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Journal of Nanoparticle Research
Erschienen in: Journal of Nanoparticle Research 5/2013

01.05.2013 | Research Paper

A Promising Combo Gene Delivery System Developed from (3-Aminopropyl)triethoxysilane-Modified Iron Oxide Nanoparticles and Cationic Polymers

verfasst von: Zubin Zhang, Lina Song, Jinlai Dong, Dawei Guo, Xiaolin Du, Biyin Cao, Yu Zhang, Ning Gu, Xinliang Mao

Erschienen in: Journal of Nanoparticle Research | Ausgabe 5/2013

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Abstract

(3-Aminopropyl)triethoxysilane-modified iron oxide nanoparticles (APTES-IONPs) have been evaluated for various biomedical applications, including medical imaging and drug delivery. Cationic polymers (CPs) such as Lipofectamine and TurboFect are widely used for research in gene delivery, but their toxicity and low in vivo efficiency limited their further application. In the present study, we synthesized water-soluble APTES-IONPs and developed a combo gene delivery system based on APTES-IONPs and CPs. This system significantly increased gene-binding capacity, protected genes from degradation, and improved gene transfection efficiency for DNA and siRNA in both adherent and suspension cells. Because of its great biocompatibility, high gene-carrying ability, and very low cytotoxicity, this combo gene delivery system will be expected for a wide application, and it might provide a new method for gene therapy.
Vorheriger Artikel A new function of graphene oxide emerges: inactivating phytopathogenic bacterium Xanthomonas oryzae pv. Oryzae
Nächster Artikel Red shift in absorption edge of Cd1−x Ni x S dilute magnetic semiconductor nanofilms

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Metadaten
Titel
A Promising Combo Gene Delivery System Developed from (3-Aminopropyl)triethoxysilane-Modified Iron Oxide Nanoparticles and Cationic Polymers
verfasst von
Zubin Zhang
Lina Song
Jinlai Dong
Dawei Guo
Xiaolin Du
Biyin Cao
Yu Zhang
Ning Gu
Xinliang Mao
Publikationsdatum
01.05.2013
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 5/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-013-1659-5

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