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Erschienen in:
2010 | OriginalPaper | Buchkapitel
Atlas-Based Quantification of Myocardial Motion Abnormalities: Added-value for the Understanding of CRT Outcome?
verfasst von : Nicolas Duchateau, Mathieu De Craene, Gemma Piella, Corné Hoogendoorn, Etelvino Silva, Adelina Doltra, Lluís Mont, Ma Angeles Castel, Josep Brugada, Marta Sitges, Alejandro F. Frangi
Erschienen in: Statistical Atlases and Computational Models of the Heart
Verlag: Springer Berlin Heidelberg
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In this paper, we present the use of atlas-based indexes of abnormality for the quantification of cardiac resynchronization therapy (CRT) outcome in terms of motion. We build an atlas of normal motion from 21 healthy volunteers to which we compare 88 CRT candidates before and after the therapy. Abnormal motion is quantified locally in time and space using a statistical distance to normality, and changes induced by the therapy are related with clinical measurements of CRT outcome. Results correlate with recent clinical hypothesis about CRT response, namely that the correction of specific mechanisms responsible for cardiac dyssynchrony conditions the response to the therapy.