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Erschienen in:

01.03.2011

A simple mass-action model for the eukaryotic heat shock response and its mathematical validation

verfasst von: Ion Petre, Andrzej Mizera, Claire L. Hyder, Annika Meinander, Andrey Mikhailov, Richard I. Morimoto, Lea Sistonen, John E. Eriksson, Ralph-Johan Back

Erschienen in: Natural Computing | Ausgabe 1/2011

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Abstract

The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes.

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Titel: A simple mass-action model for the eukaryotic heat shock response and its mathematical validation
verfasst von: Ion Petre
Andrzej Mizera
Claire L. Hyder
Annika Meinander
Andrey Mikhailov
Richard I. Morimoto
Lea Sistonen
John E. Eriksson
Ralph-Johan Back
Publikationsdatum: 01.03.2011
Verlag: Springer Netherlands
Erschienen in: Natural Computing / Ausgabe 1/2011
Print ISSN: 1567-7818
Elektronische ISSN: 1572-9796
DOI: https://doi.org/10.1007/s11047-010-9216-y

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