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Erschienen in:
2009 | OriginalPaper | Buchkapitel
Whole-Genome Analysis of Gene Conversion Events
verfasst von : Chih-Hao Hsu, Yu Zhang, Ross Hardison, Webb Miller
Erschienen in: Comparative Genomics
Verlag: Springer Berlin Heidelberg
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Gene conversion events are often overlooked in analyses of genome evolution. In a conversion event, an interval of DNA sequence (not necessarily containing a gene) overwrites a highly similar sequence. The event creates relationships among genomic intervals that can confound attempts to identify orthologs and to transfer functional annotation between genomes. Here we examine 1,112,202 paralogous pairs of human genomic intervals, and detect conversion events in about 13.5% of them. Properties of the putative gene conversions are analyzed, such as the lengths of the paralogous pairs and the spacing between their sources and targets. Our approach is illustrated using conversion events in the beta-globin gene cluster.