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Medical & Biological Engineering & Computing

Erschienen in:

29.03.2017 | Original Article

A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout

verfasst von: Johannes Port, Ziran Tao, Annika Junger, Christoph Joppek, Philipp Tempel, Kim Husemann, Florian Singer, Philipp Latzin, Sophie Yammine, Joachim H. Nagel, Martin Kohlhäufl

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 11/2017

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Abstract

For the assessment of small airway diseases, a noninvasive double-tracer gas single-breath washout (DTG-SBW) with sulfur hexafluoride (SF₆) and helium (He) as tracer components has been proposed. It is assumed that small airway diseases may produce typical ventilation inhomogeneities which can be detected within one single tidal breath, when using two tracer components. Characteristic parameters calculated from a relative molar mass (MM) signal of the airflow during the washout expiration phase are analyzed. The DTG-SBW signal is acquired by subtracting a reconstructed MM signal without tracer gas from the signal measured with an ultrasonic sensor during in- and exhalation of the double-tracer gas for one tidal breath. In this paper, a simple method to determine the reconstructed MM signal is presented. Measurements on subjects with and without obstructive lung diseases including the small airways have shown high reliability and reproducibility of this method.

Vorheriger Artikel Automatic recognition of severity level for diagnosis of diabetic retinopathy using deep visual features

Nächster Artikel Increasing accuracy of pulse transit time measurements by automated elimination of distorted photoplethysmography waves

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Abbas C, Singer F, Yammine S, Casaulta C, Latzin P (2013) Treatment response of airway clearance assessed by single-breath washout in children with cystic fibrosis. J Cyst Fibros 12(6):567–574CrossRefPubMed

Boeck L, Gensmer A, Nyilas S, Stieltjes B, Re TJ, Tamm M, Latzin P, Stolz D (2016) Single-breath washout tests to assess small airway disease in COPD. Chest 150:1091–1100CrossRefPubMed

Burgel PR (2011) The role of small airways in obstructive airway diseases. Eur Respir Rev 20(119):23–33CrossRefPubMed

Contoli M, Kraft M, Hamid Q, Bousquet J, Rabe KF, Fabbri LM, Papi A (2012) Do small airway abnormalities characterize asthma phenotypes? In search of proof. Clin Exp Allergy 42(8):1150–1160CrossRefPubMed

Diong B, Rajagiri A, Goldman M, Nazeran H (2009) The augmented RIC model of the human respiratory system. Med Biol Eng Comput 47(4):395–404CrossRefPubMed

Granstedt F, Folke M, Ekström M, Hök B, Bäcklund Y (2005) Modelling of an electroacoustic gas sensor. Sens Actuators B Chem 104(2):308–311CrossRef

Green K, Buchvald FF, Marthin JK, Hanel B, Gustafsson PM, Nielsen KG (2012) Ventilation inhomogeneity in children with primary ciliary dyskinesia. Thorax 67(1):49–53CrossRefPubMed

Gustafsson PM (2007) Peripheral airway involvement in CF and asthma compared by inert gas washout. Pediatr Pulmonol 42(2):168–176CrossRefPubMed

Gustafsson PM, Ljungberg HK, Kjellman B (2003) Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout. Eur Respir J 21(6):1033–1039CrossRefPubMed

10.

Gustafsson PM, Robinson PD, Lindblad A, Oberli D (2016) Novel methodology to perform sulfur hexafluoride (SF6)-based multiple-breath wash-in and washout in infants using current commercially available equipment. J Appl Physiol 121:1087–1097CrossRefPubMed

11.

Hamid Q (2012) Pathogenesis of small airways in asthma. Respiration 84(1):4–11CrossRefPubMed

12.

Hansen J (2008) Assessing small airways disease. Eur Respir J 32(5):1410 (author reply 1410–1410; author reply 1411)CrossRefPubMed

13.

Husemann K, Berg N, Engel J, Port J, Joppek C, Tao Z, Singer F, Schulz H, Kohlhäufl M (2014) Double tracer gas single-breath washout: reproducibility in healthy subjects and COPD. Eur Respir J 44(5):1210–1222CrossRefPubMed

14.

Husemann K, Haidl P, Kroegel C, Voshaar T, Kohlhäufl M (2012) Lung function diagnostics for the small airways. Pneumologie 66(5):283–289CrossRefPubMed

15.

Kelly VJ, Brown NJ, King GG, Thompson BR (2010) A method to determine in vivo, specific airway compliance, in humans. Med Biol Eng Comput 48(5):489–496CrossRefPubMed

16.

Latzin P, Thamrin C, Kraemer R (2008) Ventilation inhomogeneities assessed by the multibreath washout (MBW) technique. Thorax 63(2):98–99CrossRefPubMed

17.

Lombardi E, Hall GL, Calogero C (2013) Pulmonary function testing in infants and preschool children. In: Eber E, Midulla F (eds) ERS handbook of paediatric respiratory medicine. European Respiratory Society, Lausanne

18.

Nyilas S, Singer F, Kumar N, Yammine S, Meier-Girard D, Koerner-Rettberg C, Casaulta C, Frey U, Latzin P (2016) Physiological phenotyping of pediatric chronic obstructive airway diseases. J Appl Physiol 121:324–332CrossRefPubMed

19.

O’Rourke C, Klyuzhin I, Park JS, Pollack GH (2011) Unexpected water flow through Nafion-tube punctures. Phys Rev E Stat Nonlin Soft Matter Phys 83(5 Pt 2):056,305CrossRef

20.

Robinson PD, Latzin P, Verbanck S, Hall GL, Horsley A, Gappa M, Thamrin C, Arets HGM, Aurora P, Fuchs SI, King GG, Lum S, Macleod K, Paiva M, Pillow JJ, Ranganathan S, Ratjen F, Singer F, Sonnappa S, Stocks J, Subbarao P, Thompson BR, Gustafsson PM (2013) Consensus statement for inert gas washout measurement using multiple- and single- breath tests. Eur Respir J 41(3):507–522CrossRefPubMed

21.

Rohani M, Pollack GH (2013) Flow through horizontal tubes submerged in water in the absence of a pressure gradient: mechanistic considerations. Langmuir 29(22):6556–6561CrossRefPubMed

22.

Shaw RJ, Djukanovic R, Tashkin DP, Millar AB, du Bois RM, Orr PA (2002) The role of small airways in lung disease. Respir Med 96(2):67–80CrossRefPubMed

23.

Shi Y, Aledia AS, Tatavoosian AV, Vijayalakshmi S, Galant SP, George SC (2012) Relating small airways to asthma control by using impulse oscillometry in children. J Allergy Clin Immunol 129(3):671–678CrossRefPubMed

24.

Singer F, Abbas C, Yammine S, Casaulta C, Frey U, Latzin P (2014) Abnormal small airways function in children with mild asthma. Chest 145(3):492–499CrossRefPubMed

25.

Singer F, Houltz B, Latzin P, Robinson P, Gustafsson P (2012) A realistic validation study of a new nitrogen multiple-breath washout system. PLoS ONE 7(4):e36,083CrossRef

26.

Singer F, Kieninger E, Abbas C, Yammine S, Fuchs O, Proietti E, Regamey N, Casaulta C, Frey U, Latzin P (2013) Practicability of nitrogen multiple-breath practicability of nitrogen multiple-breath washout measurements in a pediatric cystic fibrosis outpatient setting. Pediatr Pulmonol 48(8):739–746CrossRefPubMed

27.

Singer F, Stern G, Thamrin C, Abbas C, Casaulta C, Frey U, Latzin P (2013) A new double-tracer gas single-breath washout to assess early cystic fibrosis lung disease. Eur Respir J 41(2):339–345CrossRefPubMed

28.

Singer F, Stern G, Thamrin C, Fuchs O, Riedel T, Gustafsson P, Frey U, Latzin P (2011) Tidal volume single breath washout of two tracer gases—a practical and promising lung function test. PLoS ONE 6(3):e17,588CrossRef

29.

Tøien Ø (2013) Automated open flow respirometry in continuous and long-term measurements: design and principles. J Appl Physiol 114(8):1094–1107CrossRefPubMed

30.

Tulic MK, Christodoulopoulos P, Hamid Q (2001) Small airway inflammation in asthma. Respir Res 2(6):333–339CrossRefPubMedPubMedCentral

31.

Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M (2006) Role of small airways in asthma: investigation using high-resolution computed tomography. J Allergy Clin Immunol 118(5):1019–1025CrossRefPubMed

32.

Usmani OS, Barnes PJ (2012) Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease. Ann Med 44(2):146–156CrossRefPubMed

33.

van den Berge M, ten Hacken NHT, Cohen J, Douma WR, Postma DS (2011) Small airway disease in asthma and COPD: clinical implications. Chest 139(2):412–423CrossRefPubMed

34.

Van Muylem A, Baran D (2000) Overall and peripheral inhomogeneity of ventilation in patients with stable cystic fibrosis. Pediatr Pulmonol 30(1):3–9CrossRefPubMed

35.

Veiga J, Lopes AJ, Jansen JM, Melo PL (2012) Fluctuation analysis of respiratory impedance waveform in asthmatic patients: effect of airway obstruction. Med Biol Eng Comput 50(12):1249–1259CrossRefPubMed

36.

Verbanck S, Paiva M (2015) Dual gas techniques for peripheral airway function: diffusing the issues. Eur Respir J 45(5):1491–1494CrossRefPubMed

37.

Yammine S, Latzin P (2013) Single- and multible-breath washout techniques. In: Eber E, Midulla F (eds) ERS handbook of paediatric respiratory medicine. European Respiratory Society, Lausanne

38.

Yammine S, Nyilas S, Casaulta C, Schibli S, Latzin P, Sokollik C (2016) Function and ventilation of large and small airways in children and adolescents with inflammatory bowel disease. Inflamm Bowel Dis 22:1915–1922CrossRefPubMed

Titel: A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout
verfasst von: Johannes Port
Ziran Tao
Annika Junger
Christoph Joppek
Philipp Tempel
Kim Husemann
Florian Singer
Philipp Latzin
Sophie Yammine
Joachim H. Nagel
Martin Kohlhäufl
Publikationsdatum: 29.03.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Medical & Biological Engineering & Computing / Ausgabe 11/2017
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI: https://doi.org/10.1007/s11517-017-1633-y

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