Erschienen in:

2001 | OriginalPaper | Buchkapitel

Waveguide Fluorosensor for the Detection of Ligand-Receptor Interactions

The 5-HT3 Serotonin Receptor

verfasst von : Evelyne L. Schmid, Ruud Hovius, Michael Pawlak, Markus Ehrat, Horst Vogel

Erschienen in: Novel Approaches in Biosensors and Rapid Diagnostic Assays

Verlag: Springer US

Enthalten in: Professional Book Archive

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A highly-sensitive surface fluorescence technique was combined with a powerful method for the oriented reversible immobilization of membrane proteins on oxide surfaces. Affinity and kinetic parameters of the interaction of the receptor and a fluorescent ligand were evaluated. The approach is particularly suited for the study of rapid ligand-receptor interactions where optimized cell volume, flow and injection conditions are required.

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