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Erschienen in: Pattern Analysis and Applications 1-2/2005

01.09.2005 | Theoretical Advances

A supervised data-driven approach for microarray spot quality classification

verfasst von: Manuele Bicego, Maria Del Rosario Martinez, Vittorio Murino

Erschienen in: Pattern Analysis and Applications | Ausgabe 1-2/2005

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Abstract

In this paper, the problem of classifying the quality of microarray data spots is addressed, using concepts derived from the supervised learning theory. The proposed method, after extracting spots from the microarray image, computes several features, which take into account shape, color and variability. The features are classified using support vector machines, a recent statistical classification technique that is being employed widely. The proposed method does not make any assumptions on the problem and does not require any a priori information. The proposed system has been tested in a real case, for several different parameters’ configurations. Experimental results show the effectiveness of the proposed approach, also in comparison with state-of-the-art methods.

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Fußnoten
1
The B-Course method used by the authors to infer the structure of the Naive Bayesian Networks merely represents a feature selection step.
 
2
The bleeding could be defined as the phenomenon in which a spot spreads so much that it is mixed with its neighbors should be carefully avoided.
 
3
In classification, only the sign is used, not the magnitude.
 
4
Data, together with experiments’ descriptions, data specifications, figures, experts’ classifications and labels are available on the web site http://​sigwww.​cs.​tut.​fi/​TICSP/​SpotQuality/​.
 
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Metadaten
Titel
A supervised data-driven approach for microarray spot quality classification
verfasst von
Manuele Bicego
Maria Del Rosario Martinez
Vittorio Murino
Publikationsdatum
01.09.2005
Erschienen in
Pattern Analysis and Applications / Ausgabe 1-2/2005
Print ISSN: 1433-7541
Elektronische ISSN: 1433-755X
DOI
https://doi.org/10.1007/s10044-005-0254-5

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