Biomaterials

Synthesis of a carbon dioxide-based amphiphilic block copolymer and its evaluation as a nanodrug carrier

verfasst von: Hongchun Li, Lulu Sui, Yongsheng Niu

Erschienen in: Journal of Materials Science | Ausgabe 18/2018

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Abstract

A series of novel amphiphilic block copolymers poly(propylene carbonate)-block-mono-methoxy poly(ethylene oxide) (PPC-b-MPEG) composed of hydrophobic PPC segments and various lengths of hydrophilic MPEG segments was synthesized via “Click Chemistry” between azido-terminated PPC and alkynyl-terminated MPEG. The structure of the copolymers was characterized by FTIR, 1H NMR and 13C NHR techniques. Chlorpyrifos (CHP) was encapsulated within micelles through diffusion dialysis method, leading to the formation of CHP-loaded PPC-b-MPEG micelles. The resulting micelles were characterized further by dynamic light scattering (DLS) and scanning electron microscope. The results indicated that PPC-b-MPEG could self-assemble into nanosized micelles with PPC cores and PEG shells in aqueous solution. And the size, zeta potential, morphology, critical micelle concentration of PPC-b-MPEG micelles can be altered by changing the lengths of the PEG segments. CHP was encapsulated into PPC-b-MPEG2k micelles with loading capacity of 9.02% and entrapment efficiency of 77.28%. These results suggested that PPC-b-MPEG micelles would be a potential carrier for controlled release.
Vorheriger Artikel Moisture-triggered release of self-produced ClO2 gas from microcapsule antibacterial film system
Nächster Artikel Converting waste coal fly ash into effective adsorbent for the removal of ammonia nitrogen in water

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Metadaten
Titel
Synthesis of a carbon dioxide-based amphiphilic block copolymer and its evaluation as a nanodrug carrier
verfasst von
Hongchun Li
Lulu Sui
Yongsheng Niu
Publikationsdatum
18.06.2018
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 18/2018
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-2594-8

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