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01.04.2023 | Research paper

Synthesis of Au nanoparticles coated with silica containing polyethylene glycol for extracorporeally dischargeable X-ray contrast agents

verfasst von: Takeru Sakamoto, Noriko Yamauchi, Shohei Tada, Takumu Takase, Mone Kimura, Chihiro Nishidate, Kohsuke Gonda, Yoshio Kobayashi

Erschienen in: Journal of Nanoparticle Research | Ausgabe 4/2023

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Abstract

This work proposes a method for fabricating nanoparticles composed of gold (Au) nanoparticles and silica shells containing polyethylene glycol (PEG) (Au/SiO₂(PEG)) for diagnostic imaging. The proposed method involves two steps. The first step is the synthesis of Au nanoparticles. The synthesis of Au nanoparticles with a diameter of 2.2 ± 0.4 nm was performed with a reduction of hydrogentetrachloroaurate (III) trihydrate with tetrakis (hydroxymethyl) phosphonium chloride in a sodium hydroxide (NaOH) aqueous solution. In the second step, the Au nanoparticles are coated in silica while in the presence of PEG. The silica coating was produced by a sol–gel reaction of tetraethylorthosilicate in the presence of Au nanoparticles and PEG in water/ethanol dissolving NaOH. The Au/SiO₂(PEG) nanoparticles degraded faster and in larger quantities in bovine calf serum/phosphate-buffered saline solution than silica-coated Au nanoparticles fabricated in the absence of PEG and had an X-ray imaging ability.

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Vorheriger Artikel Synthesis and photocatalytic activity of EuBO3 photocatalyst with different morphological characteristics

Nächster Artikel Facile synthesis of Fe3O4 nanoparticles at room temperature coated with meso-2,3-dimercaptosuccinic acid for improved biocompatibility

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Titel: Synthesis of Au nanoparticles coated with silica containing polyethylene glycol for extracorporeally dischargeable X-ray contrast agents
verfasst von: Takeru Sakamoto
Noriko Yamauchi
Shohei Tada
Takumu Takase
Mone Kimura
Chihiro Nishidate
Kohsuke Gonda
Yoshio Kobayashi
Publikationsdatum: 01.04.2023
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 4/2023
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-023-05726-1

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