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2019 | OriginalPaper | Buchkapitel

Bacteria—Human Interactions: Leads for Personalized Medicine

verfasst von : Željka Maglica, Marina Ožbolt

Erschienen in: Personalized Medicine in Healthcare Systems

Verlag: Springer International Publishing

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Abstract

Bacteria are an integral part of the human body. Together with other microorganisms they form a community in and on the human body known as human microbiome. The microbiome has been found to be crucial for immunologic, hormonal and metabolic homeostasis of its human host. The composition of the microbiome varies considerably among humans and we present the main factors that influence this variability. In addition, the composition of the microbiome has been associated with changes in the central nervous system through the so called “gut-brain axes”. The latest research from this new and exciting field is presented. We then switch our focus from beneficial to pathogenic bacteria. We present the main techniques and methods used to identify pathogenic bacteria and test their sensitivity to antibacterial drugs. Bacteria, like humans, demonstrate individuality in their behavior. This individuality is also present in their drug response, leading to long antibacterial therapy and the possibility of recurrent infections with the same pathogen. Finally, we present data that suggests bacteria are associated with Modic Type 1 changes, pathological changes in the vertebrae. These changes are closely correlated with lower back pain, the most frequent cause of disability for people younger than 45 years of age.

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Vorheriges Kapitel High-Throughput Analytics in the Function of Personalized Medicine

Nächstes Kapitel Present and Future in Personalized Clinical and Laboratory Approaches to In Vitro Fertilization Procedures

Integrative HMP (iHMP) Research Network Consortium (2014).

Kinross et al. (2008).

Nicholson et al. (2005) and Wilson and Nicholson (2009).

Shreiner et al. (2015).

Huttenhower et al. (2012).

Huttenhower et al. (2012) and Turpin et al. (2016).

Benson et al. (2010) and ElRakaiby et al. (2014).

Claesson et al. (2011).

Pflughoeft and Versalovic (2012), Shreiner et al. (2015) and Zoetendal et al. (2008).

Claesson et al. (2011) and Claesson et al. (2016).

Benson et al. (2010), Claesson et al. (2016), ElRakaiby et al. (2014) and Lloyd-Price et al. (2016).

Benson et al. (2010) and ElRakaiby et al. (2014).

Lloyd-Price et al. (2016).

Dinan and Cryan (2017).

Clarke et al. (2013).

Foster and McVey Neufeld (2013).

Carabottia et al. (2015).

Jiang et al. (2015).

Kelly et al. (2016) and Zheng et al. (2016).

Perry et al. (2016).

Dinan and Cryan (2017).

Cryan and O’Mahony (2011).

Dinan and Cryan (2017) and Carabottia et al. (2015).

Tille (2013).

Caliendo (2011) and Kothari et al. (2014).

de Matos et al. (2010).

Balouiri et al. (2016).

Fluit et al. (2001).

Ackermann (2015).

Dhar and McKinney (2007).

Davis and Isberg (2016).

Bhaskar et al. (2014), Bhat et al. (2016), Locke and Elowitz (2009), Locke et al. (2011), Mekterovic et al. (2014), Santi et al. (2013) and Wakamoto et al. (2013).

Maglica et al. (2015).

Bhaskar et al. (2014), Bhat et al. (2016), Mouton et al. (2016).

Lewis (2013).

Albert et al. (2013a, b).

Albert et al. (2013a) and Manniche and Jordan (2016).

Albert et al. (2013b) and Rollason et al. (2013).

Rollason et al. (2013).

Albert et al. (2013a, b).

Ackermann M (2015) A functional perspective on phenotypic heterogeneity in microorganisms. Nat Rev Microbiol 13:497–508CrossRef

Albert HB, Sorensen JS, Christensen BS, Manniche C (2013a) Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy. Eur Spine J 22:697–707CrossRef

Albert HB, Lambert P, Rollason J, Sorensen JS, Worthington T, Pedersen MB, Nørgaard HS, Vernallis A, Busch F, Manniche C et al (2013b) Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae? Eur Spine J 22:690–696CrossRef

Balouiri M, Sadiki M, Ibnsouda SK (2016) Methods for in vitro evaluating antimicrobial activity: a review. J Pharm Anal 6:71–79CrossRef

Benson AK, Kelly SA, Legge R, Ma F, Low SJ, Kim J, Zhang M, Oh PL, Nehrenberg D, Hua K et al (2010) Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci 107:18933–18938CrossRef

Bhaskar A, Chawla M, Mehta M, Parikh P, Chandra P, Bhave D, Kumar D, Carroll KS, Singh A (2014) Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection. PLoS Pathog 10:e1003902CrossRef

Bhat SA, Iqbal IK, Kumar A (2016) Imaging the NADH:NAD(+) homeostasis for understanding the metabolic response of mycobacterium to physiologically relevant stresses. Front Cell Infect Microbiol 6:145CrossRef

Caliendo AM (2011) Multiplex PCR and emerging technologies for the detection of respiratory pathogens. Clin Infect Dis 52:S326–S330CrossRef

Carabottia M, Sciroccoa A, Masellib MA, Severia C (2015) The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 28:1–7

Claesson MJ, Cusack S, O’Sullivan O, Greene-Diniz R, de Weerd H, Flannery E, Marchesi JR, Falush D, Dinan T, Fitzgerald G et al (2011) Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci 108:4586–4591CrossRef

Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, Harris HMB, Coakley M, Lakshminarayanan B, O’Sullivan O et al (2016) Gut microbiota composition correlates with diet and health in the elderly. Nature 488:178–184CrossRef

Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, Dinan TG, Cryan JF (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18:666–673CrossRef

Cryan JF, O’Mahony SM (2011) The microbiome-gut-brain axis: from bowel to behavior: from bowel to behavior. Neurogastroenterol Motil 23:187–192CrossRef

Davis KM, Isberg RR (2016) Defining heterogeneity within bacterial populations via single cell approaches. BioEssays 38:782–790CrossRef

de Matos LL, Trufelli DC, de Matos MGL, da Silva Pinhal MA (2010) Immunohistochemistry as an important tool in biomarkers detection and clinical practice. Biomark Insights 5:9–20CrossRef

Dhar N, McKinney JD (2007) Microbial phenotypic heterogeneity and antibiotic tolerance. Curr Opin Microbiol 10:30–38CrossRef

Dinan TG, Cryan JF (2017) Gut-brain axis in 2016: brain-gut-microbiota axis - mood, metabolism and behaviour. Nat Rev Gastroenterol Hepatol 14(2):69–70CrossRef

ElRakaiby M, Dutilh BE, Rizkallah MR, Boleij A, Cole JN, Aziz RK (2014) Pharmacomicrobiomics: the impact of human microbiome variations on systems pharmacology and personalized therapeutics. OMICS J Integr Biol 18:402–414CrossRef

Fluit AC, Visser MR, Schmitz F-J (2001) Molecular detection of antimicrobial resistance. Clin Microbiol Rev 14:836–871CrossRef

Foster JA, McVey Neufeld K-A (2013) Gut–brain axis: how the microbiome influences anxiety and depression. Trends Neurosci 36:305–312CrossRef

Huttenhower C, Gevers D, Knight R, Abubucker S, Badger JH, Chinwalla AT, Creasy HH, Earl AM, FitzGerald MG, Fulton RS et al (2012) Structure, function and diversity of the healthy human microbiome. Nature 486:207–214CrossRef

Integrative HMP (iHMP) Research Network Consortium (2014) The integrative human microbiome project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease. Cell Host Microbe 16:276–289CrossRef

Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, Wang W, Tang W, Tan Z, Shi J et al (2015) Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun 48:186–194CrossRef

Kelly JR, Borre Y, O’ Brien C, Patterson E, El Aidy S, Deane J, Kennedy PJ, Beers S, Scott K, Moloney G et al (2016) Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res 82:109–118CrossRef

Kinross JM, von Roon AC, Holmes E, Darzi A, Nicholson JK (2008) The human gut microbiome: implications for future health care. Curr Gastroenterol Rep 10:396–403CrossRef

Kothari A, Morgan M, Haake DA (2014) Emerging technologies for rapid identification of bloodstream pathogens. Clin Infect Dis 59:272–278CrossRef

Lewis K (2013) Platforms for antibiotic discovery. Nat Rev Drug Discov 12:371–387CrossRef

Lloyd-Price J, Abu-Ali G, Huttenhower C (2016) The healthy human microbiome. Genome Med 8

Locke JC, Elowitz MB (2009) Using movies to analyse gene circuit dynamics in single cells. Nat Rev Microbiol 7:383–392CrossRef

Locke JC, Young JW, Fontes M, Hernandez Jimenez MJ, Elowitz MB (2011) Stochastic pulse regulation in bacterial stress response. Science 334:366–369CrossRef

Maglica Ž, Özdemir E, McKinney JD (2015) Single-cell tracking reveals antibiotic-induced changes in mycobacterial energy metabolism. MBio 6:e02236–e02214CrossRef

Manniche C, Jordan A (2016) 10 years of research: from ignoring Modic changes to considerations regarding treatment and prevention of low-grade disc infections. Future Sci OA 2

Mekterovic I, Mekterovic D, Maglica Z (2014) BactImAS: a platform for processing and analysis of bacterial time-lapse microscopy movies. BMC Bioinforma 15:251CrossRef

Mouton JM, Helaine S, Holden DW, Sampson SL (2016) Elucidating population-wide mycobacterial replication dynamics at the single-cell level. Microbiol Read Engl 162:966–978CrossRef

Nicholson JK, Holmes E, Wilson ID (2005) Opinion: gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol 3:431–438CrossRef

Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI (2016) Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature 534:213–217CrossRef

Pflughoeft KJ, Versalovic J (2012) Human microbiome in health and disease. Annu Rev Pathol Mech Dis 7:99–122CrossRef

Rollason J, McDowell A, Albert HB, Barnard E, Worthington T, Hilton AC, Vernallis A, Patrick S, Elliott T, Lambert P (2013) Genotypic and antimicrobial characterisation of Propionibacterium acnes isolates from surgically excised lumbar disc herniations. Biomed Res Int 2013:1–7CrossRef

Santi I, Dhar N, Bousbaine D, Wakamoto Y, McKinney JD (2013) Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria. Nat Commun 4:2470CrossRef

Shreiner AB, Kao JY, Young VB (2015) The gut microbiome in health and in disease. Curr Opin Gastroenterol 31:69–75CrossRef

Tille P (2013) Bailey & Scott’s diagnostic microbiology, 13th edn. Mosby, St. Louis

Turpin W, Espin-Garcia O, Xu W, Silverberg MS, Kevans D, Smith MI, Guttman DS, Griffiths A, Panaccione R, Otley A et al (2016) Association of host genome with intestinal microbial composition in a large healthy cohort. Nat Genet 48:1413–1417CrossRef

Wakamoto Y, Dhar N, Chait R, Schneider K, Signorino-Gelo F, Leibler S, McKinney JD (2013) Dynamic persistence of antibiotic-stressed mycobacteria. Science 339:91–95CrossRef

Wilson ID, Nicholson JK (2009) The role of gut microbiota in drug response. Curr Pharm Des 15:1519–1523CrossRef

Zheng P, Zeng B, Zhou C, Liu M, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X et al (2016) Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Mol Psychiatry 21:786–796CrossRef

Zoetendal EG, Rajilic-Stojanovic M, de Vos WM (2008) High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut 57:1605–1615CrossRef

Titel: Bacteria—Human Interactions: Leads for Personalized Medicine
verfasst von: Željka Maglica
Marina Ožbolt
Verlag: Springer International Publishing
Buch: Personalized Medicine in Healthcare Systems
Print ISBN: 978-3-030-16464-5

Electronic ISBN: 978-3-030-16465-2

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-3-030-16465-2_7

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