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Erschienen in:

2017 | OriginalPaper | Buchkapitel

6. Biomedical Features

verfasst von : Mariela A. Agotegaray, Verónica L. Lassalle

Erschienen in: Silica-coated Magnetic Nanoparticles

Verlag: Springer International Publishing

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Abstract

The study of biodistribution and pharmacokinetics of nanosystems devoted to biomedical applications is mandatory, especially for nanodevices with potential applications as agents for targeted drug delivery. The physicochemical properties of silica coated magnetic nanoparticles such as composition, size, and surface charge play important roles in the biological impact of the nanosystems. The biodistribution pattern of the nanoparticles gives information about those organs which are feasible for target and also provides information to develop new strategies to improve targeting. Pharmacokinetics and metabolism are two important issues in terms of the behavior of the magnetic nanoparticles in the organism to ensure a good combination between nanoparticles and specific drugs to treat the desired pathologies.

This chapter reviews the biodistribution, pharmacokinetics, and metabolism of silica, iron oxide nanoparticles, and silica-coated magnetic nanoparticles in order to understand the role of each component in the biological features proposed.

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Titel: Biomedical Features
verfasst von: Mariela A. Agotegaray
Verónica L. Lassalle
Verlag: Springer International Publishing
Buch: Silica-coated Magnetic Nanoparticles
Print ISBN: 978-3-319-50157-4

Electronic ISBN: 978-3-319-50158-1

Copyright-Jahr: 2017
DOI: https://doi.org/10.1007/978-3-319-50158-1_6

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