The Biochemical Effects of Citrinin: A Review

The implication of citrinin by Krogh et al. (1973) as one of the causative agents of Balkan porcine necropathy stimulated a number of workers to initiate studies of the biochemical effects of this mycotoxin. Much of the work involved in vitro measurements carried out with tissue slices or with cell cultures. In many of the earlier studies, various doses of citrinin were administered to the test animals and measurements were made in vivo or on tissues removed from the animal. In subsequent studies, the exposure to the tissue has been carried out in vitro together with the measurement of the effect.