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2019 | OriginalPaper | Buchkapitel

A Framework for Calculating Time-Efficient Diffusion MRI Protocols for Anisotropic IVIM and An Application in the Placenta

verfasst von : Paddy J. Slator, Jana Hutter, Andrada Ianus, Eleftheria Panagiotaki, Mary A. Rutherford, Joseph V. Hajnal, Daniel C. Alexander

Erschienen in: Computational Diffusion MRI

Verlag: Springer International Publishing

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Abstract

We develop a framework for calculating clinically-viable diffusion MRI (dMRI) protocols for anisotropic IVIM modelling. The proposed multi-stage framework combines previous approaches to dMRI protocol optimisation: first optimising b-values by minimizing Cramer-Rao lower bounds on parameter variances, and subsequently optimising gradient directions jointly to provide maximum angular coverage across all shells. This removes unnecessary measurements of closely spaced b-values with the same gradient directions, which encode very similar information, and hence reduces the total number of dMRI measurements. We applied the framework to establish an organ-specific, data-driven, set of optimised b-values and gradient directions for dMRI of the placenta. The optimised protocol leads to higher contrast-to-noise ratios in parameter maps compared to a naive protocol of comparable scan time. Applying this framework in other organs has the potential to reduce scanning times required for anisotropic IVIM modelling.

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Vorheriges Kapitel Diffusion MRI Outside the Brain

Nächstes Kapitel Spatial Characterisation of Fibre Response Functions for Spherical Deconvolution in Multiple Sclerosis

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Titel: A Framework for Calculating Time-Efficient Diffusion MRI Protocols for Anisotropic IVIM and An Application in the Placenta
verfasst von: Paddy J. Slator
Jana Hutter
Andrada Ianus
Eleftheria Panagiotaki
Mary A. Rutherford
Joseph V. Hajnal
Daniel C. Alexander
Verlag: Springer International Publishing
Buch: Computational Diffusion MRI
Print ISBN: 978-3-030-05830-2

Electronic ISBN: 978-3-030-05831-9

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-3-030-05831-9_20

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