Applying object logic programming to design computer strategies in gene scanning

The Cardiovascular Diseases (CVD) have a multifactorial origin. They are caused by mixed effects of some gene and environmental factors. Therefore, gene identification strategies needed to discover involved gene regions are more complex than strategies applied on monogenic diseases. Nowadays, the first ones lack satisfactory levels of performance and efficiency.We present a “in progress” work with the aim to design computational strategies to perform gene screenings to identify new genomic regions associated to atherogenic CVD process. In this work we apply formal methodology and techniques related to logic programming, object-oriented development architectures and combinatorial aspects of genetic model. We have implemented an alpha version of the system which has the main functions designed. And we are actually designing a complete set of data test based on the Framingham Heart Study to compare with classical linkage tools.