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Erschienen in:

01.07.2013 | Review

Biodegradable nanoparticles for gene therapy technology

verfasst von: Hossein Hosseinkhani, Wen-Jie He, Chiao-Hsi Chiang, Po-Da Hong, Dah-Shyong Yu, Abraham J. Domb, Keng-Liang Ou

Erschienen in: Journal of Nanoparticle Research | Ausgabe 7/2013

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Abstract

Rapid propagations in materials technology together with biology have initiated great hopes in the possibility of treating many diseases by gene therapy technology. Viral and non-viral gene carriers are currently applied for gene delivery. Non-viral technology is safe and effective for the delivery of genetic materials to cells and tissues. Non-viral systems are based on plasmid expression containing a gene encoding a therapeutic protein and synthetic biodegradable nanoparticles as a safe carrier of gene. Biodegradable nanoparticles have shown great interest in drug and gene delivery systems as they are easy to be synthesized and have no side effect in cells and tissues. This review provides a critical view of applications of biodegradable nanoparticles on gene therapy technology to enhance the localization of in vitro and in vivo and improve the function of administered genes.

Nächster Artikel Filtration behavior of silver nanoparticle agglomerates and effects of the agglomerate model in data analysis

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Titel: Biodegradable nanoparticles for gene therapy technology
verfasst von: Hossein Hosseinkhani
Wen-Jie He
Chiao-Hsi Chiang
Po-Da Hong
Dah-Shyong Yu
Abraham J. Domb
Keng-Liang Ou
Publikationsdatum: 01.07.2013
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 7/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-013-1794-z

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