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Erschienen in:

2017 | OriginalPaper | Buchkapitel

7. Toxicological Insights

verfasst von : Mariela A. Agotegaray, Verónica L. Lassalle

Erschienen in: Silica-coated Magnetic Nanoparticles

Verlag: Springer International Publishing

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Abstract

Many factors govern the toxicological feature of silica-coated magnetic nanoparticles and they are associated with intrinsic features of the nanoparticles and also cell type. In vitro studies on cells and in vivo experiments trend to reveal the biocompatibility of silica and magnetite in the nano-scale.

The knowledge about toxicology of magnetic silica nanoparticles is intended not only to ensure safety of new devices intended for biomedical purposes such as drug targeting and delivery, but also as a tool for therapeutic insights if nanoparticles are present in selective toxicity. Thus, it is important to evaluate toxicological features associated with each novel nanodevice. This chapter describes the mechanisms associated with the toxicology of nano-silica, iron oxide magnetic nanoparticles, and the effects of the combination of the magnetic core with silica in different types of cells as well as the impact in vivo in different animals. All the aspects that govern toxicity are carefully considered and described to provide a global knowledge about the effect on the whole organism.

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Vorheriges Kapitel Biomedical Features

Nächstes Kapitel Future Perspectives on Silica-Coated Magnetic Nanoparticles in Biomedicine

Castranova, V., & Vallyathan, V. (2000). Silicosis and coal workers’ pneumoconiosis. Environmental Health Perspectives, 108(Suppl 4), 675.CrossRef

Saffiotti, U. (1991). Lung cancer induction by crystalline silica. Progress in Clinical and Biological Research, 374, 51–69.

Chen, M., & von Mikecz, A. (2005). Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO₂ nanoparticles. Experimental Cell Research, 305(1), 51–62.CrossRef

Champoux, J. J. (2001). DNA topoisomerases: Structure, function, and mechanism. Annual Review of Biochemistry, 70(1), 369–413.CrossRef

Lin, W., Huang, Y. W., Zhou, X. D., & Ma, Y. (2006). In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicology and Applied Pharmacology, 217(3), 252–259.CrossRef

Abuhijleh, A. L., & Khalaf, J. (2010). Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase–mimetic activities. European Journal of Medicinal Chemistry, 45(9), 3811–3817.CrossRef

Chang, J. S., Chang, K. L. B., Hwang, D. F., & Kong, Z. L. (2007). In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environmental Science & Technology, 41(6), 2064–2068.CrossRef

Park, E. J., & Park, K. (2009). Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicology Letters, 184(1), 18–25.CrossRef

Nishimori, H., Kondoh, M., Isoda, K., Tsunoda, S. I., Tsutsumi, Y., & Yagi, K. (2009). Silica nanoparticles as hepatotoxicants. European Journal of Pharmaceutics and Biopharmaceutics, 72(3), 496–501.CrossRef

10.

Xie, G., Sun, J., Zhong, G., Shi, L., & Zhang, D. (2010). Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Archives of Toxicology, 84(3), 183–190.CrossRef

11.

Yu, T., Malugin, A., & Ghandehari, H. (2011). Impact of silica nanoparticle design on cellular toxicity and hemolytic activity. ACS Nano, 5(7), 5717–5728.CrossRef

12.

Yu, T., Greish, K., McGill, L. D., Ray, A., & Ghandehari, H. (2012). Influence of geometry, porosity, and surface characteristics of silica nanoparticles on acute toxicity: Their vasculature effect and tolerance threshold. ACS Nano, 6(3), 2289–2301.CrossRef

13.

Morris, A. S., Adamcakova-Dodd, A., Lehman, S. E., Wongrakpanich, A., Thorne, P. S., Larsen, S. C., et al. (2016). Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs. Toxicology Letters, 241, 207–215.CrossRef

14.

Hall, J. E. (2015). Guyton and Hall textbook of medical physiology. Philadelphia, PA: Elsevier Health Sciences.

15.

Anzai, Y., Piccoli, C. W., Outwater, E. K., Stanford, W., Bluemke, D. A., Nurenberg, P., et al. (2003). Evaluation of neck and body metastases to nodes with ferumoxtran 10-enhanced MR imaging: Phase III safety and efficacy study 1. Radiology, 228(3), 777–788.CrossRef

16.

Boyer, C., Whittaker, M. R., Bulmus, V., Liu, J., & Davis, T. P. (2010). The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications. NPG Asia Materials, 2(1), 23–30.CrossRef

17.

Solanki, A., Kim, J. D., & Lee, K. B. (2008). Nanotechnology for regenerative medicine: Nanomaterials for stem cell imaging. Nanomedicine, 3(4), 567–578.CrossRef

18.

Markides, H., Rotherham, M., & El Haj, A. J. (2012). Biocompatibility and toxicity of magnetic nanoparticles in regenerative medicine. Journal of Nanomaterials, 2012, 13.CrossRef

19.

Moore, A., Marecos, E., Bogdanov, A., Jr., & Weissleder, R. (2000). Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model 1. Radiology, 214(2), 568–574.CrossRef

20.

Mahmoudi, M., Hofmann, H., Rothen-Rutishauser, B., & Petri-Fink, A. (2011). Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles. Chemical Reviews, 112(4), 2323–2338.CrossRef

21.

Kim, J. S., Yoon, T. J., Yu, K. N., Kim, B. G., Park, S. J., Kim, H. W., et al. (2006). Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicological Sciences, 89(1), 338–347.CrossRef

Titel: Toxicological Insights
verfasst von: Mariela A. Agotegaray
Verónica L. Lassalle
Verlag: Springer International Publishing
Buch: Silica-coated Magnetic Nanoparticles
Print ISBN: 978-3-319-50157-4

Electronic ISBN: 978-3-319-50158-1

Copyright-Jahr: 2017
DOI: https://doi.org/10.1007/978-3-319-50158-1_7

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