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Erschienen in:
2012 | OriginalPaper | Buchkapitel
A New Genetic Algorithm for Simplified Protein Structure Prediction
verfasst von : Mahmood A. Rashid, Md. Tamjidul Hoque, M. A. Hakim Newton, Duc Nghia Pham, Abdul Sattar
Erschienen in: AI 2012: Advances in Artificial Intelligence
Verlag: Springer Berlin Heidelberg
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In this paper, we present a new genetic algorithm for protein structure prediction problem using face-centred cubic lattice and hydrophobic-polar energy model. Our algorithm uses
i
) an exhaustive generation approach to diversify the search;
ii
) a novel hydrophobic core-directed macro move to intensify the search; and
iii
) a random-walk strategy to recover from stagnation. On a set of standard benchmark proteins, our algorithm significantly outperforms the state-of-the-art algorithms for the same models.