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Erschienen in:
2016 | OriginalPaper | Buchkapitel
Animal Models for Translational Cancer Immunotherapy Studies
verfasst von : F. Riccardo, V. Rolih, F. Cavallo
Erschienen in: 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Verlag: Springer Singapore
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The complexity of cancer immunobiology imposes the use of reliable and strongly predictive preclinical animal models to successfully translate immunotherapeutic approaches into the clinical practice. In line with this, increasingly complex and comprehensive experimental mouse models have been developed. As an alternative scenario, comparative oncology proposes the investigation of naturally occurring cancers in pet animals for cancer immunotherapy studies. Veterinary clinical trials are highly predictive of what happens in the human setting, providing excellent translational “avatars” for the study of human cancer and of innovative strategies for its prevention and cure.