2009 | OriginalPaper | Buchkapitel
A Cluster Overlap Measure for Comparison of Activations in fMRI Studies
verfasst von : Guillermo A. Cecchi, Rahul Garg, A. Ravishankar Rao
Erschienen in: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009
Verlag: Springer Berlin Heidelberg
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Most fMRI studies use voxel-wise statistics to carry out intra-subject as well as inter-subject analysis. We show that statistics derived from voxel-wise comparisons are likely to be noisy and error prone, especially for inter-subject comparisons. In this paper we propose a novel metric called
weighted cluster coverage
to compare two activation maps. This metric is based on the intersection of spatially contiguous clusters of activations. It is found to be more robust than voxel-wise comparisons and could potentially lead to more statistical power in fMRI-based group studies.